[1] 许 刚,何纯青,张 飞,等. 低温3D打印复合万古霉素/PLGA/TCP骨修复材料的制备与性能评估[J].中国美容医学,2021,(5):59-62.
  XU Gang,HE Chun-qing,ZHANG Fei,et al. Preparation and Properties Study on the Low Temperature 3D Printing CompositeVancomycin/PLGA/TCP Scaffold[J].Medical Aesthetics and Beauty,2021,(5):59-62.
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 低温3D打印复合万古霉素/PLGA/TCP骨修复材料的制备与性能评估
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年5期
页码:
59-62
栏目:
出版日期:
2021-05-10

文章信息/Info

Title:
 Preparation and Properties Study on the Low Temperature 3D Printing Composite
Vancomycin/PLGA/TCP Scaffold
文章编号:
1008-6455(2021)05-0059-04
作者:
 许 刚1何纯青1张 飞1克里木1尹东峰2吾木尔1刘 剑1贾 勇1
Author(s):
 XU Gang1HE Chun-qing1ZHANG Fei1KE Li-mu1YIN Dong-feng2WU Mu-er1LIU Jian1JIA Yong1
关键词:
 [关键词]低温3D打印骨缺损修复支架聚乳酸-羟基乙酸磷酸三钙万古霉素
Keywords:
 Key words: low temperature 3D print bone defect repair scaffold poly(lactic-co-glycolic acid)(PLGA) tricalciumphosphate (TCP) vancomycin
分类号:
R622
文献标志码:
A
摘要:
[摘要]目的:采用低温3D打印技术制备复合万古霉素的PLGA/TCP多孔骨缺损修复支架材料,并对其生物相容性和抑菌效果进
行检测,旨在使支架材料促进骨缺损修复的同时,兼具局部抗感染的能力。方法:按15%PLGA+1.5%TCP+1.5%万古霉素的比
例,应用低温快速3D打印技术制备了40%、60%和80%三种不同孔隙率的骨缺损修复支架材料,并对该材料进行表面形态观察
和测量、细胞毒性检测、万古霉素缓释能力实验和抑菌效果检测。结果:扫描电子显微镜观察支架材料见其互连通性好,大
孔直径在550μm左右,孔连通率在90%以上。三种不同孔隙率的支架材料均无细胞毒性,孔隙率为80%的支架材料在万古霉素
缓释能力和抑菌效应方面要显著优于孔隙率为40%和60%的支架材料。结论:应用低温3D打印技术可以直接在生物墨水中加入
注射用万古霉素粉剂,制备出具有良好三维结构的复万古霉素/PLGA/TCP的多孔支架材料,该支架孔通率高,互连通性好,
而且当孔隙率为80%的支架材料在万古霉素缓释能力及抑菌效应方面有着更优的表现,可视为一种具有潜在临床应用价值的
支架材料,尤其适用于感染性骨缺损的修复。

Abstract:
Abstract: Objective To design via low temperature 3D printing composite scaffold (PLGA/TCP) made of poly (lactic-coglycolic
acid) (PLGA) and tricalcium phosphate (TCP) as a basic carrier, incorporating vancomycin powder. The structural
and performance of such composite scaffold is tested, so as to make the scaffolds promote bone defect repair and have antiinfection
ability. Methods According to the ratio of 15%PLGA+1.5%TCP+1.5% vancomycin, such scaffolds were fabricated
using a low-temperature rapid-prototyping 3D printing process,and the porosity for 40%, 60% and 80% were designed. The
surface morphology of the scaffolds were observed and measured, biocompatibility was evaluated by the cytotoxicity test of the
bone marrow mesenchymal cells. The vancomycin release and antibacterial test were also observed in our study. Results The
large pores diameter of the vancomycin incorporated PLGA/TCP scaffold is about 550μm and the pore connectivity is 90%. All
scaffolds have good biocompatibility and no cytotoxicity. The results of vancomycin release and antibacterial test for scaffold
with 80% porosity were significantly superior to those with porosity of 40% and 60%. Conclusion A new type of composite
vancomycin incorporated PLGA/TCP porous scaffold was fabricated using low temperature rapid prototyping technology, and
the scaffold with 80% porosity has better performance in Vancomycin release and antibacterial test, which means that scaffold
can be a scaffold material with potential clinical application value, especially suitable for the repair of infectious bone defect.
更新日期/Last Update: 2021-06-08