[1] 王 薇,范秀红. 5-氨基酮戊酸光动力联合低剂量异维A酸治疗重度痤疮疗效及安全性分析[J].中国美容医学,2021,(10):97-100.
　 WANG Wei,FAN Xiu-hong. Effectiveness and Safety Analysis of 5-Aminoketovaleric Acid Combined withIsotretinoin in the Treatment of Severe Acne[J].Medical Aesthetics and Beauty,2021,(10):97-100.
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 5-氨基酮戊酸光动力联合低剂量异维A酸治疗重度痤疮疗效及安全性分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年10期
页码:
97-100
栏目:
出版日期:
2021-10-10

文章信息/Info

Title:
 Effectiveness and Safety Analysis of 5-Aminoketovaleric Acid Combined with
Isotretinoin in the Treatment of Severe Acne
文章编号:
1008-6455(2021)10-0097-04
作者:
 王 薇; 范秀红
Author(s):
 WANG Wei; FAN Xiu-hong
关键词:
 [关键词] 5-氨基酮戊酸; 异维A酸胶囊; 重度; 寻常痤疮; 安全性
Keywords:
 Key words: 5-aminoketovaleric acid;  isotretinoin capsule;  severe;  acne vulgaris;  safety
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的：观察5-氨基酮戊酸光动力联合低剂量异维A酸胶囊治疗重度痤疮的安全性及疗效。方法：将入选的90例患者按
就诊顺序分为异维A酸组、光动力组及联合组，每组30例。异维A酸组予异维A酸胶囊0.25mg/kg·d，疗程12周；光动力组予
5-氨基酮戊酸光动力治疗，每周1次，共4次；联合组予异维A酸胶囊0.25mg/kg·d，疗程12周，联合光动力4次治疗。比
较三组治疗后4周、12周的有效率及不良反应情况，评判临床疗效及安全性。结果：治疗4周后，光动力组与联合组有效率
均高于异维A酸组（均P ＜0.05）；治疗12周后，联合组有效率高于光动力组及异维A酸组（均P ＜0.05）。治疗过程中，
红斑、疼痛在光动力组及联合组中发生率高于异维A酸组（均P ＜0.05），唇炎在异维A酸组及联合组发生率高于光动力组
（均P ＜0.05），干燥脱屑、血液学、湿疹及色素沉着的发生率三组比较差异均无统计学意义（均P＞0.05）。结论：5-氨基酮戊
酸光动力联合低剂量异维A酸递减疗法治疗重度痤疮疗效确切，起效快、远期疗效佳，且不良反应轻，值得临床应用推广。

Abstract:
Abstract: Objective To observe the safety and effectiveness of 5-aminolevulinic acid photodynamic combined with lowdose
isotretinoin capsules in the treatment of severe acne. Methods The selected 90 patients were divided into isotretinoin
group, photodynamic group and combination group according to the order of treatment, with 30 cases in each group. The
isotretinoin group was given isotretinoin capsules 0.25 mg/kg?d for 12 weeks. The photodynamic group was treated
with 5-aminolevulinic acid photodynamic therapy once a week for a total of 4 times. The combined group was given
Isotretinoin capsules 0.25 mg/kg?d for 12 weeks combined with photodynamic therapy 4 times. The effective rates and
adverse reactions of the 3 groups after 4 weeks and 12 weeks of treatment were compared to evaluate the clinical efficacy and
safety. Results After 4 weeks of treatment, the photodynamic group and the combination group had higher effective rates than
the isotretinoin group (all P ＜0.05). After 12 weeks of treatment, the effective rate of the combined group was higher than that
of the photodynamic group and the isotretinoin group (all P ＜0.05). During of treatment, the incidence of erythema and pain in
the photodynamic and combination groups was higher than that in the isotretinoin group (all P ＜0.05). The incidence of cheilitis
in the isotretinoin group and the combination group was higher than that in the photodynamic group (all P ＜0.05). There was
no statistical difference in the incidence of dry desquamation, hematology, eczema and pigmentation among the three groups
(all P ＞0.05). Conclusion 5-Aminolevulinic acid photodynamic combined with low-dose isotretinoin diminishing therapy is
effective in the treatment of severe acne, with quick onset, good long-term effect and mild adverse reactions, and it is worthy of
clinical application and promotion.

相似文献/References:

[1]刘扬声,郑 蕾,曾 强.异维A酸胶囊联合微针射频等离子治疗中重度痤疮疗效观察[J].中国美容医学,2023,(8):88.[doi:10.15909/j.cnki.cn61-1347/r.005835]
　LIU Yangsheng,ZHENG Lei,ZENG Qiang.Effi cacy of Isotretinoin Capsule Combined with Microneedle Radiofrequency Plasma in the Treatment of Moderate to Severe Acne[J].Medical Aesthetics and Beauty,2023,(10):88.[doi:10.15909/j.cnki.cn61-1347/r.005835]

更新日期/Last Update: 2021-11-03