雄性激素源性脱发治疗方式的研究进展-《中国美容医学》

文章信息/Info

Author(s):: NI Jintao1; YANG Lvjun 1; 2; (1.Department of Burns and Plastic Surgery; 2.Research Center for Translational Medicine,Shantou University Medical College,Shantou 510041,Guangdong,China)

摘要:: 脱发是目前一种常见疾病，一般分为非瘢痕性脱发和瘢痕性脱发。雄性激素源性脱发（Androgenic alopecia,AGA）最为常见，表现为毛囊逐渐微型化后毛发变短、变细软、脱色以及脱落，毛囊纤维化后致永久性脱发，是雄激素依赖的常染色体显性遗传性多变性疾病。目前,治疗方式有局部外用米诺地尔,口服非那雄胺或度那雄胺等,局部注射药物和头发移植等，这些治疗方式的一些作用机制还不是很明确，对于治疗脱发还没有一种标准化的治疗模式。本文主要对治疗雄性激素源性脱发的相关机制、治疗方法，特别是毛发再生技术的应用前景进行综述。

Abstract:: Hair loss is a common disease,generally divided into non-scar alopecia and scar alopecia.Androgenic alopecia (AGA) is the prevalent condition,characterized by miniaturization of the hair follicle with hair getting shorter,thinner,fading,and permanent hair loss due to follicular fibrosis.AGA is an androgen-dependent autosomal dominant polytropic disorder.Currently therapeutic options include topical application of minoxidil, oral administration of finasteride or dutasteride,local injection of hair growth-inducing bioactive components and hair transplantation.The mechanism of some of these treatments is not really clear and there is no generally accepted treatment regime.This article will have a review of the mechanisms,treatment alternatives and especially the prospect of regenerative medicine in AGA treatment