[1]张 淼,周 虹,赵 霞,等.A型肉毒毒素联合类固醇激素与单独类固醇激素治疗病理性瘢痕的系统评价[J].中国美容医学,2023,(1):26-32.
　ZHANG Miao,ZHOU Hong,ZHAO Xia,et al.Botulinum Toxin Type A Combined with Steroids Versus Steroids Alone for the Effects of Pathological Scars: A Systematic Review[J].Medical Aesthetics and Beauty,2023,(1):26-32.
点击复制

A型肉毒毒素联合类固醇激素与单独类固醇激素治疗病理性瘢痕的系统评价()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年1期
页码:
26-32
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Botulinum Toxin Type A Combined with Steroids Versus Steroids Alone for the Effects of Pathological Scars: A Systematic Review
文章编号:
1008-6455（2023）01-0026-06
作者:
张 淼; 周 虹; 赵 霞; 王一枝; 杨璐珊; 郭 杏
(西南医科大学附属医院整形烧伤外科 四川 泸州 646000)
Author(s):
ZHANG Miao; ZHOU Hong; ZHAO Xia; WANG Yizhi; YANG Lushan; GUO Xing
(Department of Plastic and Burn Surgery,Affi liated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)
关键词:
A型肉毒毒素; 类固醇激素; 病理性瘢痕; 瘢痕疙瘩; 目测类比评分; 系统评价; Meta分析
Keywords:
botulinum toxin type A;  steroids;  pathological scars;  keloid;  visual analog scale;  systematic reviews;  Meta-analysis
分类号:
R619+.6
文献标志码:
A
摘要:
目的：采用Meta分析比较A型肉毒毒素联合类固醇激素与单独类固醇激素治疗病理性瘢痕的疗效及安全性。方法：计 算机检索截止2021年3月的Pubmed、EMbase、Cochrane Central Register of controlled Trail、中国知网、万方、维普 以及中国生物医学文献数据库中公开发表的关于A型肉毒毒素联合类固醇激素与单独类固醇激素治疗病理性瘢痕的临床对照 实验。由2名研究员根据纳入及排除标准独立筛选文献、提取资料及质量评价。使用RevMan 5.3和Stata 14.0统计软件，对结局指标进行Meta分析。结果：共纳入11项研究，包括8项随机对照试验，3项病例-队列研究，试验组采用A型肉毒毒素联合类固醇激素局灶内注射，对照组采用类固醇激素局灶内注射，纳入文献总体质量较高。Meta分析结果表明，试验组在目测类比评分［WMD=-2.26，95%CI（-3.07，-1.46），P＜0.00 001］、瘢痕厚度［WMD=-0.94，95%CI（-1.82，-0.06），P=0.04］、满意度评分［WMD=1.51，95%CI（1.21，1.81），P＜0.00 001］、有效率［RR=1.30，95%CI（1.17，1.43），P＜0.00 001］、复发率［RR=0.23，95%CI（0.11，0.49），P=0.0 002］、不良反应发生率［RR=0.65，95%CI（0.42，0.99），P=0.04］等指标均优于对照组，而治疗后两组间瘢痕长度无显著性差异［SMD=-4.30，95%CI（-11.56，2.96），P=0.25］。结论：A型肉毒毒素联合类固醇激素治疗病理性瘢痕的疗效及安全性均优于单独使用类固醇激素。
Abstract:
Objective This paper adopts meta-analysis to compare the eff ectiveness and safety of treating pathological scars with steroids alone and treating that with botulinum toxin type A combined with steroids. Methods The authors have retrieved published articles as of March 2021 of controlled clinical trials regarding treating pathological scars with steroids alone and of treating that with botulinum toxin type A combined with steroids from Pubmed, EMbase, Cochrane Central Register of Controlled Trail, CNKI, Wanfang Data, VIP, and CBMdisc. Based on the inclusion and exclusion criteria, two researchers chose literature, selected resources, and evaluated its qualities. RevMan 5.3 and Stata 14.0 were used to conduct a meta-analysis for the outcomes. Results Eleven research studies were incorporated, including eight randomized controlled trials and three casecohort studies. The experimental group was intralesional injected with botulinum toxin type A combined with steroids; the control group was intralesional injected only with steroids. Overall, the chosen literature has a high quality. The Meta-analysis results showed that the outcome indicators of the experimental group were better than the control group in terms of visual analog scale［WMD=-2.26, 95% CI (-3.07，-1.46), P＜0.00 001］, scar thickness［WMD=-0.94, 95% CI (-1.82，-0.06), P=0.04］, patient satisfaction score［WMD=1.51, 95% CI (1.21，1.81), P＜0.00 001］, efficacy rate［RR=1.30, 95% CI (1.17， 1.43), P＜0.00 001］, relapse rate［RR=0.23,95% CI (0.11, 0.49), P=0.0 002］, rate of adverse drug reactions［RR=0.65, 95% CI (0.42，0.99), P=0.04]. Nevertheless, the scar length of the two groups demonstrated no signifi cant diff erences after the treatment[SMD=-4.30, 95% CI (-11.56，2.96), P=0.25]. Conclusion Both the effectiveness and the safety of treating pathological scars with botulinum toxin type A combined with steroids are better than that with steroids alone

相似文献/References:

[1]肖 洋,陈石海,陈从柏. 连续Y-V成形术联合糖皮质激素及A型肉毒毒素注射治疗瘢痕挛缩畸形[J].中国美容医学,2018,(08):51.
　XIAO Yang,CHEN Shi-hai,CHEN Cong-bo. Application of Continuous Y-V Plasty Combined with Glucocorticoid and Botulinum Toxin Type A in the Treatment of Scar Contracture[J].Medical Aesthetics and Beauty,2018,(1):51.
[2]卢 可,葛红梅,李平松. CO2点阵激光联合A型肉毒毒素透皮给药技术治疗面部痤疮瘢痕临床观察[J].中国美容医学,2018,(08):112.
　LU Ke,GE Hong-mei,LI Ping-song. Clinical Effect and Safety Observation of Fractional Ultra-Pulsed CO2 Laser Combined with Transdermal Delivery of Botulinum Toxin A in the Treatment of Acne Scars[J].Medical Aesthetics and Beauty,2018,(1):112.
[3]姚翠英,陈 芳. 眼周年轻化术后A型肉毒毒素联合透明质酸注射对眼周皱纹改善的效果评价[J].中国美容医学,2019,(02):100.
　YAO Cui-ying,CHEN Fang. Improved Effects Evaluation of Botulinum Toxin Type A Combined with HyaluronicAcid Injection on Periocular Wrinkle after Periocular Rejuvenation Surgery[J].Medical Aesthetics and Beauty,2019,(1):100.
[4]龚卫华,王 楷,周志春. 光纤溶脂联合A型肉毒毒素注射在下面部轮廓整形中的应用[J].中国美容医学,2019,(12):26.
　GONG Wei-hua,WANG Kai,ZHOU Zhi-chun. Application of Faber De-fatting Combined with Botulinum Toxin Type A Injection inthe Cosmetic Treatment of the Lower Contour[J].Medical Aesthetics and Beauty,2019,(1):26.
[5] 尚念胜,牛燕英. A型肉毒毒素对瘢痕疙瘩成纤维细胞TGF-/Smad通路和ERK通路表达的影响[J].中国美容医学,2020,(5):104.
　 SHANG Nian-sheng,NIU Yan-ying. Effects of Botulinum Toxin Type A on the Expression of TGF-β/Smad and ERKPathways in Keloid Fibroblasts[J].Medical Aesthetics and Beauty,2020,(1):104.
[6] 管晓玉 纪 覃 吴 灿 综述,白 南 审校. C02点阵激光治疗皮肤创伤性瘢痕的临床应用及研究进展[J].中国美容医学,2020,(7):169.
　 GUAN Xiao-yu,JI Tan,WU Can,et al. Clinical Application and Research Progress of CO2 Fractional Laser in the Treatmentof Traumatic Skin Scar:A Systematic Review of Literature[J].Medical Aesthetics and Beauty,2020,(1):169.
[7] 王露萍. 点阵CO2激光联合A型肉毒毒素治疗面颈部增生性瘢痕的效果研究[J].中国美容医学,2020,(8):81.
　 WANG Lu-ping. Study on the Cosmetic Effect of Dot Matrix CO2 Laser Combined with Botulinum ToxinType A of Facial and Neck Hypertrophic Scar[J].Medical Aesthetics and Beauty,2020,(1):81.
[8] 张林林,刁永力,徐 建,等. A型肉毒毒素联合氟尿嘧啶注射治疗烧伤瘢痕效果评估[J].中国美容医学,2020,(9):67.
　 ZHANG Lin-lin,DIAO Yong-li,XU Jian,et al. Effects of Botulinum Toxin Type A Combined with Fluorouracil on Burn Scar[J].Medical Aesthetics and Beauty,2020,(1):67.
[9] 高明菊,杨 名,吴炳为,等. A型肉毒毒素联合透明质酸治疗眉间纹效果探讨[J].中国美容医学,2020,(11):51.
　 GAO Ming-ju,YANG Ming,WU Bing-wei,et al. Effect of Botulinum Toxin Type A Combined with Hyaluronic Acid Injection in theTreatment of Glabellar Lines[J].Medical Aesthetics and Beauty,2020,(1):51.
[10] 陈琢琦,亢芷兰,李 巍,等. 电子线联合A型肉毒毒素在胸壁瘢痕疙瘩切除术后的应用效果探讨[J].中国美容医学,2021,(1):28.
　 CHEN Zhuo-qi,KANG Zhi-lan,LI Wei,et al. Application Effect of Electron Beam Irradiation Combined with Botulinum Toxin TypeA after Excision of Keloid on Chest Wall[J].Medical Aesthetics and Beauty,2021,(1):28.

更新日期/Last Update: 2023-01-28