[1]段鳕芸,张忠奎,周 舟,等.强脉冲光联合0.1%他克莫司软膏治疗红斑毛细血管扩张型玫瑰痤疮疗效观察[J].中国美容医学,2023,(1):92-95.
 DUAN Xueyun,ZHANG Zhongkui,ZHOU Zhou,et al.Effect of IPL Combined with 0.1% Tacrolimus Ointment in the Treatment of Erythema Telangiectasia Rosacea[J].Medical Aesthetics and Beauty,2023,(1):92-95.
点击复制

强脉冲光联合0.1%他克莫司软膏治疗红斑毛细血管扩张型玫瑰痤疮疗效观察()
分享到:

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年1期
页码:
92-95
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Effect of IPL Combined with 0.1% Tacrolimus Ointment in the Treatment of Erythema Telangiectasia Rosacea
文章编号:
1008-6455(2023)01-0092-04
作者:
段鳕芸张忠奎周 舟刘太华
(西部战区总医院皮肤科 四川 成都 610083 )
Author(s):
DUAN XueyunZHANG ZhongkuiZHOU ZhouLIU Taihua
(Department of Dermatology,West Theater General Hospital,Chengdu 610083,Sichuan,China)
关键词:
强脉冲光0.1%他克莫司软膏红斑毛细血管扩张型玫瑰痤疮疗效
Keywords:
intense pulsed light 0.1% tacrolimus ointment erythema telangiectasia rosacea effi cacy
分类号:
R758.73+ 4
文献标志码:
A
摘要:
目的:观察强脉冲光(Intense pulsed light,IPL)联合0.1%他克莫司软膏外用治疗玫瑰痤疮的疗效。方法:选择 2019 年2月-2021年2月笔者医院就诊的100例红斑毛细血管扩张型玫瑰痤疮(Erythema telangiectasia rosacea,ETR)患者 为研究对象,采用随机数字表法分为对照组(0.1%他克莫司软膏治疗)50例,观察组(IPL联合0.1%他克莫司软膏治疗) 50 例,比较两组患者治疗效果,记录两组患者治疗前后临床症状改善程度、皮肤红斑指数(Erythema index,EI)、经皮 水分丢失(Transepidermal waterloss,TEWL)、角质层含水量及治疗过程中不良反应发生情况。结果:对照组总有效率 64.00% ,观察组总有效率84.00%,对照组无效5例,观察组仅1例,两组比较差异有统计学意义(P<0.05);治疗后,观察 组红斑、丘疹脓疱、瘙痒、毛细血管扩张评分低于对照组,角质层水含量高于对照组,TEWL、EI低于对照组,差异均有统计 学意义(P<0.05);观察组发生不良反应患者13例(26.00%)、对照组15例(30.00%),治疗后两组均出现短暂红斑和疼 痛,并于2 d内自行消退。结论:0.1%他克莫司软膏联合IPL治疗ETR效果较好,可明显改善面部皮损、促进皮肤屏障功能修 复,无明显不良反应,具有一定的临床应用价值。
Abstract:
Objective To observe the efficacy of IPL combined with 0.1% tacrolimus ointment in the treatment of rosacea. Methods From February 2019 to February 2021,100 patients with ETR were selected as the research objects,50 patients with random digital tables (0.1% Tac Moss Ointment),50 cases of observation group (IPL combined with 0.1% Tam Moss ointment),The treatment eff ects of the two groups were compared; the improvement of clinical symptoms,erythema index (EI),transdermal water loss (TEWL),water content of stratum corneum and the occurrence of adverse reactions were recorded before and after treatment. Results The total eff ective rate was 64.00% in the control group and 84.00% in the observation group.There were 5 invalid patients in the control group and only 1 invalid patient in the observation group.The difference was statistically significant (P <0.05). After treatment,the scores of erythema,papule,pustule,pruritus and telangiectasia in the observation group were lower than those in the control group,the water content in the stratum corneum was higher than that in the control group,and the TEWL and EI in the observation group were lower than those in the control group,the diff erence was statistically signifi cant (P <0.05).There were 13 patients (26.00%) with adverse reactions in the observation group and 15 patients (30.00%) in the control group.After treatment,all patients had transient erythema and pain,which subsided within 2 days. Conclusion 0.1% tacrolimus ointment combined with IPL has good eff ect in the treatment of ETR,which can signifi cantly improve facial skin lesions,promote the repair of skin barrier function,without obvious adverse reactions,and has certain clinical application value.

相似文献/References:

[1]陈劲奕,刘海霞,杨 涛,等. 盐酸米诺环素联合复方甘草酸苷序贯强脉冲光治疗Ⅰ型玫瑰痤疮疗效观察[J].中国美容医学,2018,(04):46.
 CHEN Jin-yi,LIU Hai-xia,YANG Tao,et al. Efficacy of Minocycline Hydrochloride Combined with Compound Glycyrrhizin in Sequential Pulsed Light Therapy for Acne Rosacea[J].Medical Aesthetics and Beauty,2018,(1):46.
[2]石莹莹,陈 炜,王露萍,等. 强脉冲光联合氨甲环酸治疗面部黄褐斑MASI评分观察[J].中国美容医学,2018,(05):36.
 SHI Ying-ying,CHEN Wei,WANG Lu-ping,et al. Observation on MASI Score of Intense Pulsed Light IPL Combined with Oral Transamin in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):36.
[3]黄朝卫,解翠林,石 年,等. 女性黄褐斑的临床特点及点阵激光治疗的效果分析[J].中国美容医学,2018,(06):85.
 HUANG Chao-wei,XIE Cui-lin,SHI Nian,et al.The Clinical Characteristics of Female Chloasma and Cosmetic Effect of Dot Matrix Laser Treatment[J].Medical Aesthetics and Beauty,2018,(1):85.
[4]文丽萍,周书帆,邓 映,等. 短波理疗联合强脉冲光治疗面部糖皮质激素依赖性皮炎临床观察[J].中国美容医学,2018,(11):36.
 WEN Li-ping,ZHOU Shu-fan,DENG Ying,et al. Clinical Observation of Desensitization Apparatus Combined with Intense PulsedLight in the Treatment of Facial Glucocorticosteroid-dependent Dermatitis[J].Medical Aesthetics and Beauty,2018,(1):36.
[5]马慧敏,陈 军,冯仁洋.2013年至2017年1 766例就医者首次光电美容治疗情况分析[J].中国美容医学,2018,(11):43.
 MA Hui-min,CHEN Jun,FENG Ren-yang.Analysis the Aim of 1 766 Visitors of Cosmetic Department from 2013 to 2017[J].Medical Aesthetics and Beauty,2018,(1):43.
[6]陈 燕,李 生,马 明. 强脉冲光联合长脉宽Nd:YAG激光治疗面部毛细血管扩张症疗效观察[J].中国美容医学,2019,(03):54.
 CHEN Yan,LI Sheng,MA Ming. Therapeutic Effect of Intense Pulsed Light Combined with Long Pulse Width Nd:YAGLaser on Facial Telangiectasia[J].Medical Aesthetics and Beauty,2019,(1):54.
[7]刘 冰 齐 婧 综述,李承新 审校. 黄褐斑的光电治疗进展[J].中国美容医学,2019,(05):15.
 LIU Bing,QI Jing,LI Cheng-xin. Progress in Laser and Light Therapy of Melasma[J].Medical Aesthetics and Beauty,2019,(1):15.
[8]刘丽华,杨万军,徐 琪. 超分子水杨酸联合强脉冲光治疗面部痤疮疗效观察[J].中国美容医学,2019,(05):57.
 LIU Li-hua,YANG Wan-jun,XU Qi. Therapeutic Effect of Supramolecular Salicylic Acid Combined with Intense PulseLight in the Treatment of Facial Acne[J].Medical Aesthetics and Beauty,2019,(1):57.
[9]张嘉文 刘子菁 王小燕 Juliandri刘韵祎 马仁燕 综述,许 阳 审校. 玫瑰痤疮的光电治疗研究进展[J].中国美容医学,2019,(05):159.
 ZHANG Jia-wen,LIU Zi-jing,WANG Xiao-yan,et al. Research Progress of Photoelectric for Rosacea[J].Medical Aesthetics and Beauty,2019,(1):159.
[10]邹道佩,蒲以欢,陈阳美,等. 神经酰胺喷剂在强脉冲光嫩肤术后皮肤修复中的疗效观察[J].中国美容医学,2019,(06):40.
 ZOU Dao-pei,PU Yi-huan,CHEN Yang-mei,et al. The Effect of Ceramide Spray on Skin Repair after Intense Pulse Light[J].Medical Aesthetics and Beauty,2019,(1):40.

更新日期/Last Update: 2023-01-30