[1]郭 芳,李颖慧,杨改娥,等.噻吗洛尔联合硫酸羟氯喹治疗红斑毛细血管扩张型玫瑰痤疮的疗效及安全性分析[J].中国美容医学,2023,(2):81-84.
　GUO Fang,LI Yinghui,YANG Gaie,et al.Effi cacy and Safety Analysis of Timolol Combined with Hydroxychloroquine Sulfate in the Treatment of Erythema Telangiectasis Rosacea[J].Medical Aesthetics and Beauty,2023,(2):81-84.
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噻吗洛尔联合硫酸羟氯喹治疗红斑毛细血管扩张型玫瑰痤疮的疗效及安全性分析()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年2期
页码:
81-84
栏目:
出版日期:
2023-02-10

文章信息/Info

Title:
Effi cacy and Safety Analysis of Timolol Combined with Hydroxychloroquine Sulfate in the Treatment of Erythema Telangiectasis Rosacea
文章编号:
1008-6455（2023）02-0081-04
作者:
郭 芳; 李颖慧; 杨改娥; 梁 雁; 牛 洁; 樊娟丽
(运城市中心医院皮肤科 山西 运城 044000 )
Author(s):
GUO Fang; LI Yinghui; YANG Gaie; LIANG Yan; NIU Jie; FAN Juanli
(Department of Dermatology,Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)
关键词:
玫瑰痤疮; 噻吗洛尔; 硫酸羟氯喹; 持久性面部红斑; 疗效; 安全性
Keywords:
rosacea;  timolol;  hydroxychloroquine sulfate;  persistent facial erythema;  effi cacy;  safety
分类号:
R758.73+ 4
文献标志码:
A
摘要:
目的：探讨噻吗洛尔联合硫酸羟氯喹治疗红斑毛细血管扩张型玫瑰痤疮的临床疗效与安全性。方法：选取2018年12 月-2020年12月笔者医院收治的86例红斑毛细血管扩张型玫瑰痤疮患者为研究对象，依照随机数表法分为两组，每组43例。 对照组采用硫酸羟氯喹治疗，观察组在对照组治疗基础上给予噻吗洛尔治疗，两组治疗时间均为8周。对比两组患者丘疹 脓疱数、红斑评分及临床疗效，观察两组血清白细胞介素1α（Interleukin-1α,IL-1α）、白细胞介素8（Interleukin8,IL-8）、肿瘤坏死因子α（Tumor necrosis factor alpha,TNF-α）水平以及不良反应发生情况。结果：治疗后，两组患 者丘疹脓疱数、红斑评分均降低，且观察组更低，差异均有统计学意义（P＜0.05）；治疗后，两组疗效等级分布比较差异 显著（P＜0.05），且观察组的总有效率高于对照组（P＜0.05）；治疗后两组患者血清IL-1α、IL-8、TNF-α水平均降低， 且观察组更低，差异均有统计学意义（P＜0.05）；两组患者不良反应比较，差异无统计学意义（P＞0.05）。结论：采用噻 吗洛尔联合硫酸羟氯喹治疗红斑毛细血管扩张型玫瑰痤疮，能够明显减轻患者面部红斑症状，疗效确切，同时能够降低炎症 反应，安全可靠。
Abstract:
Objective To explore the clinical efficacy and safety of timolol combined with hydroxychloroquine sulfate in the treatment of rosacea-related persistent facial erythema. Methods Eighty-six patients with rosacea-related persistent facial erythema admitted to the hospital from December 2018 to December 2020 were divided into control group and an observation group according to the random number table,with 43 cases in each group.The control group was treated with hydroxychloroquine sulfate,and the observation group was treated with Timolol on the basis of the treatment of the control group,the treatment time of both groups was 8 weeks.The number of pimples,erythema score,clinical effi cacy,and serum levels of interleukin 1α (IL-1α),interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α) and adverse reactions in the two groups were compared. Results After treatment,the number of pimples and pustules and erythema scores in the two groups were decreased (P ＜0.05),and the observation group were lower,the diff erences were statistically signifi cant(P ＜0.05).After treatment,there was a signifi cant diff erence in the distribution of curative eff ects between the two groups (P ＜0.05),and the total eff ective rate of the observation group was higher than that of the control group (P＜0.05).After treatment,the levels of serum IL-1α,IL-8 and TNF-α in the two groups were decreased (P ＜0.05),and the observation group were lower,the diff erences were statistically signifi cant (P ＜0.05).There were no statistically signifi cant diff erence in adverse reactions between the two groups of patients (P ＞0.05). Conclusion Adjuvant treatment of rosacea-related persistent facial erythema with timolol combined with hydroxychloroquine sulfate can alleviate the clinical symptoms,the curative eff ect is defi nite,and at the same time it can reduce the infl ammatory response and it is safe and reliable.

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更新日期/Last Update: 2023-03-07