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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2024年2期

页码:

158-161

栏目:

出版日期:

2024-02-10

文章信息/Info

Title:

Effect of Triple Antibiotic Paste Combined with Pulp Revascularization in Treatment of Pulpitis and Necrotic Permanent Teeth and Its Infl uence on Cytokines in Gingival Crevicular Fluid

文章编号:

1008-6455(2024)02-0158-04

作者:

周姝含¹ ; 周奕含² ; 陈 冲³

(1.苏州口腔医院牙体牙髓科 江苏 苏州 215000 ;2.上海财经大学网络与信息技术中心 上海 200433 ;3.苏州口腔医院口腔 颌面外科 江苏 苏州 215000 )

Author(s):

ZHOU Shuhan¹ ; ZHOU Yihan² ; CHEN Chong³

(1.Department of Dentistry and Endodontics,Suzhou Stomatological Hospital,Suzhou 215000,Jiangsu,China; 2.Network and Information Technology Center,Shanghai University of Finance and Economics,Shanghai 200433,China; 3.Department of Oral and Maxillofacial Surgery,Suzhou Stomatological Hospital,Suzhou 215000,Jiangsu,China)

关键词:

三联抗生素糊剂; 牙髓血运重建术; 牙髓炎; 恒牙坏死; 内皮细胞生长因子; 碱性成纤维细胞生长因子 [

Keywords:

triple antibiotic paste;  dental pulp revascularization;  pulpitis;  permanent necrotic teeth;  vascular endothelial growth factor;  basic fi broblast growth factor

分类号:

R781.3

DOI:

10.15909/j.cnki.cn61-1347/r.006123

文献标志码:

A

摘要:

目的：探究三联抗生素糊剂联合牙髓血运重建术治疗牙髓炎坏死恒牙的疗效以及对龈沟液中血管内皮细胞生长因子 （Vascular endothelial growth factor，VEGF）、碱性成纤维细胞生长因子（Basic fibroblast growth factor，bFGF） 的影响。方法：选取2019年6月-2022年6月笔者医院收治的60例行牙髓血运重建术的牙髓炎坏死恒牙患者，随机分为观察组 和对照组，每组30例。对照组应用氢氧化钙糊剂，观察组应用三联抗生素糊剂。监测两组患者治疗前后的临床疗效，术后1 个月、2个月、3个月的疼痛视觉模拟（Visual analogue scale，VAS）评分，龈沟液中VEGF、bFGF和血小板衍生生长因子 （Platelet-derived growth factor，PDGF）水平。调查两组患者治疗后满意度及不良反应发生情况。结果：治疗后，观察 组总有效率、满意度、VEGF水平、bFGF和PDGF水平均高于对照组（P＜0.05）；患者术后1个月、2个月、3个月VAS评分低于 对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：三联抗生素糊剂联合牙髓血运重建 术治疗牙髓炎坏死恒牙效果良好，可以帮助修复牙髓组织和根尖组织，有效减轻患者疼痛程度，促进牙根发育。

Abstract:

Objective To explore the eff ect of of triple antibiotic paste combined with dental pulp revascularization on permanent necrotic teeth with pulpitis and its eff ect on vascular endothelial growth factor (VEGF) and basic fi broblast growth factor ( bFGF) in gingival crevicular fl uid. Methods A total of 60 patients with permanent necrotic teeth with pulpitis in author’s hospital from June 2019 to June 2022 were selected and randomly divided into study group(n=30) and control group(n=30). The control group received calcium hydroxide combined with dental pulp revascularization, the study group was treated with triple antibiotic paste combined with dental pulp revascularization. Compare the clinical effi cacy, the visual analogue scale (VAS) at the fi rst month, the 2th month and the 3th month after operation, the levels of VEGF, bFGF and platelet derived growth factor (PDGF). The satisfaction and adverse reactions of the two groups were investigated. Results After treatment, the total eff ective rate, the satisfaction, the level of VEGF, the level of bFGF and the level of PDGF were higher, the the VAS score at the fi rst month, at the 2th month and the 3th month of the study group were lower than those of the control group (P ＜0.05). There was no signifi cant diff erence in the incidence of adverse reactions between the two groups(P ＞0.05). Conclusion The triple antibiotic paste combined with dental pulp revascularization in the treatment of permanent necrotic teeth with pulpitis have a good eff ect which can eff ectively reduce the pain of patients, repair pulp and apical tissue and promote root development.

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更新日期/Last Update: 2024-02-27