[1]刘 晶,曾维惠,胡 蝶,等. 他克莫司软膏联合非剥脱1 550nm铒玻璃点阵激光治疗白癜风[J].中国美容医学,2019,(09):12-14.
　LIU Jing,ZENG Wei-hui,HU Die,et al. Combination Therapy of Non-ablative 1 550nm Erbium-glass Lattice Laser and Topical Tacrolimus in the Treatment of Vitiligo[J].Medical Aesthetics and Beauty,2019,(09):12-14.
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 他克莫司软膏联合非剥脱1 550nm铒玻璃点阵激光治疗白癜风
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年09期
页码:
12-14
栏目:
出版日期:
2019-09-05

文章信息/Info

Title:
 Combination Therapy of Non-ablative 1 550nm Erbium-glass Lattice Laser and Topical Tacrolimus in the Treatment of Vitiligo
文章编号:
1008-6455（2019）09-0012-03
作者:
刘 晶1; 曾维惠1; 胡 蝶1; 胡光蕾1; 梁丽丽2; 袁景奕1; 牛新武1
Author(s):
LIU Jing1; ZENG Wei-hui1; HU Die1; HU Guang-lei1; LIANG Li-li2; YUAN Jing-yi1; NIU Xin-wu1
关键词:
[关键词]白癜风; 他克莫司; 铒玻璃; 点阵激光; 联合应用; 临床观察
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：观察非剥脱1 550nm铒玻璃点阵激光联合他克莫司软膏治疗白癜风的疗效及安全性。方法：两组各选取108例患
者，选择皮损部位相近或对称的两处，随机分为对照组和试验组。其中对照组采用外涂他克莫司软膏，试验组采用他克莫司
联合非剥脱1 550nm饵玻璃点阵激光治疗，观察两组患者皮损恢复情况以及治疗过程中出现的不良反应（包括水疱、红斑、
瘙痒和灼热）。结果：疗程结束后对患者临床疗效进行评估，试验组有效率为87.96%，高于对照组的62.96%，差异有统计学
意义（P＜0.05）；试验组患者中，面颈部组有效率高于躯干组及肢端组，差异有统计学意义（P ＜0.05）；两组患者不良反
应（包括水疱、红斑、瘙痒和灼热）发生情况比较，差异无统计学意义。结论：非剥脱1 550nm铒玻璃点阵激光与外用他克
莫司联合，对治疗白癜风具有协同作用，安全性较好，可显著提高白癜风治疗有效率，值得在临床上推广。

Abstract:

(1.Department of Dermatology,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi,China;
2.Department of Dermatology,Shanxi Provincial People’s Hospital,Taiyuan 030012,Shanxi,China)
Abstract: Objective To evaluate the clinical efficacy and safety of tarolimus ointment combined with the non-ablative 1550nm
erbium-glass lattice laser in the treatment of vitiligo. Methods One hundred and eight patients were included every group, two
symmetrical or nearby target lesions of each patients were chosen and were randomly divide into control group and treatment
group. Both groups of lesions were given tacrolimus ointment, in addition to that, the treatment group was given the non-ablative
1 550nm erbium-glass lattice laser. The recovery of skin lesions and adverse reactions (including blisters, erythema, itching and
burning) durinpg treatment were observed in both groups. Results The total effective rate of control group and treatment group
were 62.96% and 87.96%, the difference was statistically significant (P ＜0.05). In the treatment group, the face and neck group are
always more efficient the the trunk, limbs group, the difference was statistically significant (P ＜0.05). There was no statistically
significant difference in the incidence of adverse reactions (including blisters, erythema, itching and burning) between the two
groups. Conclusion The combination therapy of non-ablative 1 550nm erbium-glass lattice laser and topical tacrolimus in the
treatment of vitiligo is safer and better, which improves the effectiveness of vitiligo treatment. It is worthy of clinical promotion.
Key words: vitiligo; tacrolimus; erbium-glass; lattice laser; combined application; clinical observation

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更新日期/Last Update: 2019-09-24