[1] 范向华,施伟伟,黄红娟,等. 低能量Q开关1 064nm激光联合妥塞敏口服治疗黄褐斑疗效观察[J].中国美容医学,2021,(2):29-32.
　 FAN Xiang-hua,SHI Wei-wei,HUANG Hong-juan,et al. Clinical Effect of Low-energy Q-switch 1 064nm Laser Combined with Oral Toxamineon Melasma[J].Medical Aesthetics and Beauty,2021,(2):29-32.
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 低能量Q开关1 064nm激光联合妥塞敏口服治疗黄褐斑疗效观察
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年2期
页码:
29-32
栏目:
出版日期:
2021-02-10

文章信息/Info

Title:
 Clinical Effect of Low-energy Q-switch 1 064nm Laser Combined with Oral Toxamine
on Melasma
文章编号:
1008-6455(2021)02-0029-04
作者:
 范向华; 施伟伟; 黄红娟; 施 健; 花志祥
Author(s):
 FAN Xiang-hua; SHI Wei-wei; HUANG Hong-juan; SHI Jian; HUA Zhi-xiang
关键词:
 [关键词]低能量Q开关1 064nm激光; 妥塞敏; 黄褐斑严重程度指数; 疗效; 黑素指数
Keywords:
 Key words:low-energy Q-switch 1 064nm laser;  toxamine;  melasma severity index;  melasma area;  lesion size
分类号:
R758.4+2
文献标志码:
A
摘要:
[摘要]目的：研究低能量Q开关1 064nm激光联合妥塞敏治疗黄褐斑的疗效。方法：采用随机数字表法将笔者医院2016
年1月-2019年1月收治的90例黄褐斑患者分为A组（低能量Q开关1 064nm激光+妥塞敏，n =30）、B组（低能量Q开关
1 064nm激光，n =30）与C组（单独服用妥塞敏，n =30），三组均连续治疗10周，比较治疗后黄褐斑严重程度指数、皮
损面积及皮损变化。结果：治疗前，三组mMASI评分比较无显著性差异（P ＞0.05），治疗后，三组mMASI得分均较同组
治疗前显著下降（P ＜0.05），且A组治疗后mMASI下降值显著大于B组、C组（P ＜0.05），治疗后，B、C两组mMASI下降值无
显著性差异（P ＞0.05）；三组治疗有效率比较无显著性差异（P ＞0.05）；三组患者治疗各时期皮损部位黑素指数值均显著
高于其正常皮肤（P ＜0.05），治疗后，三组黑素指数均较同组治疗前显著下降（P ＜0.05），治疗前，三组患者皮损黑素指
数无显著性差异（P ＞0.05），但A组治疗5周、10周后，黑素指数均显著低于B组及C组同时间段水平（P ＜0.05），B、C组治
疗后各时间段内皮损黑素指数无显著性差异（P ＞0.05）；三组治疗不良反应发生率比较无显著性差异（P ＞0.05）；随访1
年，三组复发率比较无显著性差异（χ2=2.917，P ＞0.05）。结论：单独应用妥塞敏与低能量Q开关1 064nm激光治疗黄褐斑
疗效相似，但两者联合能有效增强治疗效果，且药物安全性高。

Abstract:

Abstract: Objective To investigate the effect of low-energy Q-switch 1064nm laser combined with toxamine on melasma.
Methods 90 patients with melasma in our hospital from January 2016 to January 2019 were enrolled, and equally divided into
three groups, each with 30 cases. Group A received low-energy Q-switch 1 064nm laser irradiation combined with transamin,
group B received low-energy Q-switch 1 064nm laser irradiation, and group C received transamin only. After 10 weeks of
continuous treatment, the melasma severity index, melasma area and lesion size of the three groups were compared. Results
There was a decrease in modified melasma area and severity index (mMASI) score in all three groups after treatment (P ＜0.05),
and the decrease was more significant in group A than in other two groups (P ＜0.05), while the decrease showed no significant
difference between group B and C (P ＞0.05). The clinical efficacy had no significant difference among three groups (P ＞0.05).
The melanin index of lesion area was higher than that of normal area during treatment in all three groups (P ＜0.05), which
was decreased in all groups after treatment (P ＜0.05). The melanin index had no significant difference among groups before
treatment (P ＞0.05). The melanin index in group A at post-treatment 5w and 10w was lower than that of group B and C (P ＜0.05),
while the melanin index showed no significant difference after treatment (P ＞0.05). The adverse reaction rate had no difference
among three groups (P ＞0.05). The recurrence rate during the post-treatment 1-year follow-up had no significant difference
among three groups (χ2=2.917, P ＞0.05). Conclusion Low-energy Q-switch 1 064nm laser irradiation and transamin show
similar treatment efficacy in the treatment of melasma, while the combination of the two can effectively and safely improve the
treatment effect.

相似文献/References:

[1]刘 晶,朱 瑜,胡 蝶,等.新型1927nm铥激光联合妥塞敏治疗黄褐斑疗效观察[J].中国美容医学,2022,(3):33.
　LIU Jing,ZHU Yu,HU Die,et al.The Clinical Efficacy and Safety of a Novel 1 927 nm Thulium Laser Combined with Transamin in the Treatment of Melasma[J].Medical Aesthetics and Beauty,2022,(2):33.

更新日期/Last Update: 2021-03-09