[1]刘 晶,朱 瑜,胡 蝶,等.新型1927nm铥激光联合妥塞敏治疗黄褐斑疗效观察[J].中国美容医学,2022,(3):33-36.
　LIU Jing,ZHU Yu,HU Die,et al.The Clinical Efficacy and Safety of a Novel 1 927 nm Thulium Laser Combined with Transamin in the Treatment of Melasma[J].Medical Aesthetics and Beauty,2022,(3):33-36.
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新型1927nm铥激光联合妥塞敏治疗黄褐斑疗效观察()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年3期
页码:
33-36
栏目:
出版日期:
2022-03-10

文章信息/Info

Title:
The Clinical Efficacy and Safety of a Novel 1 927 nm Thulium Laser Combined with Transamin in the Treatment of Melasma
文章编号:
1008-6455(2022)03-0033-04
作者:
刘 晶1; 朱 瑜1; 胡 蝶1; 胡光蕾1; 何淑娟1; 焦立鑫2; 苟朋昊3; 曾维惠1
(1.西安交通大学第二附属医院皮肤病院 陕西 西安 710004 ;2.汉中华美奥莱医学整形美容医院皮肤科 陕西 汉中 723000 ;3.旬邑县医院皮肤科 陕西 咸阳 711300 )
Author(s):
LIU Jing1;  ZHU Yu1;  HU Die1;  HU Guanglei1;  HE Shujuan1;  JIAO Lixin2;  GOU Penghao3;  ZENG Weihui1
(1.Department of Dermatology, the Second Affiliated Hospital of Xian Jiaotong University, Xian 710004, Shaanxi, China;2.Department of Dermatology, Hanzhong Huamei Aolai Medical Plastic Surgery Hospital, Hanzhong 723000, Shaanxi, China;3.Department of Dermatology,Xunyi County Hospital, Xianyang 711300, Shaanxi, China)
关键词:
黄褐斑; 1927nm铥激光; 妥塞敏; 非剥脱点阵激光; 联合治疗
Keywords:
melasma; 1 927 nm thulium fiber laser;  transamin;  non-ablative fractional laser;  combination therapy
分类号:
R758.41
文献标志码:
A
摘要:
目的：评估小能量、低密度新型1927nm铥激光联合妥塞敏治疗黄褐斑的临床疗效及安全性。方法：选取30例黄褐斑患者(Fitzpatrick皮肤Ⅲ～Ⅳ型)，随机分为1927nm+妥塞敏组和妥塞敏组。1927nm+妥塞敏组采用新型1927nm铥激光联合妥塞敏治疗，1927nm铥激光治疗重复次数1或2次，治疗间隔4～8周，接受3～5次治疗；妥塞敏口服250毫克/次，早晚各一次，口服3个月；妥塞敏组口服妥塞敏，用法同1927nm+妥塞敏组。由两位研究者评估治疗前、治疗后1个月、3个月和6个月改良的黄褐斑面积及严重程度指数(mMASI)评分、医生整体评价法(Physician global assessment, PGA)、患者自评以及不良反应。结果：与治疗前相比，两组治疗后1个月、3个月及6个月mMASI评分下降，差异有统计学意义（P=0.000）；1927 nm+妥塞敏组治疗后1个月、3个月的mMASI评分下降大于妥塞敏组，差异均有统计学意义（P=0.001，P=0.005）；同时，1927nm+妥塞敏组治疗后1个月、3个月的PGA评分优于妥塞敏组，差异有统计学意义（χ2=5.932，P=0.035；χ2=7.897，P=0.016）；1927nm+妥塞敏组治疗后无明显红斑、水肿、色素沉着以及疼痛等不良反应。结论：新型1927nm铥激光联合妥塞敏治疗黄褐斑安全有效，值得临床推广应用。
Abstract:
Objective To evaluate the clinical efficacy and safety of a novel 1 927 nm thulium laser combined with Transamin in the treatment of Melasma. Methods A total of 30 subjects(Fitzpatrick Ⅲ skin - Ⅳ type) were randomly divided into 1?927?nm+Transamin group and Transamin group.The experimental group was treated with a novel 1?927?nm thulium laser combined with Transamin. The number of 1 927 thulium laser repeats was 1 or 2.Treatment interval was 3 to 5 sessions, and 4 to 8 weeks.Transamin was taken orally 250 mg/time, once in the morning and once in the evening, for 3 months.The control group was given Transamin orally, the same as the experimental group.Modified melasma area and severity index (mMASI) score, Physician Global Assessment(PGA), patient self-assessment, and adverse events were assessed by two investigators before treatment,1, 3,and 6 months after treatment. Results Compared with previous treatment, the mMASI scores in both groups improved to varying degrees 1, 3 and 6 months after treatment, with statistical significance(P=0.000).In the experimental group, mMASI scores descends greater than the control group to varying degrees 1 and 6 months after treatment ,with statistical significance (P=0.001,P=0.001).Meawhile, the PGA scores in 1 and 3 months after treatment were better than the control group, with statistical significance （χ2=5.932,P=0.035,χ2=7.897,P=0.016）.There were no adverse reactions of erythema, edema, chromatism and pain in the treatment group. Conclusion The new 1 927 nm thulium laser combined with Transamin is safe and effective in the treatment of melasma,which is worthy of clinical application.

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更新日期/Last Update: 2022-04-06