[1]李力翠,杨祎峰,毛 伟,等.龙胆草提取物液体敷料治疗面部敏感性皮肤的疗效及对皮肤屏障功能的影响[J].中国美容医学,2023,(11):98-102.[doi:10.15909/j.cnki.cn61-1347/r.006003]
　LI Licui,YANG Yifeng,MAO Wei,et al.Effect of Liquid Dressing Containing Gentian Extract on Patients with Sensitive Skin and Its Effect on the Skin Barrier Function[J].Medical Aesthetics and Beauty,2023,(11):98-102.[doi:10.15909/j.cnki.cn61-1347/r.006003]
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龙胆草提取物液体敷料治疗面部敏感性皮肤的疗效及对皮肤屏障功能的影响()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年11期
页码:
98-102
栏目:
出版日期:
2023-11-10

文章信息/Info

Title:
Effect of Liquid Dressing Containing Gentian Extract on Patients with Sensitive Skin and Its Effect on the Skin Barrier Function
文章编号:
1008-6455（2023）11-0098-05
作者:
李力翠; 杨祎峰; 毛 伟; 王晓茹
(石家庄市藁城人民医院皮肤性病科 河北 石家庄 062160)
Author(s):
LI Licui; YANG Yifeng; MAO Wei; WANG Xiaoru
(Department of Dermatology,Shijiazhuang Gaocheng People’s Hospital,Shijiazhuang 062160,Hebei,China)
关键词:
龙胆草提取物; 液体敷料; 敏感性皮肤; 抗炎因子; 抗敏作用; 皮肤屏障功能
Keywords:
gentian extract;  liquid dressing;  sensitive skin;  anti- infl ammatory factor;  anti-allergic eff ect;  skin barrier function
分类号:
R751
DOI:
10.15909/j.cnki.cn61-1347/r.006003
文献标志码:
A
摘要:
目的：观察含龙胆草提取物液体敷料对敏感性皮肤患者的影响。方法：选择2020年2月-2022年2月于笔者医院治疗 的90例敏感性皮肤患者，按随机数字表法分组，对照组45例，给予饮食及生活指导，采用氯雷他定片、他克莫司软膏控制 临床症状，治疗组45例，在对照组基础上给予含龙胆草提取物液体敷料治疗。治疗前、后检测患者外周血Th1/Th2比例， 检测白细胞介素-10（IL-10）、降钙素基因相关肽（Calcitonin gene related peptide，CGRP）、巨噬细胞炎性蛋白1α （MIP-1α）、白细胞介素-1α（IL-1α）、胸腺基质淋巴细胞生成素（Thymic stromal lymphopoietin，TSLP）水平， 评价患者皮肤损伤情况，记录患者开始刺痛时间、鼻唇沟和面颊刺痛感评分，检测角质层含水量、皮肤pH、经皮水分丢失 （Transepidermal water loss，TEWL）、皮脂含量，给予患者贝克焦虑量表（Beck anxiety inventory，BAI）、皮肤病 生活质量指标调查表（Dermatology life quality index，DLQI），比较两组患者临床疗效。结果：治疗后，治疗 组TSLP、Th1/Th2低于对照组（P＜0.05），治疗组患者MIP-1α、CGRP、IL-1α水平低于对照组（P＜0.05），治疗 组患者IL-10水平高于对照组（P＜0.05），治疗组患者乳酸刺激、皮损评分低于对照组（P＜0.05），治疗组乳酸试 验开始刺痛时间较对照组长（P＜0.05），治疗组TEWL、皮肤pH值较对照组低（P＜0.05），治疗组角质层含水量、皮脂含 量高于对照组（P＜0.05），治疗组BAI、DLQI评分较对照组低（P＜0.05），治疗组患者总有效率（97.50%）较对照组高 （82.50%）（P＜0.05）。结论：含龙胆草提取物液体敷料治疗敏感性皮肤患者，可调节患者免疫，提升抗炎因子水平，抑 制机体炎症，改善患者皮损，提升皮肤抗敏作用及皮肤屏障功能，缓解患者焦虑，提升生活质量及临床疗效。
Abstract:
Objective To observe the eff ect of liquid dressing containing gentian extract on patients with sensitive skin. Methods A total of 90 patients with sensitive skin treated in the author’s hospital from February 2020 to February 2022 were divided into groups according to random number table method, 45 patients in the control group were given diet and life guidance, loratadine tablets and tacrolimus ointment were used to control clinical symptoms, and 45 patients in the treatment group were given liquid dressing containing gentian extract on the basis of the control group. The Th1/Th2 ratio in peripheral blood of patients was detected before and after treatment, and interleukin-10 (IL-10) and Calcitonin gene related peptide were detected. Level of CGRP, macrophage infl ammatory protein 1α (MIP-1α), Interleukin-1α (IL-1α) and Thymic stromal lymphopoietin (TSLP) to evaluate the skin injury of the patients. The time of onset of stabbing, nasolabial groove and cheek tingling were recorded. The cuticle water content, skin pH, Transepidermal water loss (TEWL) and sebum content were detected. The Beck anxiety inventory was administered to the patients. (BAI) and Dermatology life quality index (DLQI) were evaluated to compare the clinical effi cacy of the two groups. Results TSLP and Th1/Th2 in the treatment group were lower than those in the reference group (P＜0.05), the level of MIP-1α, CGRP and IL-1α in the treatment group were significantly lower than those in the reference group (P＜0.05), and the level of IL-10 in the treatment group were signifi cantly lower (P ＜0.05). The scores of lactic acid stimulation and skin lesions in the treatment group were signifi cantly lower than those in the reference group, the time of onset of lactic acid test stinging longer than the reference group(P＜0.05). TEWL and skin pH were lower than those of the reference group (P＜0.05), the stratum corneum water content and sebum content of the treatment group were higher than those of the reference group (P＜0.05), and the BAI and DLQI scores of the treatment group were lower than those of the reference group (P＜0.05). The total eff ective rate (97.50%) in the treatment group was higher than that in the reference group (82.50%) (P＜0.05). Conclusion In the treatment of patients with sensitive skin, liquid dressing containing gentian extract can regulate patients’ immunity, increase the level of anti-infl ammatory factors, inhibit body infl ammation, improve skin lesions, enhance skin anti-sensitivity and skin barrier function, relieve patients’ anxiety, improve quality of life and clinical effi cacy.
更新日期/Last Update: 2023-12-01