[1]陈宇凌,白杨娟,王奕欣,等.女性型脱发患者的血清维生素D水平及与雄激素的相关性研究[J].中国美容医学,2024,(3):100-103.
　CHEN Yuling,BAI Yangjuan,WANG Yixin,et al.Serum Vitamin D Level in Female Pattern Hair Loss Patients and Relationship with Androgen[J].Medical Aesthetics and Beauty,2024,(3):100-103.
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女性型脱发患者的血清维生素D水平及与雄激素的相关性研究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年3期
页码:
100-103
栏目:
出版日期:
2024-03-10

文章信息/Info

Title:
Serum Vitamin D Level in Female Pattern Hair Loss Patients and Relationship with Androgen
文章编号:
1008-6455（2024）03-0100-04
作者:
陈宇凌1 ; 白杨娟2 ; 王奕欣1 ; 董 薪1 ; 李 利1
(四川大学华西医院 1. 皮肤科;2.实验医学科 四川 成都 610041 )
Author(s):
CHEN Yuling1 ; BAI Yangjuan2 ; WANG Yixin1 ; DONG Xin1 ; LI Li1
(1.Department of Dermatology, 2.Department of Experimental Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)
关键词:
女性型脱发; 维生素D; 雄激素; 性激素结合球蛋白; 游离睾酮
Keywords:
female pattern hair loss;  vitamin D;  androgen;  sex hormone binding globulin;  free testosterone
分类号:
R758.71
文献标志码:
A
摘要:
目的：探究女性型脱发的血清维生素D水平以及与雄激素的相关性，为女性型脱发的发病机制及治疗选择提供新的线 索。方法：分析皮肤科门诊就诊的70例女性型脱发患者与体检中心招募的65例健康人的血清维生素D，分析其与严重程度、 人口学特征、生活习惯以及雄激素的相关性。结果：女性型脱发患者的平均维生素D水平（13.59±5.82）ng/ml，健康人群 的平均维生素D水平为（15.94±6.89）ng/ml（P＜0.05）。女性型脱发患者维生素D水平与性激素结合球蛋白呈正相关，与 游离睾酮呈负相关（P＜0.05）。性激素结合球蛋白降低或游离睾酮升高的患者维生素D水平明显降低（P＜0.05）。但暂未 发现女性型脱发患者的维生素D水平与严重程度、人口学特征、生活习惯的相关性。结论：女性型脱发较健康人群维生素D水 平明显降低，提示维生素D降低可能是女性型脱发的发病因素之一。性激素结合球蛋白降低、游离睾酮升高与维生素D水平降 低存在的相关性，可能是维生素D缺乏导致女性型脱发的机制之一，有待进一步研究验证。
Abstract:
Objective To explore the relationship between serum vitamin D levels and androgen levels in female pattern hair loss (FPHL), and to provide new clues for the pathogenesis and treatment of FPHL. Methods We analyzed serum vitamin D levels in 70 patients with female pattern alopecia and 65 healthy subjects recruited from hospital and physical examination center. We also analyzed the relationship between serum vitamin D levels and disease severity, demographic characteristics, lifestyle habits, and androgens. Results The mean levels of serum vitamin D signifi cantly decreased in FPHL, compared to those healthy controls[(13.59±5.82)ng/ml vs (15.94±6.89) ng/ml]. There was a positive correlation between vitamin D and sex hormone binding globulin (SHBG) (P＜0.05), and a negative correlation between vitamin D and free testosterone (P＜0.05). Serum vitamin D levels was signifi cantly lower in those patients with decrease SHBG or elevated free testosterone. However, no correlation was found between vitamin D level and severity, demographic characteristics, and lifestyle in FPHL. Conclusion The vitamin D level of FPHL is signifi cantly lower than that of healthy people, suggesting that the decrease of vitamin D may be one of the pathogenesis factors of FPHL. The correlation between SHBG, free testosterone and vitamin D may be the reason of the vitamin D defi ciency in FPHL, which needs more studies to verify. Serum vitamin D, SHBG and free testosterone should be monitored more actively in FPHL patients.

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[1] 杨芝香,康定华. 窄谱中波紫外线对白癜风患者血清维生素D水平的影响[J].中国美容医学,2020,(6):42.
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更新日期/Last Update: 2024-03-21