[1]吕 君,雷淑英,周发琼,等. 红蓝光联合重组人表皮生长因子凝胶对面部糖皮质激素依赖性皮炎患者皮肤功能改善的影响[J].中国美容医学,2019,(02):53-55.
　LV Jun,LEI Shu-ying,ZHOU Fa-qiong,et al. Effect of LED Red-Blue and Recombinant Human Epidermal Growth Factor Gel onSkin Function Improvement in Patients with Facial Hormone-Dependent Dermatitis[J].Medical Aesthetics and Beauty,2019,(02):53-55.
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 红蓝光联合重组人表皮生长因子凝胶对面部糖皮质激素依赖性皮炎患者
皮肤功能改善的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年02期
页码:
53-55
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
 Effect of LED Red-Blue and Recombinant Human Epidermal Growth Factor Gel on
Skin Function Improvement in Patients with Facial Hormone-Dependent Dermatitis
文章编号:
1008-6455(2019)02-0053-03
作者:
吕 君1; 雷淑英1; 周发琼1; 张 洋1; 段雨函2
Author(s):
LV Jun1; LEI Shu-ying1; ZHOU Fa-qiong1; ZHANG Yang1; DUAN Yu-han2
关键词:
 ; [关键词]面部糖皮质激素依赖性皮炎; 皮肤功能; 免疫功能; 重组人表皮生长因子凝胶; LED红蓝光
Keywords:
Key words: facial hormone-dependent dermatitis;  skin function;  immune function;  recombinant human epidermal growth factorgel;  LED red blue light
分类号:
R758.22
文献标志码:
A
摘要:
[摘要]目的：探讨LED红蓝光联合重组人表皮生长因子(rhEGF)凝胶对面部糖皮质激素依赖性皮炎(FCAD)患者皮肤功能改善
的影响。方法：选取2015年10月-2017年10月在笔者医院接受治疗的96例FCAD患者，根据随机数字表法分成两组。对照组：
48例，采用rhEGF凝胶治疗；观察组：48例，在对照组基础上采用LED红蓝光治疗；观察两组患者疗效、不良反应及复发状
况，检测治疗前后患者经皮水分丢失（TEWL）、表皮油脂含量和表皮含水量，ELISA法检测血清干扰素-γ（IFN-γ）、免
疫球蛋白-E（IgE）及白细胞介素-4（IL-4）含量。结果：观察组治疗总有效率为89.58%，对照组为60.42%，差异有统计
学意义(P ＜0.05)；治疗后两组患者表皮油脂含量、表皮含水量较治疗前显著升高，TEWL较治疗前显著降低，且观察组效果
更优，和对照组比较差异均有统计学意义（P ＜0.05）；治疗后观察组血清IFN-γ、IgE及IL-4含量较治疗前、对照组显著降
低，差异均有统计学意义（P ＜0.05）。结论：LED红蓝光结合rhEGF治疗FCAD疗效显著，可明显改善患者皮肤屏障功能。
Abstract:
Abstract: Objective To analyze the effect of LED red-blue combined with recombinant human epidermal growth factor
(rhEGF) gel on the improvement of skin function in patients with facial hormone-dependent dermatitis (FCAD). Methods
A total of 96 patients with FCAD who were treated in our hospital between October 2015 and October 2017 were randomly
divided into two groups. The control group (48 cases)was treated with rhEGF gel. The observation group (48 cases)was On the
basis of the control group, LED red blue light was used to treat the patients; the efficacy, adverse reactions, and recurrence of
the patients were observed; the transepidermal water loss (TEWL), epidermis oil content, and epidermal water content were
measured before and after treatment; the levels of serum interferon-γ (IFN-γ), immunoglobulin-E (IgE), and interleukin-4 (IL-4)
were measured by ELISA. Results The total effective rate was 89.58% in the observation group and 60.42% in the control group.
The difference was statistically significant (P＜0.05). After treatment, the oil and epidermis water content of the two groups were
significantly higher than before treatment. TEWL was more effective than the treatment. The former was significantly lower,
and the observation group was more effective, and there was a statistically significant difference between the control group and
the control group (P ＜0.05). After treatment, the serum IFN-γ, IgE and IL-4 levels in the observation group were significantly
lower than before treatment and control groups. The difference was statistically significant (P＜0.05). Conclusion LED red-blue
combined with rhEGF has a significant effect on FCAD patients and can significantly improve skin barrier function.

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更新日期/Last Update: 2019-03-07