[1]尹 诗,张 静,罗丽娜,等. 重组人表皮生长因子凝胶联合中药治疗面部糖皮质激素依赖性皮炎疗效分析[J].中国美容医学,2020,(2):95-98.
　YIN Shi,ZHANG Jing,LUO Li-na,et al. Effi cacy of Recombinant Human Epidermal Growth Factor Gel Combined withTraditional Chinese Medicine on Facial Corticosteroid Addictive Dermatitis[J].Medical Aesthetics and Beauty,2020,(2):95-98.
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 重组人表皮生长因子凝胶联合中药治疗面部糖皮质激素依赖性皮炎
疗效分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年2期
页码:
95-98
栏目:
出版日期:
2020-03-15

文章信息/Info

Title:
 Effi cacy of Recombinant Human Epidermal Growth Factor Gel Combined with
Traditional Chinese Medicine on Facial Corticosteroid Addictive Dermatitis
文章编号:
1008-6455（2020）02-0095-04
作者:
 尹 诗1; 张 静2; 罗丽娜2; 韩 俊1
Author(s):
 YIN Shi1;  ZHANG Jing2;  LUO Li-na2;  HAN Jun1
关键词:
 ; [关键词]面部糖皮质激素依赖性皮炎; 重组人表皮生长因子凝胶; 中药; 皮肤功能指标; T淋巴亚群细胞水平
Keywords:
 ; Key words: facial corticosteroid addictive dermatitis; recombinant human epidermal growth factor gel;  traditional chinesemedicine;  the skin function indexes;  T lymphocyte subsets
分类号:
R758.22
文献标志码:
A
摘要:
[摘要]目的：探讨重组人表皮生长因子凝胶联合中药治疗面部糖皮质激素依赖性皮炎(FCAD)的疗效。方法：收集124例FCAD
（热毒蕴结型）患者资料，随机分为对照组和观察组,两组均给予口服复方甘草酸苷片，对照组加用重组人表皮生长因子凝
胶外敷治疗，观察组在对照组用药基础上加服中药（清热解毒方）治疗。观察两组治疗前及治疗4周后的中医症状积分，评
估两组临床疗效，对比两组治疗前及治疗4周的皮肤功能指标和T淋巴亚群细胞水平。结果：治疗4周后，两组患者的红斑、丘
疹、干燥脱屑及痛痒灼热四项中医症状评分均显著降低(P ＜0.05)，观察组下降幅度显著大于对照组(P ＜0.05)；观察组临床
总有效率可达88.71%，显著高于对照组的72.58%(P＜0.05)；治疗4周后，两组患者的表皮油脂含水量、表皮含水量显著提高(P
＜0.05)，经皮水分丢失(TEWL)值显著降低，两组患者的外周血CD4+、CD8+ T淋巴细胞亚群含量和CD4+/CD8+ T淋巴细胞亚群比
值显著降低(P＜0.05)，观察组变化幅度显著大于对照组(P ＜0.05)。结论：重组人表皮生长因子凝胶联合中药治疗FCAD疗效
确切，能明显减轻其红斑、丘疹、干燥脱屑及痛痒灼热等症状，有效促进皮损及早修复和皮肤屏障功能提高。

Abstract:
Abstract: Objective To investigate the effi cacy of recombinant human epidermal growth factor gel combined with traditional
Chinese medicine in the treatment of facial corticosteroid addictive dermatitis (FCAD). Methods The data of 124 cases
of FCAD patients (heat-toxic accumulating type of drug toxicity) were collected, and the patients were randomly divided
into control group and observation group. They were given compound glycyrrhizin tablets, and control group was treated
with external application of recombinant human epidermal growth factor gel, and observation group was additionally given
traditional Chinese medicine (Qingre Jiedu prescription) on the basis of control group. The TCM symptoms scores were
observed in the two groups before treatment and after 4 weeks of treatment. The clinical efficacy in the two groups was
evaluated. The skin function indexes and T lymphocyte subsets were compared between the two groups before treatment
and after 4 weeks of treatment. Results After 4 weeks of treatment, the scores of four items of TCM symptoms of erythema,
papules, dry desquamation and itching and burning were signifi cantly decreased in the two groups (P ＜0.05), and the decreases
in observation group were signifi cantly greater than those in control group (P ＜0.05). The total clinical effective rate was
up to 88.71% in observation group, which was signifi cantly higher than 72.58% in control group (P ＜0.05). After 4 weeks
of treatment, the epidermal grease water content and epidermal water content were significantly increased in the two
groups (P <0.05), and the transepidermal water loss (TEWL) value was signifi cantly decreased, and the CD4+ and CD8+ T
lymphocyte subsets and ratio of CD4+/CD8+ T lymphocyte subsets in peripheral blood in the two groups were signifi cantly
decreased (P ＜0.05), and the changes in observation group were signifi cantly greater than those in control group (P ＜0.05).
Conclusion Recombinant human epidermal growth factor gel combined with traditional Chinese medicine has exact effi cacy in
the treatment of FCAD, and it can signifi cantly reduce the symptoms of erythema, papules, dry desquamation and itching and
burning, and effectively promote the early repair of skin lesions and the improvement of skin barrier function.

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更新日期/Last Update: 2020-03-31