[1]鲁光炜,焉 钰,何武成. 初始力值对远中移动牙龈沟液TIMP-2和PGE2水平的影响[J].中国美容医学,2019,(11):118-120.
　LU Guang-wei,YAN Yu,HE Wu-cheng. Effect of Initial Force Value on TIMP-2 and PGE2 Levels in Distal Moving Gingival Crevicular Fluid[J].Medical Aesthetics and Beauty,2019,(11):118-120.
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 初始力值对远中移动牙龈沟液TIMP-2和PGE2水平的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年11期
页码:
118-120
栏目:
出版日期:
2019-11-05

文章信息/Info

Title:
 Effect of Initial Force Value on TIMP-2 and PGE2 Levels in Distal Moving Gingival Crevicular Fluid
文章编号:
1008-6455(2019)11-0118-03
作者:
 鲁光炜; 焉 钰; 何武成
Author(s):
 LU Guang-wei;  YAN Yu;  HE Wu-cheng
关键词:
 ; [关键词]远中移动初始力; 错牙合畸形; TIMP-2水平; PGE2水平; 正畸治疗
Keywords:
 ; Key words: distal mobile initial force;  malocclusion;  TIMP-2 level;  PGE2 level;  orthodontic treatment
分类号:
R783.5
文献标志码:
A
摘要:
[ 摘要] 目的： 探究不同远中移动初始力对错牙合畸形患者金属蛋白酶组织抑制物（ T i s s u e i n h i b i t o r o f
metalloproteinase，TIMP-2）、前列腺素E2（Prostaglandin E2，PGE2）水平的影响。方法：选取2015年4月-2018年3月笔
者医院收治的114例错牙合畸形患者为研究对象，按照随机数字法分为A、B、C三组，每组38例，所有患者均接受正畸治疗，
各组给予患者50g、100g、200g的远中移动初始力，分别对两侧上颌尖牙于加力前、加力后1、2、3、4周检测TIMP-2，1周内
检测PGE2水平并记录。结果：治疗1、2、3、4周后，B组龈沟液TIMP-2水平明显高于A、C组（P ＜0.05）；龈沟液PGE2
水平在24h、48h明显升高，在168h后逐渐回到基线水平；B组治疗1h、24h、48h、72h龈沟液PGE2水平明显高于A、C组
（P ＜0.05）。 结论：错牙合畸形患者龈沟液中TIMP-2、PGE2水平与不同远中移动初始力及持续时间相关，100g作用力下是
最佳矫治力，同时TIMP-2、PGE2水平可作为远中移动初始力重要参考指标。

Abstract:
Abstract: Objective To investigate the effects of different distal mobileinitial forces on t TIMP-2 and PGE2 levels in patients
with malocclusion. Methods A total of 114 patients with malocclusion admitted in our hospital between April 2015 and March
2018 were divided into the group A, group B and group C according to the random number method with 38 cases in each
group. All patients received orthodontic treatment and were given initial force of 50g, 100g and 200g in the distal movement,
repectively. TIMP-2 was detected on both sides of the maxillary canine before stress and 1, 2, 3 and 4 weeks after the stress.
PGE2 levels were measured and recorded within one week. Results The level of TIMP-2 in the gingival crevicular fluid (GCF)
of group B was significantly higher than that of group A and group C 1, 2, 3 and 4 weeks after treatment (P ＜0.05).The level of
PGE2 in GCF was significantly increased at 24h and 48h and gradually decreased to baseline after 168h; PGE2 levels in GCF
were significantly higher in the group B than in the group A and group C at 1h, 24h, 48h and 72h (P ＜0.05). Conclusion The
levels of TIMP-2 and PGE2 in GCF of patients with malocclusion are related to the different distal mobile initial force and
duration,the best under 100g force. Meanwhile, the TIMP-2 and PGE2 levels can be used as the important reference indexes
fordistal mobile initial force.

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更新日期/Last Update: 2019-12-10