[1]张 丽,陈振平,杨慈航,等. 中药面膜辅助治疗黄褐斑临床疗效Meta分析及用药规律探讨[J].中国美容医学,2020,(3):106-111.
　ZHANG Li,CHEN Zhen-ping,YANG Ci-hang,et al. Meta-analysis of Therapeutic Effi cacy of TCM Masque for Chloasma AndInvestigation on the Regularity of Prescription Selection and Medicine Use[J].Medical Aesthetics and Beauty,2020,(3):106-111.
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 中药面膜辅助治疗黄褐斑临床疗效Meta分析及用药规律探讨
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年3期
页码:
106-111
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
 Meta-analysis of Therapeutic Effi cacy of TCM Masque for Chloasma And
Investigation on the Regularity of Prescription Selection and Medicine Use
文章编号:
1008-6455(2020)03-0106-06
作者:
 张 丽1; 陈振平1; 杨慈航1; 李婉溶1; 杨志波1
Author(s):
 ZHANG Li1; CHEN Zhen-ping1; YANG Ci-hang1; LI Wan-rong1; YANG Zhi-bo2
关键词:
 ; [关键词]中药面膜; 黄褐斑; 疗效; Meta分析; 用药规律
Keywords:
 ; Key words: herbal mask;  melasma;  therapeutic effi cacy;  meta-analysis;  regularity of medicine use
分类号:
R758.4+2
文献标志码:
A
摘要:
[摘要]目的：系统评价中药面膜辅助治疗黄褐斑的疗效与安全性，探讨中药面膜中的用药规律，为临床诊疗提供参考。方法：
计算机检索中国期刊全文数据库、维普数据库、万方数据库及Pubmed等，收集中药面膜单独或联合常规治疗方法，对比常规
治疗方案治疗黄褐斑的随机对照试验（Randomized controlled trials,RCT）研究，依据Cochrane Reviewer Handbook 5.1中
文献质量评价条例评价后，采用Review Manager Software 5.3统计软件对数据进行荟萃分析，对临床试验中使用的中药进行
频次和药味统计分析。结果：共纳入13项RCT，合计1 036例患者。Meta分析结果显示，试验组患者的总有效率[RR=1.24,95%
CI(1.15,1.33),P ＜0.00001]、两组患者复发率比较[RR=0.23,95% CI(0.10,0.53),P ＜0.001]，结果显示试验组临床有效率
高，复发率低，差异具有统计学意义。试验组与对照组在治疗期间均有部分患者有皮肤泛红不适等轻度不良反应，两组比较
无统计学意义。删除纳入的13项RCT中的重复方剂后，共纳入10首方剂，共包含29味药，药材出现总频次为94次。其中，使
用频次最高的药味主要是白芷、茯苓、当归、红花、白芨、三七、白附子等，以活血、清热类药物使用频率最多，药材性味
以辛、甘、苦三种为主。结论：中药面膜辅助治疗黄褐斑临床疗效明确，复发率低，用药以活血及清热药为主。

Abstract:
Abstract: Objective To systematically evaluate the effi cacy and safety of TCM mask for treatment of chloasma, to investigate
the rules of drugs used in TCM masks. Methods Retrieved from CNKI,VIP, Wanfang Database, Pubmed, etc,randomized
controlled trials (RCT) about clinical effi ciency and adverse drug reactions of chloasma in TCM mask alone or combined with
conventional drugs (test group) vs. conventional treatment (control group) in the treatment of chloasma were included. Metaanalysis
was conducted by using Review Manager Software 5.3 after data extraction of studies were evaluated with Cochrane
Reviewer Handbook 5.1.0.Frequency statistics were conducted among included prescriptions. Results A total of 13 RCTs were
included, totaling 1036 patients. Meta-analysis showed that the clinical effective rate of patients in the experimental group [RR=1.24,
95% CI (1.15, 1.33), P＜0.00001], the recurrence rate of the two groups was compared [RR=0.23, 95% CI(0.10,0.53) , P ＜0.001]
were signifi cantly better than the control group, and the difference was statistically signifi cant. Some adverse drug reactions
happened in the experimental group and the control group during the treating time.There were 10 prescriptions were collected
after the repeated prescriptions were deleted.Above prescriptions were add up by statistical analysis;there were 29 ingredients
in the clinical studies,and the total frequency for these drugs is 94. The most frequently used medicinal ingrediants are Dahurian
angelica, Poria cocos, Angelica sinensis, saffl ower, Bletilla striata, Panax notoginseng, rhizoma typhonii, etc,and the higher
frequency of the ingredients was blood circulation and heat-clearing drugs, and the medicinal properties are symplectic, sweet
and bitter. the Lord. Conclusion The clinical efficacy and recurrence rate of Chinese medicine mask in the treatment of
chloasma is clear.The main drugs are blood circulation and heat-clearing drugs.

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更新日期/Last Update: 2020-04-28