[1] 丁 钰,黄忠奎,胡秀玲. 自身免疫性甲状腺疾病患者血清25-（OH）D表达水平与白癜风的相关性分析[J].中国美容医学,2020,(10):111-114.
　 DING Yu,HUANG Zhong-kui,HU Xiu-ling. Correlation between Serum 25-(OH)D Expression Level and Vitiligo in Patients withAutoimmune Thyroid Disease[J].Medical Aesthetics and Beauty,2020,(10):111-114.
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 自身免疫性甲状腺疾病患者血清25-（OH）D表达水平与白癜风
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年10期
页码:
111-114
栏目:
出版日期:
2020-10-10

文章信息/Info

Title:
 Correlation between Serum 25-(OH)D Expression Level and Vitiligo in Patients with
Autoimmune Thyroid Disease
文章编号:
1008-6455（2020）10-0111-04
作者:
 丁 钰1; 黄忠奎1; 胡秀玲2
Author(s):
 DING Yu1; HUANG Zhong-kui1; HU Xiu-ling2
关键词:
 [关键词]自身免疫性甲状腺疾病; 25-羟维生素D; 表达水平; 白癜风; 临床病理特征; 相关性
Keywords:
 Key words: autoimmune thyroid disease;  25-(OH)D;  expression level;  vitiligo;  clinicopathological features;  correlation
分类号:
R581
文献标志码:
A
摘要:
[摘要]目的：探究自身免疫性甲状腺疾病（AITD）患者血清25羟维生素D[25-(OH)D]表达水平与白癜风的相关性。方法：前
瞻性选择2018年12月-2019年12月笔者医院收治的125例自身免疫性甲状腺疾病患者，其中桥本甲状腺炎（HT）51例为HT组，
Graves病（GD）74例为GD组，同期体检健康者50例为对照组，比较HT组、GD组、对照组血清25-（OH）D水平，根据自身免疫性
甲状腺疾病患者是否合并白癜风分为非白癜风组（n=87）与白癜风组（n=38），比较非白癜风组与白癜风组血清25-（OH）D水
平，采用Spearman相关分析血清25-（OH）D水平与自身免疫性甲状腺疾病伴白癜风的相关性，比较不同临床病理特征的自身
免疫性甲状腺疾病伴白癜风患者血清25-（OH）D水平。结果：HT组、GD组血清25-（OH）D水平显著低于对照组，差异有统
计学意义（P ＜0.05）；GD组血清25-（OH）D水平较HT组比较差异无统计学意义（P ＞0.05）；白癜风组血清25-（OH）D
水平显著低于非白癜风组，差异有统计学意义（P ＜0.05）；血清25-（OH）D水平与自身免疫性甲状腺疾病伴白癜风呈负
相关（P ＜0.05）；不同性别、分型、分期、受累面积的自身免疫性甲状腺疾病伴白癜风患者血清25-（OH）D水平比较差
异无统计学意义（P ＞0.05）；不同年龄、病程的自身免疫性甲状腺疾病伴白癜风患者血清25-（OH）D水平差异具有统计
学意义（P ＜0.05）。结论：自身免疫性甲状腺疾病患者血清25-（OH）D呈低表达，其表达水平与白癜风呈负性相关，血清
25-（OH）D水平检测对自身免疫性甲状腺疾病伴白癜风具有重要临床指导意义。
Abstract:
Abstract: Objective To investigate the correlation between serum 25-hydroxy vitamin D [25-(OH)D] expression level and
vitiligo in patients with autoimmune thyroid disease (AITD). Methods 125 AITD patients in our hospital from December
2018 to December 2019 were enrolled prospectively, including 51 cases of HT patients (HT group) and 74 cases of GD patients
(GD group), meanwhile, another 50 healthy individuals were enrolled as control group. AITD patients were divided into two
subgroups according to the presence or absence of vitiligo, non-vitiligo group (n =87) and vitiligo group (n=38). 25-(OH)D levels
were compared between groups and subgroups. Correlation between 25-(OH)D level and vitiligo was analyzed by spearman
correlation analysis. Then the serum 25-(OH)D levels were compared among AITD combined with vitiligo patients with
different clinicopathological characteristics. Results 25-(OH)D level of HT group and GD group was lower than that of control
group (P ＜0.05), while no difference was found between GD group and control group (P ＞0.05). 25-(OH)D level of vitiligo
group was lower than that of non-vitiligo group (P ＜0.05). Serum 25-(OH)D level was negatively correlated with the incidence
rate of vitiligo in AITD patients (P ＜0.05). Serum 25-(OH)D level of AITD patients with vitiligo had no significant difference
among patients with different gender, types, stages and lesion areas (P ＞0.05), while the levels of 25-(OH)D showed significant
difference of patients with different ages and disease courses (P ＜0.05). Conclusion Serum 25-(OH)D level is down-regulated
in AITD patients, and its expression levels are negatively correlated with the incidence rate of vitiligo; so the detection of serum
25-(OH)D level has high clinical guidance for the treatment of ITD combined with vitiligo.
更新日期/Last Update: 2020-10-30