[1]晓雪.局部他克莫司间断应用对特应性皮炎患者皮肤胶原合成的影响刘晓雪[J].中国美容医学,2021,(12):63-67.
　LIU Xiao-xue.Effect of Intermittent Application of Topical Tacrolimus on Skin Collagen Synthesis in Patients with Atopic Dermatitis[J].Medical Aesthetics and Beauty,2021,(12):63-67.
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局部他克莫司间断应用对特应性皮炎患者皮肤胶原合成的影响刘晓雪()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年12期
页码:
63-67
栏目:
出版日期:
2021-12-10

文章信息/Info

Title:
Effect of Intermittent Application of Topical Tacrolimus on Skin Collagen Synthesis in Patients with Atopic Dermatitis
文章编号:
1008-6455（2021）12-0063-04
作者:
晓雪
(湖北省襄州区人民医院皮肤科 湖北 襄阳 441000 )
Author(s):
LIU Xiao-xue
(Department of Dermatology,People’s Hospital of Xiangzhou District,Hubei Province, Xiangyang 441000,Hubei,China)
关键词:
特应性皮炎; 他克莫司; 间断应用; 皮肤胶原
Keywords:
atopic dermatitis;  tacrolimus;  intermittent application;  skin collagen
分类号:
R758.22
文献标志码:
A
摘要:
目的：探讨特应性皮炎（Atopic dermatitis,AD）患者局部他克莫司间断应用对皮肤胶原合成的影响。方法：选取2018年3月-2020年3月笔者医院接诊的104例AD患者，随机分为对照组（51例）与观察组（53例）。两组患者均采用他克莫司软膏进行第一阶段治疗，对照组第一阶段治疗完成后即停止用药，如病情复发，继续用药，用法与疗程同第一阶段；观察组第一阶段治疗完成后继续采用他克莫司软膏间歇维持治疗。比较两组治疗前，治疗第一阶段、第二阶段瘙痒情况及两组治疗第一阶段、第二阶段临床疗效及复发情况，比较两组治疗前后不同时间皮肤中胶原蛋白含量及两组不良反应情况。结果：两组第一阶段完成后，第二阶段开始后4、6个月瘙痒程度视觉模拟评分（VAS）比较，差异无统计学意义（P＞0.05）；第二阶段开始后1、2个月，观察组VAS评分低于对照组，差异有统计学意义（P＜0.05）；与治疗前比较，两组第一阶段完成后，第二阶段开始后第1、2、4、6个月VAS评分均降低，差异有统计学意义（P＜0.05）；两组第一阶段完成后，第二阶段开始后第4、6个月临床总有效率、复发率比较，差异无统计学意义（P＞0.05）；观察组第二阶段开始后1、2个月临床总有效率高于对照组，复发率低于对照组，差异有统计学意义（P＜0.05）；观察组首次复发时间长于对照组，复发次数少于对照组，复发持续时间短于对照组，差异有统计学意义（P＜0.05）。两组治疗前、第一阶段完成后，第二阶段开始后4、6个月皮肤中I型胶原蛋白含量比较，差异无统计学意义（P＞0.05）；观察组第二阶段开始后1、2个月皮肤中I型胶原蛋白含量高于对照组，差异有统计学意义（P＜0.05）；两组不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论：局部他克莫司间断应用可减轻患者瘙痒，有效延缓、减少AD复发，促进皮肤胶原合成，且安全可靠。
Abstract:
Objective To explore the effect of intermittent application of topical tacrolimus on skin collagen synthesis in patients with atopic dermatitis (AD). Methods A total of 104 AD patients admitted to our hospital from march 2018 to march 2020 were randomly divided into a control group (51 cases) and an observation group (53 cases). Both groups of patients were treated with tacrolimus ointment for the first stage of treatment. In the control group, the drug was stopped after the first stage of treatment, and if the disease recurred, the drug was continued. The usage and course of treatment were the same as the first stage. The observation group continued to use tacrolimus ointment for intermittent maintenance after the completion of the first phase of treatment. The pruritus in the first stage and the second stage before treatment in the two groups were compared. The clinical efficacy and recurrence of the two groups in the first and second stages of treatment were compared. The collagen content in the skin of the two groups before and after treatment at different times were compared. The adverse reactions of the two gro ups were compared. Results Before the treatment of the two groups, after the completion of the first stage, and 4 and 6 months after the start of the second stage, there were no significant differences in the visual analogue scale score (VAS) (P ＞0.05). The VAS scores of the observation group at 1, 2 months after the start of the second stage were lower than those of the control group (P＜0.05). Compared with before treatment, the VAS scores at 1, 2, 4, 6 months after the start of the second phase of the two groups were lower (P＜0.05). The total clinical effective rate after the completion of the first phase and 4 and 6 months after the start of the second phase, the recurrence rate 4 and 6 months after the start of the second phase of the two groups, the differences were not statistically significant (P＞0.05). The total clinical effective rate of the observation group were higher than those of the control group at 1 and 2 months after the start of the second phase, of which the recurrence rate were lower than those of the control group (P＜0.05). The first recurrence time of the observation group was longer than that of the control group, which of the number of recurrences was less than that of the control group, which of the recurrence duration was shorter than that of the control group (P＜0.05). There were no significant differences in skin type I collagen content between the two groups before the treatment, after the completion of the first stage, and 4 and 6 months after the start of the second stage (P＞0.05). The content of type I collagen in the skin of the observation group was higher than those in the control group 1 and 2 months after the second phase (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Intermittent application of local tacrolimus can relieve itching in patients, effectively delay and reduce AD recurrence, promote skin collagen synthesis, and is safe and reliable.

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更新日期/Last Update: 2022-01-17