[1]滕 伟,庞 超,韩海莉.强脉冲光联合氨甲环酸凝胶贴治疗面部黄褐斑疗效观察[J].中国美容医学,2023,(6):74-78.
　TENG Wei,PANG Chao,HAN Haili.Effects of Intense Pulsed Light Combined with Tranexamic Acid Gel Patch in the Treatment of Facial Melasma[J].Medical Aesthetics and Beauty,2023,(6):74-78.
点击复制

强脉冲光联合氨甲环酸凝胶贴治疗面部黄褐斑疗效观察()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年6期
页码:
74-78
栏目:
出版日期:
2023-06-10

文章信息/Info

Title:
Effects of Intense Pulsed Light Combined with Tranexamic Acid Gel Patch in the Treatment of Facial Melasma
文章编号:
1008-6455（2023）06-0074-04
作者:
滕 伟; 庞 超; 韩海莉
(沧州市妇幼保健院皮肤美容科 河北 沧州 061001 )
Author(s):
TENG Wei; PANG Chao; HAN Haili
(Department of Dermatology,Cangzhou Maternal and Child Health Hospital,Cangzhou 061001,Hebei,China)
关键词:
强脉冲光; 氨甲环酸凝胶贴; 黄褐斑; 皮肤生理参数; 皮肤菌群
Keywords:
intense pulsed light;  tranexamic acid gel patch;  chloasma;  skin physiological parameters;  skin fl ora
分类号:
R751
文献标志码:
A
摘要:
目的：观察强脉冲光联合氨甲环酸凝胶贴治疗黄褐斑的效果。方法：选取2020年6月-2021年6月笔者医院收治的80例 黄褐斑患者作为研究对象，经随机数字表法分为观察组和对照组各40例。对照组患者予以强脉冲光治疗，观察组在对照组基 础上加用氨甲环酸凝胶贴。比较两组患者治疗前、治疗2个月后临床效果[黄褐斑面积及严重程度评分（MASI）、皮损颜色、 皮损面积]、皮肤状态（VISIA皮肤图像分析）、皮肤生理参数[经皮水分丢失（TEWL）、表皮油脂含量、角质层含水量]、皮 肤菌群（微球菌、需氧革兰阴性杆菌、痤疮丙酸杆菌）水平，统计两组患者治疗2个月内不良反应发生情况。结果：治疗2 个月后，两组患者MASI、皮损颜色、皮损面积、VISIA皮肤图像分析结果（色素沉着、色斑、毛孔、纹理水平）、TEWL水 平显著低于治疗前，且除TEWL外，观察组其余指标均显著低于对照组（P＜0.05），两组患者TEWL水平比较差异无统计学 意义（P＞0.05）；两组患者角质层含水量显著高于治疗前（P＜0.05），两组比较差异无统计学意义（P＞0.05）；观察组 患者皮肤表面微球菌、痤疮丙酸杆菌水平显著低于治疗前，且微球菌水平显著低于对照组（P＜0.05），痤疮丙酸杆菌水平 两组比较差异无统计学意义（P＞0.05）；观察组患者表皮油脂含量显著高于治疗前，且显著高于对照组（P＜0.05），对照 组与治疗前差异无统计学意义（P＞0.05）；两组患者需氧革兰阴性杆菌水平与治疗前比较差异无统计学意义（P＞0.05）。 治疗2个月内，两组患者不良反应发生情况比较差异无统计学意义（P＞0.05）。结论：强脉冲光联合氨甲环酸凝胶贴治疗黄 褐斑患者临床效果较好，可有效改善皮损，修复皮肤屏障，且安全性较好。
Abstract:
Objective To observe the eff ects of intense pulsed light combined with tranexamic acid gel patch in the treatment of chloasma. Methods 80 patients with chloasma who were treated in the hospital between June 2020 and June 2021 were selected as the research subjects and were divided into an observation group (40 cases) and a control group (40 cases) by the random number table method. The patients in the control group were treated with intense pulsed light, and the patients in the observation group were additionally given tranexamic acid gel patches based on the control group. The clinical eff ects [Melasma Area and Severity Index (MASI), skin lesion color, skin lesion area], skin status (VISIA skin image analysis), skin physiological parameters [trans epidermal water loss (TEWL), epidermal grease content, water content of stratum corneum] and skin fl ora (Micrococcus, aerobic Gram-negative bacilli, propionibacterium acnes) were compared between the two groups before treatment and after 2 months of treatment. The occurrence of adverse reactions in the two groups of patients was statistically analyzed within 2 months of treatment. Results After 2 months of treatment, the MASI, skin lesion color, skin lesion area, VISIA skin image analysis results (pigmentation, stains, pores, texture) and TEWL in the two groups were signifi cantly lower than those before treatment, and the other indicators except for TEWL in the observation group were signifi cantly lower than those in the control group (P ＜0.05), and there was no signifi cant diff erence in TEWL between the two groups (P ＞0.05). The water content of stratum corneum in both groups was signifi cantly more than that before treatment (P ＜0.05), but there was no signifi cant diff erence between the groups (P ＞0.05). The levels of Micrococcus and Propionibacterium acnes on the skin surface were signifi cantly lower in the observation group than those before treatment, and the level of Micrococcus was signifi cantly lower than that in the control group (all P ＜0.05), but the diff erence in the level of Propionibacterium acnes was not signifi cant between the two groups (P＞0.05). The content of epidermal grease in the observation group was signifi cantly more than that before treatment and was signifi cantly more than that in the control group (P ＜0.05), but the diff erence was not signifi cant in the control group compared to before treatment(P ＞0.05). The level of aerobic Gram-negative bacilli in the two groups was not significantly different from that before treatment, and there was no significant difference between the two groups (P＞0.05). Within 2 months of treatment, there were no statistical diff erences in the occurrence of adverse reactions between the two groups (P ＞0.05). Conclusion The combination of intense pulsed light and tranexamic acid gel patch has good clinical eff ects on patients with chloasma, and can eff ectively improve the skin lesions and repair the skin barriers, with good safety.

相似文献/References:

[1]陈劲奕,刘海霞,杨 涛,等. 盐酸米诺环素联合复方甘草酸苷序贯强脉冲光治疗Ⅰ型玫瑰痤疮疗效观察[J].中国美容医学,2018,(04):46.
　CHEN Jin-yi,LIU Hai-xia,YANG Tao,et al. Efficacy of Minocycline Hydrochloride Combined with Compound Glycyrrhizin in Sequential Pulsed Light Therapy for Acne Rosacea[J].Medical Aesthetics and Beauty,2018,(6):46.
[2]石莹莹,陈 炜,王露萍,等. 强脉冲光联合氨甲环酸治疗面部黄褐斑MASI评分观察[J].中国美容医学,2018,(05):36.
　SHI Ying-ying,CHEN Wei,WANG Lu-ping,et al. Observation on MASI Score of Intense Pulsed Light IPL Combined with Oral Transamin in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(6):36.
[3]黄朝卫,解翠林,石 年,等. 女性黄褐斑的临床特点及点阵激光治疗的效果分析[J].中国美容医学,2018,(06):85.
　HUANG Chao-wei,XIE Cui-lin,SHI Nian,et al.The Clinical Characteristics of Female Chloasma and Cosmetic Effect of Dot Matrix Laser Treatment[J].Medical Aesthetics and Beauty,2018,(6):85.
[4]文丽萍,周书帆,邓 映,等. 短波理疗联合强脉冲光治疗面部糖皮质激素依赖性皮炎临床观察[J].中国美容医学,2018,(11):36.
　WEN Li-ping,ZHOU Shu-fan,DENG Ying,et al. Clinical Observation of Desensitization Apparatus Combined with Intense PulsedLight in the Treatment of Facial Glucocorticosteroid-dependent Dermatitis[J].Medical Aesthetics and Beauty,2018,(6):36.
[5]马慧敏,陈 军,冯仁洋.2013年至2017年1 766例就医者首次光电美容治疗情况分析[J].中国美容医学,2018,(11):43.
　MA Hui-min,CHEN Jun,FENG Ren-yang.Analysis the Aim of 1 766 Visitors of Cosmetic Department from 2013 to 2017[J].Medical Aesthetics and Beauty,2018,(6):43.
[6]陈 燕,李 生,马 明. 强脉冲光联合长脉宽Nd:YAG激光治疗面部毛细血管扩张症疗效观察[J].中国美容医学,2019,(03):54.
　CHEN Yan,LI Sheng,MA Ming. Therapeutic Effect of Intense Pulsed Light Combined with Long Pulse Width Nd:YAGLaser on Facial Telangiectasia[J].Medical Aesthetics and Beauty,2019,(6):54.
[7]刘 冰 齐 婧 综述,李承新 审校. 黄褐斑的光电治疗进展[J].中国美容医学,2019,(05):15.
　LIU Bing,QI Jing,LI Cheng-xin. Progress in Laser and Light Therapy of Melasma[J].Medical Aesthetics and Beauty,2019,(6):15.
[8]刘丽华,杨万军,徐 琪. 超分子水杨酸联合强脉冲光治疗面部痤疮疗效观察[J].中国美容医学,2019,(05):57.
　LIU Li-hua,YANG Wan-jun,XU Qi. Therapeutic Effect of Supramolecular Salicylic Acid Combined with Intense PulseLight in the Treatment of Facial Acne[J].Medical Aesthetics and Beauty,2019,(6):57.
[9]张嘉文 刘子菁 王小燕 Juliandri刘韵祎 马仁燕 综述,许 阳 审校. 玫瑰痤疮的光电治疗研究进展[J].中国美容医学,2019,(05):159.
　ZHANG Jia-wen,LIU Zi-jing,WANG Xiao-yan,et al. Research Progress of Photoelectric for Rosacea[J].Medical Aesthetics and Beauty,2019,(6):159.
[10]邹道佩,蒲以欢,陈阳美,等. 神经酰胺喷剂在强脉冲光嫩肤术后皮肤修复中的疗效观察[J].中国美容医学,2019,(06):40.
　ZOU Dao-pei,PU Yi-huan,CHEN Yang-mei,et al. The Effect of Ceramide Spray on Skin Repair after Intense Pulse Light[J].Medical Aesthetics and Beauty,2019,(6):40.

更新日期/Last Update: 2023-07-10