[1]周 星,姚新宇,粟玉珍.他克莫司联合窄谱UVB治疗特应性皮炎的疗效观察[J].中国美容医学,2024,(10):36-40.
　ZHOU Xing,YAO Xinyu,LI Yuzhen.Observation on Effi cacy of Tacrolimus Combined with Narrow-band UVB in Treating Atopic Dermatitis[J].Medical Aesthetics and Beauty,2024,(10):36-40.
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他克莫司联合窄谱UVB治疗特应性皮炎的疗效观察()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年10期
页码:
36-40
栏目:
出版日期:
2024-09-26

文章信息/Info

Title:
Observation on Effi cacy of Tacrolimus Combined with Narrow-band UVB in Treating Atopic Dermatitis
文章编号:
1008-6455（2024）10-0036-05
作者:
周 星1; 姚新宇2; 粟玉珍3
(1.北京市第六医院皮肤科 北京 100007;2.北京大学第一医院皮肤科,北京市皮肤病分子诊断重点实验室 国家皮肤与免疫 疾病临床医学研究中心 北京 100034;3.哈尔滨医科大学附属第二医院皮肤科 黑龙江 哈尔滨 150001)
Author(s):
ZHOU Xing1 ;  YAO Xinyu2 ;  LI Yuzhen3
( 1.Department of Dermatology, Beijing No.6 Hospital, Beijing 100007, China; 2.Department of Dermatology(Vennerology), Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, Beijing 100034, China; 3.Department of Dermatology, the 2nd Affi liated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China )
关键词:
特应性皮炎; 他克莫司; 窄谱UVB; 美学效果
Keywords:
atopic dermatitis;  tacrolimus;  narrow-band UVB;  aesthetic eff ect
分类号:
R758.2
文献标志码:
A
摘要:
目的：探究他克莫司联合窄谱UVB治疗特应性皮炎的疗效。的特应性皮炎患者，并按照简单随机化随机分为A组（采用他克莫司治疗，40例）、B组（采用润肤霜联合窄谱UVB治疗， 40例）和C组（采用他克莫司联合窄谱UVB治疗，40例），持续治疗2个月。于治疗前、治疗1个月和治疗2个月后，比较三组 特应性皮炎患者的临床体征[特应性皮炎评分量表（Scoring atopic dermatitis index，SCORAD）、中文版特应性皮炎控制 工具量表（Chinese version of atopic dermatitis control tool，ADCT）]、瘙痒情况[峰值瘙痒数字评定量表（Peak pruritis-numerical rating scale，PP-NRS）]、细胞因子[血清载脂蛋白A1（Apolipoprotein A1，ApoA1）、载脂蛋白B （Apolipoprotein B，ApoB）、白细胞介素4（IL-4）、白细胞介素10（IL-10）]水平、美学效果[皮炎整体面积、客观体征评 分（红斑、表皮剥脱、苔藓样变）]和生活质量[皮肤病生活质量量表（DLQI）]。记录治疗期间三组患者的不良反应，比较 其治疗后3个月随访期间复发情况。结果：治疗1个月和治疗2个月后，三组的SCORAD、ADCT、PP-NRS、ApoB、IL-4、IL-10、 皮炎整体面积、进行客观体征评分和DLQI评分均较治疗前显著下降，且C组显著低于A组和B组（均P＜0.05）；三组的ApoA1均较治 疗前显著提高，且C组显著高于A组和B组（均P＜0.05）。治疗期间，三组患者的不良反应发生率无显著差异（P＞0.05）；治疗后 3个月随访期间，C组的复发情况显著低于A组和B组（P＜0.05）。结论：他克莫司联合窄谱UVB治疗在特应性皮炎患者中具有 显著的治疗效果，能够有效地缓解特应性皮炎症状和瘙痒情况，改善患者生活质量，提升美学效果。
Abstract:
Objective To explore the efficacy of tacrolimus combined with narrow-band UVB in the treatment of atopic dermatitis. Methods A total of 120 patients with atopic dermatitis who were treated at the author’s hospital from February 2021 to December 2022 were selected and randomly divided into three groups using a simple randomization method: group A (tacrolimus, 40 cases), group B (moisturizer combined with narrow-band UVB, 40 cases), and group C (tacrolimus combined with narrow-band UVB, 40 cases). All three groups were treated continuously for 2 months. Clinical signs [Scoring Atopic Dermatitis Index (SCORAD), Chinese version of Atopic Dermatitis Control Tool (ADCT)], pruritus [Peak Pruritus-Numerical Rating Scale (PP-NRS)], cytokines [serum apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), interleukin-4 (IL-4), interleukin-10 (IL-10)], aesthetic eff ects [overall area of dermatitis, scores of objective signs (erythema, exfoliation, lichenoid change)], and quality of life [Dermatological Life Quality Index (DLQI)] were compared among the three groups before treatment, and after 1 month and 2 months of treatment. The adverse reactions in the three groups were recorded during treatment, and recurrence was assessed during a 3-month follow-up period after treatment. Results After 1 and 2 months of treatment, SCORAD, ADCT, PP-NRS, ApoB, IL-4, IL-10, overall dermatitis area, objective sign scores, and DLQI scores in all three groups were signifi cantly reduced compared to before treatment, with group C showing signifi cantly lower levels in these indicators compared to group A and group B (all P＜0.05). ApoA1 levels were signifi cantly increased in all three groups compared to before treatment, with group C showing signifi cantly higher levels than groups A and B (all P＜0.05). There were no signifi cant diff erences in the incidence rates of adverse reactions among the three groups during treatment (P＞0.05). The recurrence rate in group C during the 3-month follow-up period was signifi cantly lower than that in group A and group B (P＜0.05). Conclusion Tacrolimus combined with narrow-band UVB has a signifi cant therapeutic eff ect on patients with atopic dermatitis, eff ectively relieving symptoms and pruritus, improving quality of life, and enhancing aesthetic outcomes.

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更新日期/Last Update: 2024-09-30