[1]胡耀华,张 超,王红梅,等. VSD联合表皮生长因子治疗皮肤软组织缺损的效果研究[J].中国美容医学,2019,(03):4-7.
　HU Yao-hua,ZHANG Chao,WANG Hong-mei,et al.The Effect of VSD Combined with Epidermal Growth Factor in Treatment of Skin andSoft Tissue Defects[J].Medical Aesthetics and Beauty,2019,(03):4-7.
点击复制

 VSD联合表皮生长因子治疗皮肤软组织缺损的效果研究
(/HTML)
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年03期
页码:
4-7
栏目:
出版日期:
2019-03-11

文章信息/Info

Title:
The Effect of VSD Combined with Epidermal Growth Factor in Treatment of Skin and
Soft Tissue Defects
文章编号:
1008-6455（2019）03-0004-03
作者:
 胡耀华1; 张 超2; 王红梅3; 卓书伟1; 符春苗1; 杨 梅4
Author(s):
HU Yao-hua1; ZHANG Chao2; WANG Hong-mei3; ZHUO Shu-wei1; FU Chun-miao1; YANG Mei4
关键词:
[关键词]负压封闭引流; 表皮生长因子; 皮肤软组织缺损; 清创; 皮片移植修复
Keywords:
Key words: vacuum sealing drainage;  epidermal growth factor;  skin and soft tissue defects;  debridement;  skin graft repair
分类号:
R622
文献标志码:
A
摘要:

[摘要]目的：探讨负压封闭引流（Vacuum sealing drainage，VSD）联合表皮生长因子治疗皮肤软组织缺损的效果。方法：
选取2017年1月-2018年1月治疗的四肢皮肤软组织缺损患者102例，根据最终采取的治疗方案分为联合组（n =41）、VSD组
（n =31）和表皮生长因子组（n =30），所有患者行手术清创并行自体皮片移植修复，联合组给予VSD联合表皮生长因子治
疗，VSD组给予单纯VSD治疗，表皮生长因子组给予表皮生长因子治疗，观察各组植皮存活率、瘢痕评分及疼痛程度，同时
检测治疗前后干扰素-γ（Interferon-γ，IFN-γ）、白细胞介素-6（Interleukin-6，IL-6）和C反应蛋白（C-reactive
protein，CRP）。结果：联合组植皮存活率为95.12%（39/41），明显高于VSD组的74.19%（23/31）和表皮生长因子组的
73.33%（22/30），差异有统计学意义（P ＜0.05）。联合组瘢痕柔软度、血管分布、厚度、色泽评分及总分明显低于VSD组
和表皮生长因子组，差异有统计学意义（P ＜0.05）。各组治疗后7d IFN-γ、IL-6和CRP明显高于治疗前，差异有统计学意
义（P ＜0.05）；联合组治疗后7d IFN-γ、IL-6和CRP明显低于VSD组和表皮生长因子组，差异有统计学意义（P ＜0.05）。
联合组术后1周、1个月VAS评分明显低于VSD组和表皮生长因子组，差异有统计学意义（P ＜0.05）。结论：VSD联合表皮生长
因子治疗皮肤软组织缺损有较好的效果，值得临床应用。
Abstract:
Abstract: Objective To investigate the effect of vacuum sealing drainage (VSD) combined with epidermal growth factor in
the treatment of skin and soft tissue defects. Methods 102 patients with soft tissue defects of the extremities were treated
from January 2017 to January 2018, according to the final treatment, the patients were divided into the combined group
(n =41), the VSD group (n =31) and the epidermal growth factor group (n =30), all patients underwent surgical debridement and
autologous skin graft repair. The combined group was treated with VSD combined with epidermal growth factor, the VSD
group was treated with VSD alone, the epidermal growth factor group was treated with epidermal growth factor. The survival
rate of skin graft, scar score and the degree of pain in the each groups were observed, interferon-γ(IFN-γ), interleukin-6
(IL-6) and C-reactive protein(CRP) were detected before and after treatment. Results The survival rate of skin graft in the
combined group was 95.12%(39/41), which was significantly higher than those in the VSD group and the epidermal growth
factor group[74.19%(23/31), 73.33%(22/30)], the differences were statistically significant (P ＜0.05). Scar softness, vascular
distribution, thickness, color score and total score in the combined group were significantly lower than those in the VSD group
and the epidermal growth factor group(P ＜0.05). The levels of IFN-γ, IL-6 and CRP in each group were significantly higher
at 7d after treatment than those before treatment(P ＜0.05). The levels of IFN-γ, IL-6 and CRP in the combined group were
significantly lower than those in the VSD group and the epidermal growth factor group at 7d after treatment(P ＜0.05). The VAS
score of combined group was significantly lower than that of VSD group and epidermal growth factor group at 1 week and 1
month after operation(P ＜0.05). Conclusion VSD combined with epidermal growth factor is effective in treating skin and soft
tissue defects, and is worthy of clinical application.

相似文献/References:

[1]孙同祖. 植皮联合负压封闭引流技术修复深度烧伤创面的应用观察及并发症分析[J].中国美容医学,2018,(04):4.
　SUN Tong-zu. Application of Skin Grafting Combined with Negative Pressure Closed Drainage for Deep Burn Wounds and Analysis of its Complications[J].Medical Aesthetics and Beauty,2018,(03):4.
[2]曾 芳,杨 英,马丽莎. 负压封闭引流技术联合持续冲洗治疗骨折合并皮肤软组织缺损的效果观察[J].中国美容医学,2018,(05):61.
　ZENG Fang,YANG Ying,MA Li-sha. Effect of Vacuum Sealing Drainage Combined with Continuous Irrigation in the Treatment of Fracture and Skin Soft Tissue Defect[J].Medical Aesthetics and Beauty,2018,(03):61.
[3]孙充洲,王帅道,赵婷慧,等.二次负压封闭引流对小儿大面积深Ⅱ度烧伤创面愈合的疗效研究[J].中国美容医学,2019,(03):31.
　SUN Chong-zhou,WANG Shuai-dao,ZHAO Ting-hui,et al. Effect of Twice Vacuum Sealing Drainage on Large Area Deep Ⅱ Degree BurnWounds in Children[J].Medical Aesthetics and Beauty,2019,(03):31.
[4]陈 敏,徐进前. 黄金微针联合外用透明质酸及表皮生长因子在面部皮肤年轻化中的应用[J].中国美容医学,2019,(05):101.
　CHEN Min,XU Jin-qian. Application of Gold Microneedle Combined with Topical Hyaluronic Acid andEpidermal Growth Factor in Rejuvenation of Facial Skin[J].Medical Aesthetics and Beauty,2019,(03):101.
[5]刘 刚,王 杨,左 娜,等. 负压封闭引流技术联合富血小板纤维蛋白修复巨大皮肤脓肿清创后难愈性创面[J].中国美容医学,2019,(12):1.
　LIU Gang,WANG Yang,ZUO Na,et al. Vacuum Assisted Closure Combined with Platelet-rich Fibrin in the Repair of ChronicWound after Huge Skin Abscess Debridement[J].Medical Aesthetics and Beauty,2019,(03):1.
[6]李 欣,朱桂玲. VSD对深度烧伤后创面的修复效果及术后护理方法探讨[J].中国美容医学,2020,(2):145.
　LI Xin,ZHU Gui-ling. Study on the Effect of Vacuum Sealing Drainage(VSD) in Repairing Deep BurnWounds and the Nursing Methods after Operation[J].Medical Aesthetics and Beauty,2020,(03):145.
[7] 陆 扬. 自体ADSCs联合外膜敷贴对老年患者慢性创面愈合的影响[J].中国美容医学,2020,(6):63.
　 LU Yang. Effect of Autologous ADSCs Combined with Adventitia Dressing on Chronic WoundHealing in the Elderly[J].Medical Aesthetics and Beauty,2020,(03):63.
[8] 雷德会,杨丽英. 浸浴对大面积烧伤残余创面感染及愈合的影响分析[J].中国美容医学,2021,(3):73.
　 LEI De-hui,YANG LI-ying. Effect of Bathing on Infection and Healing of Large Area Burn Residual Wounds[J].Medical Aesthetics and Beauty,2021,(03):73.
[9] 杨丽英,罗 鹏,陈 玲. 富血小板血浆对难治性皮肤溃疡创面愈合及肉芽组织中TGF-1及EGF表达的影响[J].中国美容医学,2021,(5):48.
　[J].Medical Aesthetics and Beauty,2021,(03):48.
[10] 吴 丽,江婷婷,李 静,等. 射频微针联合表皮生长因子治疗中重度痤疮疗效分析及对ECCA评分的影响[J].中国美容医学,2021,(8):54.
　 WU Li,JIANG Ting-ting,LI Jing,et al. Efficacy Analysis of Radiofrequency Microneedling Combined with EpidermalGrowth Factor in the Treatment of Moderate to Severe Acne and its Influence onECCA Score[J].Medical Aesthetics and Beauty,2021,(03):54.

更新日期/Last Update: 2019-03-29