[1]王 丽,刘 俊,李姗姗,等.光动力疗法联合CO2激光治疗尖锐湿疣的疗效观察及美学评价[J].中国美容医学,2021,(12):78-81.
　WANG Li,LIU Jun,LI Shan-shan,et al.Clinical Observation and Medical Aesthetic Evaluation of Photodynamic Therapy Combined with CO2 Laser in the Treatment of Condyloma Acuminatum[J].Medical Aesthetics and Beauty,2021,(12):78-81.
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光动力疗法联合CO2激光治疗尖锐湿疣的疗效观察及美学评价()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年12期
页码:
78-81
栏目:
出版日期:
2021-12-10

文章信息/Info

Title:
Clinical Observation and Medical Aesthetic Evaluation of Photodynamic Therapy Combined with CO2 Laser in the Treatment of Condyloma Acuminatum
文章编号:
1008-6455（2021）12-0078-03
作者:
王 丽; 刘 俊; 李姗姗; 王瑞丽; 王晓云
(阳光融和医院皮肤科 山东 潍坊 261000 )
Author(s):
WANG Li; LIU Jun; LI Shan-shan; WANG Rui-li; WANG Xiao-yun
(Department of Dermatology,Sunshine Fusion Hospital,Weifang 261000,Shandong,China)
关键词:
尖锐湿疣; 光动力学疗法; CO2激光; 美学评价; 血清增殖细胞核抗原; 血管内皮生长因子
Keywords:
condyloma acuminatum;  photodynamic therapy;  CO2 laser ablation;  aesthetic evaluation;  serum proliferating cell nuclear antigen;  vascular endothelial growth factor
分类号:
R711.72
文献标志码:
A [
摘要:
目的：研究光动力疗法联合CO2激光治疗尖锐湿疣的美学评价及对血清增殖细胞核抗原（PCNA）和血管内皮生长因子（VEGF）表达的影响。方法：选取2016年6月-2019年6月于笔者医院接受治疗的156例尖锐湿疣患者，采用随机数字表法将患者分为联合组和激光组，每组78例。激光组给予CO2激光治疗，联合组给予光动力联合CO2激光治疗，持续治疗3周后，比较两组临床疗效、血清PCNA水平、VEGF表达水平，美学评价指标评分及不良反应。结果：联合组总有效率（97.44%）明显高于激光组（78.21%），差异有统计学意义(P＜0.05)；治疗前，两组患者PCNA、VEGF表达水平、医学美学指标评分比较差异无统计学意义（P＞0.05）；治疗后，两组PCNA、VEGF水平与治疗前比较显著下降，且联合组PCNA、VEGF水平明显低于激光组，差异有统计学意义(P＜0.05)；两组皮肤解剖形态、排尿功能、性功能、皮肤色泽及视觉美感评分与治疗前比较显著上升，且联合组明显高于激光组，差异有统计学意义(P＜0.05)；联合组总不良反应发生率（6.41%）、半年复发率（5.13%）显著低于激光组（26.92%、42.31%），差异有统计学意义(P＜0.05)。结论：光动力疗法联合CO2激光治疗尖锐湿疣疗效确切，能有效改善美学效果，调节机体VEGF、PCNA表达水平，降低副反应，值得临床推广应用。
Abstract:
Objective To investigate the effects of photodynamic therapy combined with CO 2 laser ablation on aesthetic evaluation and the expression of serum proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) of patients with condyloma acuminatum. Methods 156 patients with condyloma acuminatum in our hospital from June 2016 to June 2019 were enrolled, and divided into two groups by random number table methods, each with 78 cases. Laser group received CO 2 laser ablation, while combined group received photodynamic therapy combined with CO 2 laser ablation. Treatment in both groups lasted for 3 weeks. Then the clinical efficacy, serum PCNA and VEGF levels, medical aesthetic evaluation indica tors, adverse reaction rate and side effects were compared between groups. Results The clinical efficacy of combined group was higher than that of laser group (97.44% vs 78.21%, P ＜0.05). Serum PCNA, VEGF expression levels and medical aesthetics scores had no significant difference between groups before treatment (P＞0.05). After treatment, serum PCNA and VEGF expression levels were decreased in both groups, and were lower in combined group than in control group (P＜0.05). Skin anatomical morphology, urination function, sexual function, skin color and visual beauty scores were increased in both groups after treatment, and were higher in combined group than in control group (P＜0.05). The total adverse reactions and half-year recurrence rates of combined group were significantly lower than those of laser group (6.41% vs 26.92%, 5.13% vs 42.31%, P ＜0.05). Conclusion Photodynamic therapy combined with CO 2 laser ablation can effectively ameliorate the aesthetic evaluation and the expression of serum VEGF and PCNA of patients with condyloma acuminatum, with fewer side effects, so it is worthy of clinical promotion.

相似文献/References:

[1]沈秀兰.CO2激光联合不同剂量干扰素治疗尖锐湿疣临床疗效研究[J].中国美容医学,2019,(07):51.
　SHEN Xiu-lan. Clinical Efficacy of CO2 Laser Combined with Different Doses of Interferon in the Treatment of Condyloma Acuminatum[J].Medical Aesthetics and Beauty,2019,(12):51.

更新日期/Last Update: 2022-01-18