[1]李忠兴,武凤莲.富血小板血浆局部注射联合血小板凝胶覆盖治疗慢性难愈性创面[J].中国美容医学,2023,(8):67-70.[doi:10.15909/j.cnki.cn61-1347/r.005837]
　I Zhongxing,WU Fenglian.Local Injection of Platelet-rich Plasma Combined with Autologous Platelet Gel Covering for the Treatment of Dermal Chronic Ulcer?/html>[J].Medical Aesthetics and Beauty,2023,(8):67-70.[doi:10.15909/j.cnki.cn61-1347/r.005837]
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富血小板血浆局部注射联合血小板凝胶覆盖治疗慢性难愈性创面()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年8期
页码:
67-70
栏目:
出版日期:
2023-08-10

文章信息/Info

Title:
Local Injection of Platelet-rich Plasma Combined with Autologous Platelet Gel Covering for the Treatment of Dermal Chronic Ulcer?/html>
文章编号:
1008-6455(2023)08-0067-04
作者:
李忠兴; 武凤莲
(秦皇岛市第一医院烧伤整形美容外科 河北 秦皇岛 066000 )
Author(s):
I Zhongxing; WU Fenglian
(Department of Burn and Plastic Cosmetic Surgery,the First Hospital of Qinhuangdao,Qinhuangdao 066000,Hebei,China)
关键词:
富血小板血浆; 局部注射; 血小板凝胶; 慢性难愈性创面; 炎症反应; 生长因子
Keywords:
platelet-rich plasma;  local injection;  autologous platelet gel;  dermal chronic ulcer;  infl ammatory response;  growth factors
分类号:
R622
DOI:
10.15909/j.cnki.cn61-1347/r.005837
文献标志码:
A
摘要:
目的：探讨富血小板血浆（Platelet-rich plasma，PRP）局部注射联合血小板凝胶（Autologous plateletrichgel，APG）治疗慢性难愈性创面（Dermal chronic ulcer，DCU）的疗效。方法：选取2019年2月-2022年2月笔者医院收 治的113例DCU患者为研究对象，按随机数表法分为联合组（n=58）和对照组（n=55），两组均给予常规治疗，对照组在此基 础上给予APG治疗，联合组在对照组基础上联合PRP局部注射治疗，比较两组治疗后的临床疗效、创面愈合情况、血清炎症因 子[C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素1β（IL-1β）]水平、血清生长因子[血管内皮生长因 子（VEGF）、血清促红细胞生成素（EPO）、血清透明质酸（HA）]水平及不良反应发生情况。结果：治疗后，联合组感染控 制时间、创面愈合时间及住院时间均明显短于对照组（P＜0.05）。治疗2周后，联合组总有效率高于对照组（P＜0.05）； 两组CRP、TNF-α和IL-1β水平均降低（P＜0.05），且联合组均明显低于对照组（P＜0.05）；两组VEGF、EPO和HA水平均升 高（P＜0.05），且联合组均明显高于对照组（P＜0.05）。联合组不良反应总发生率为5.17%，对照组为10.91%，两组比较 差异无统计学意义（P＞0.05）。结论：PRP局部注射联合APG治疗DCU疗效显著，可有效缓解创面炎症，提高血清生长因子水 平，促进创面愈合，安全性好，值得临床推广应用。
Abstract:
Objective To explore the effi cacy of local injection of platelet-rich plasma (PRP) combined with autologous platelet gel (APG) in the treatment of dermal chronic ulcer (DCU). Methods 113 patients with DCU admitted to the author’s hospital from February 2019 to February 2022 were selected as the research objects,and all the selected patients were divided into the combined group (n=58) and the control group (n=55) by the random number table method. Both groups were given routine treatment,and the control group was given APG treatment on this basis while the combined group was combined with PRP local injection on the basis of the control group. The clinical effi cacy,wound healing,levels of serum infl ammatory factors [C-reactive protein (CRP),tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β)],serum growth factors [vascular endothelial growth factor (VEGF),serum erythropoietin (EPO),serum hyaluronic acid (HA)] and occurrence of adverse reactions were compared between the two groups after treatment. Results After treatment,The infection control time,wound healing time and hospital stay were significantly shorter in the combined group than those in the control group (P ＜0.05).After 2 weeks of treatment,the total eff ective rate of the combined group was higher than that of the control group (P ＜0.05). The levels of CRP,TNF-α and IL-1β in the two groups were signifi cantly decreased (P ＜0.05),and the levels in the combined group were signifi cantly lower than those in the control group (P ＜0.05). The levels of VEGF,EPO and HA were signifi cantly increased in the two groups (P ＜0.05),and the levels were signifi cantly higher in the combined group compared to the control group (P ＜0.05). The total incidence rate of adverse reactions was 5.17% in the combined group and that in the control group was 10.91% (P＞0.05). Conclusion Local injection of PRP combined with APG has a signifi cant effi cacy in the treatment of DCU,and it can eff ectively relieve the degree of wound infl ammation,increase the concentrations of growth factors in wound,and promote the wound healing. It has good safety and is worthy of clinical promotion and application.

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更新日期/Last Update: 2023-08-30