[1]刘 可,高以红,朱红柳,等.复方首乌蒺藜汤联合火针及他克莫司治疗稳定期白癜风疗效分析[J].中国美容医学,2023,(10):78-82.[doi:10.15909/j.cnki.cn61-1347/r.005940]
　LIU Ke,GAO Yihong,ZHU Hongliu,et al.Effi cacy of Compound Shouwu Jili Decoction Combined with Fire Needle and Tacrolimus in the Treatment of Stable Vitiligo[J].Medical Aesthetics and Beauty,2023,(10):78-82.[doi:10.15909/j.cnki.cn61-1347/r.005940]
点击复制

复方首乌蒺藜汤联合火针及他克莫司治疗稳定期白癜风疗效分析()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年10期
页码:
78-82
栏目:
出版日期:
2023-10-10

文章信息/Info

Title:
Effi cacy of Compound Shouwu Jili Decoction Combined with Fire Needle and Tacrolimus in the Treatment of Stable Vitiligo
文章编号:
1008-6455（2023）10-0078-05
作者:
刘 可; 高以红; 朱红柳; 毛秋霞
(江阴市中医院皮肤科 江苏 江阴 214400 )
Author(s):
LIU Ke; GAO Yihong; ZHU Hongliu; MAO Qiuxia
(Department of Dermatology,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin 214400,Jiangsu,China)
关键词:
复方首乌蒺藜汤; 火针; 稳定期白癜风; 皮损色素
Keywords:
compound Shouwu Jili decoction;  fi re needle;  stable vitiligo;  skin pigment
分类号:
R758.4+ 1
DOI:
10.15909/j.cnki.cn61-1347/r.005940
文献标志码:
A
摘要:
目的：探讨复方首乌蒺藜汤联合火针及他克莫司治疗稳定期白癜风的疗效。方法：选取笔者医院2019年1月-2021年1 月收治的125例稳定期白癜风患者，按照随机数字表法分为对照组63例（火针治疗）和观察组62例（火针+复方首乌蒺藜汤 治疗）。此外，两组均给予局部外用0.1%他克莫司软膏涂抹治疗。治疗6个月后，比较两组临床疗效，治疗前后两组间中医 证候积分，皮损色素恢复效果，T淋巴细胞亚群、氧化应激指标水平，记录不良反应发生情况。结果：治疗后，观察组总有 效率（91.94%）显著高于对照组（79.37%）（P＜0.05）；治疗后，两组各项中医证候积分均下降（P＜0.05），且观察组 治疗后各项中医证候积分均低于对照组（P＜0.05）；治疗后，两组靶皮损白斑面积均显著下降（P＜0.05），皮损色素积 分显著上升（P＜0.05），且观察组治疗后靶皮损白斑面积小于对照组，皮损色素积分高于对照组（P＜0.05）；治疗后， 两组CD3+ 、CD4+ 、CD4+ /CD8+ 均显著上升（P＜0.05），CD8+ 显著下降（P＜0.05），且观察组改善优于对照组（P＜0.05）；治 疗后，两组超氧化物歧化酶（Superoxidedismutase，SOD）、血浆总抗氧化能力（Total antioxidant capacity，T-AOC） 和谷胱甘肽过氧化物酶（Glutathione peroxidase，GSH-Px）水平均显著上升（P＜0.05），丙二醛（Malondialdehyde， MDA ）显著下降（P＜0.05），且观察组SOD、T-AOC及GSH-Px水平高于对照组，MDA水平低于对照组（P＜0.05）；两组患者不 良反应发生情况比较无统计学意义（P＞0.05）。结论：复方首乌蒺藜汤联合火针疗法治疗稳定期白癜风患者，能有效提高 临床疗效，促进皮损色素恢复，改善患者免疫状态和氧化应激失衡。
Abstract:
Objective To study the effi cacy of compound Shouwu Jili decoction combined with fi re needle in treating stable vitiligo and its infl uence on the recovery eff ect of skin pigment. Methods 125 patients with stable vitiligo admitted to the hospital from January 2019 to January 2021 were selected and divided into control group (63 cases, fi re needle therapy) and observation group (62 cases, fi re needle+compound Shouwu Jili decoction) according to the random number table method. All patients were given topical application of 0.1% tacrolimus ointment. After 6 months of treatment, the clinical efficacy, and scores of TCM syndromes, skin pigment recovery eff ect, T lymphocyte subsets and oxidative stress indicators before and after treatment were compared between the two groups, and the occurrence of adverse reactions were recorded. Results After treatment, the total eff ective rate in observation group (91.94%) was signifi cantly higher than that in control group (79.37%) (P ＜0.05). After treatment, the scores of TCM symptoms in the two groups were decreased (P＜0.05), and the scores of TCM symptoms in observation group after treatment were lower than those in control group (P＜0.05). After treatment, the white spot area of target skin lesions in the two groups was signifi cantly reduced and the skin pigment score was signifi cantly enhanced (P ＜0.05). And the observation group improved better than the control group (P＜0.05). After treatment, CD3+ , CD4+ and CD4+ /CD8+ in both groups were signifi cantly increased (P ＜0.05) while CD8+ was signifi cantly decreased (P ＜0.05), and the observation group improved better than the control group(P＜0.05). After treatment, the levels of SOD, T-AOC and GSHPx in the two groups were signifi cantly risen (P ＜0.05) while the level of MDA was signifi cantly declined (P ＜0.05), and the indicators in observation group were signifi cantly diff erent from those in control group after treatment (P ＜0.05). There were no statistical diff erences in the occurrence of adverse reactions between the two groups (P ＞0.05). Conclusion Compound Shouwu Jili decoction combined with fi re needle therapy in the treatment of patients with stable vitiligo can eff ectively enhance the clinical effi cacy, promote the recovery of skin pigment, improve the immune status and oxidative stress imbalance.

相似文献/References:

[1]向亚玲,徐 婷. 火针配合穴位埋线治疗囊肿型痤疮疗效观察及对皮肤屏障功能的影响[J].中国美容医学,2020,(4):138.
　XIANG Ya-ling,XU Ting. Effi cacy of Fire Needle Combined with Acupoint Catgut Embedding on Cystic Acneand Its Effects on Skin Barrier Function[J].Medical Aesthetics and Beauty,2020,(10):138.
[2] 吴风琴,王 莉,刘明明,等. 清理术与火针治疗寻常痤疮的疗效及安全性对比观察[J].中国美容医学,2021,(5):115.
　 WU Feng-qin,WANG Li,LIU Ming-ming,et al. Comparison of the Efficacy and Safety of Cleaning and Fire Acupuncture in theTreatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(10):115.
[3]张旭婷,郭筱芳,李东海,等.基于皮肤镜观察火针治疗重度痤疮的疗效[J].中国美容医学,2023,(6):126.
　ZHANG Xuting,GUO Xiaofang,LI Donghai,et al.Observation of Clinical Effect of Fire Acupuncture on Severe Acne based on Dermoscopy[J].Medical Aesthetics and Beauty,2023,(10):126.
[4]陈智斌,陈梦雅,何亚男,等.火针、刺络拔罐联合王不留行籽耳穴贴压治疗面部寻常痤疮[J].中国美容医学,2023,(10):86.[doi:10.15909/j.cnki.cn61-1347/r.005919]
　CHEN Zhibin,CHEN Mengya,HE Yanan,et al.Effi cacy of Fire Needle and Pricking and Cupping Combined with Auricular Plaster Therapy with Cowherb Seed in Patients with Facial Acne Vulgaris[J].Medical Aesthetics and Beauty,2023,(10):86.[doi:10.15909/j.cnki.cn61-1347/r.005919]
[5]方 婧,邓小忠,李桂香,等.火针联合超分子水杨酸治疗玫瑰痤疮的疗效观察[J].中国美容医学,2023,(11):58.[doi:10.15909/j.cnki.cn61-1347/r.006000]
　FANG Jing,DENG Xiaozhong,LI Guixiang,et al.Curative Effect of Fire Needle Combined with Supramolecular Salicylic Acid on Rosacea[J].Medical Aesthetics and Beauty,2023,(10):58.[doi:10.15909/j.cnki.cn61-1347/r.006000]
[6]钟芹锋,周 艳,袁冰峰,等.火针联合耳穴综合治疗面部寻常痤疮的临床疗效及对皮肤屏障功能的影响[J].中国美容医学,2023,(12):78.[doi:10.15909/j.cnki.cn61-1347/r.006034]
　ZHONG Qinfeng,ZHOU Yan,YUAN Bingfeng,et al.Effect of Auricular Points Comprehensive Treatment Combined with Fire Needle on Clinical Effi cacy and Skin Barrier Function in Patients with Facial Acne[J].Medical Aesthetics and Beauty,2023,(10):78.[doi:10.15909/j.cnki.cn61-1347/r.006034]
[7]王 晶,米 兰,罗美俊子,等.火针联合清肺健脾方治疗中重度痤疮的疗效及对血清IGF-1和DHEA水平的影响[J].中国美容医学,2023,(12):82.[doi:10.15909/j.cnki.cn61-1347/r.006066]
　WANG Jing,MI Lan,LUO Meijunzi,et al.Clinical Effi cacy of Fire-needle Therapy Combined with Qingfei Jianpi Decoction on Skin and Its Impact on Serum IGF-1 and DHEA Levels in Patients with Moderate-to severe Acne[J].Medical Aesthetics and Beauty,2023,(10):82.[doi:10.15909/j.cnki.cn61-1347/r.006066]
[8]刘镓毓,倪红辉,蔡 艳,等.火针疗法联合消疮散中药面膜治疗面部寻常痤疮的疗效观察[J].中国美容医学,2024,(2):107.[doi:10.15909/j.cnki.cn61-1347/r.006158]
　LIU Jiayu,NI Honghui,CAI Yan,et al.Observation of Clinical Effi cacy of Fire Needling Therapy Combined with Xiaochuang Powder Mask on Facial Acne[J].Medical Aesthetics and Beauty,2024,(10):107.[doi:10.15909/j.cnki.cn61-1347/r.006158]
[9]万 鹏,祝梦媛,文 莉.复方黄柏液涂剂外敷联合火针治疗寻常痤疮临床疗效观察[J].中国美容医学,2024,(3):88.
　WAN Peng,ZHU Mengyuan,WEN Li.Observation on Clinical Effi cacy of Compound Cortex Phellodendri Fluid Combined with Fire Acupuncture in the Treatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2024,(10):88.
[10]郑晓蝶,赵倩子,汤 慧,等.中医序贯疗法联合异维A酸治疗中重度痤疮的疗效观察[J].中国美容医学,2024,(3):92.
　ZHENG Xiaodie,ZHAO Qianzi TANG Hui,LIANG Yu.Effi cacy of Clinical Effi cacy of Chinese Medicine Sequential Therapy Combined with Isotretinoin in the Treatment of Moderate and Severe Acne[J].Medical Aesthetics and Beauty,2024,(10):92.

更新日期/Last Update: 2023-11-01