[1] 殷旭峰综述,布文博 陈 旭 周炳荣审校. 瘢痕疙瘩相关干细胞研究进展[J].中国美容医学,2021,(3):186-189.
　 YIN Xu-feng,BU Wen-bo,CHEN Xu,et al. Research Progress of Keloid-related Stem Cells[J].Medical Aesthetics and Beauty,2021,(3):186-189.
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 瘢痕疙瘩相关干细胞研究进展
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年3期
页码:
186-189
栏目:
出版日期:
2021-03-10

文章信息/Info

Title:
 Research Progress of Keloid-related Stem Cells
文章编号:
1008-6455(2021)03-0186-04
作者:
 殷旭峰1综述; 布文博2 陈 旭2 周炳荣1审校
Author(s):
 YIN Xu-feng1; BU Wen-bo2; CHEN Xu2; ZHOU Bing-rong1
关键词:
 [关键词]瘢痕疙瘩; 干细胞; 微环境; 表型标志物; 生物学特性
Keywords:
 Key words:keloid; stem cells; niche; phenotypic markers; biological characteristics
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]瘢痕疙瘩（Keloid）是一种发病机制不明的皮肤纤维增生性疾病，伴有极高的复发率。近年来，通过对干细胞特征表
面抗原鉴定，发现瘢痕疙瘩中可能存在间充质干细胞（Mesenchymal-like stem cell）和造血干细胞（Hematopoietic stem
cells）。后续的研究进一步发现各种刺激因素作用下，例如：炎症反应、外界张力作用下，发生上皮-间充质改变，这就影
响了正常的干细胞所处的一个由间充质细胞、细胞外基质、血管和炎性细胞等共同构成的微环境(Niche)，从而形成一种独
特的病理微环境来促进瘢痕疙瘩干细胞的增殖。外源性干细胞用于瘢痕疙瘩的临床治疗尚处于实验阶段，对瘢痕疙瘩相关干
细胞的深入研究，将为探索瘢痕疙瘩发病机制和临床治疗提供一个新方向。

Abstract:
Abstract: Keloid is a skin fibroproliferative disease of unknown pathogenesis, with an extremely high recurrence rate. In recent
years, with antigen identification of surface of stem cell features, mesenchymal-like stem cells and hematopoietic stem cells
that may be present in keloid have been discovered. Subsequent research further found: under the effects of various stimulating
factors, for example the effects of inflammatory response and external tension, epithelial-mesenchymal will change. This effects
the niche in which the normal stem cells are located, a niche composed of mesenchymal-like cells, extracellular matrix, blood
vessels, inflammatory cells, etc.Thus forming a unique pathological niche to promote the proliferation of keloid stem cells. The
clinical treatment of exogenous stem cells for keloid is still in experimental stage. Deep research on keloid-related stem cells
will provide a new direction for exploring the pathogenesis and clinical treatment of keloid.

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更新日期/Last Update: 2021-04-13