[1]滕 艳,聂 瑾,朱蓓蓓,等. 活性溶菌酶试验对痤疮发病机制的作用探讨[J].中国美容医学,2018,(03):66-68.
　TENG Yan,NIE Jin,ZHU Bei-bei,et al. The Active Lysozyme Test to Investigate the Pathogenesis of Acne[J].Medical Aesthetics and Beauty,2018,(03):66-68.
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 活性溶菌酶试验对痤疮发病机制的作用探讨()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年03期
页码:
66-68
栏目:
出版日期:
2018-04-10

文章信息/Info

Title:
 The Active Lysozyme Test to Investigate the Pathogenesis of Acne
文章编号:
1008-6455（2018）03-0066-03
作者:
 滕 艳; 聂 瑾; 朱蓓蓓; 宦 静; 杨雪源; 刘 毅; 侯 伟
Author(s):
 TENG Yan; NIE Jin; ZHU Bei-bei; HUAN Jing; YANG Xue-yuan; LIU Yi; HOU Wei
关键词:
 ; [关键词]痤疮; 活性溶菌酶; 痤疮丙酸杆菌; 微生物; 发病机制
Keywords:
 ; Key words: acne;  active lysozyme;  propionibacterium acnes;  microorganisms; pathogenesis
分类号:
R758.73+3
文献标志码:
A
摘要:

[摘要]目的：探讨痤疮皮损分离的常见微生物中，非痤疮丙酸杆菌在痤疮发生中的作用。方法：评估记录及对比分析33例
痤疮患者使用活性溶菌酶前（基线）、使用后第2周、第4周面部粉刺及炎性皮损的数量和严重程度。结果：基线、治疗后第2
周、第4周非炎性皮损（粉刺）数量分别为（13.64±5.90）处、（13.64±5.92）处、（13.27±6.27）处，试验前、后非炎性皮
损（粉刺）数量变化无统计学意义（P ＞0.05）；基线、治疗后第2周、第4周炎性皮损（丘疹、脓疱）数量分别为9.48±5.14、
7.45±4.27、6.06±4.50，试验前、后炎性皮损数量变化有统计学意义（P＜0.01）；18例受试者使用活性溶菌酶后炎性皮损减
少30%以上，有效率达54.55%。结论：除痤疮丙酸杆菌外，其它微生物在痤疮发病机制中也可能起着一定作用。


Abstract:
Abstract: Objective To investigate the role of non-P.acnes in the development of acne in common microorganisms isolated
from acne lesions. Methods Records and comparative Analysis of the number and severity of facial comedo and inflammatory
lesions in 33 subjects with acne prior to active lysozyme use (baseline) and at week 2, week 4 post-use. Results At baseline,the
second and fourth week after the test the number of non-inflammatory lesions (comedo) were 13.64±5.90,13.64±5.92 and
13.27±6.27.There was no significant difference in the number of non-inflammatory lesions(comedo) before and after the
treatment(P ＞0.05). At baseline,the second and fourth week after the test the number of inflammatory lesions (papules and
pustules) were 9.48±5.14,7.45±4.27 and 6.06±4.50.The numbers of inflammatory lesions before and after the test had statistical
significance(P ＜0.01).Eighteen subjects reduced the inflammatory lesions by more than 30% and the effective rate reached
54.55%. Conclusion Other microorganisms besides P.acnes may also play a role in the pathogenesis of acne.

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更新日期/Last Update: 2018-06-07