[1]刘 波,胡友红. 痤疮患者外周血TLR-2、IL-4、IL-8、TNF-α表达水平与痤疮严重程度相关性研究[J].中国美容医学,2018,(03):111-113.
　LIU Bo,HU You-hong. The Correlation Study between the Expression of TLR-2, IL-4, IL-8, TNF-α and the Severity of Acne in Acne Patients[J].Medical Aesthetics and Beauty,2018,(03):111-113.
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 痤疮患者外周血TLR-2、IL-4、IL-8、TNF-α表达水平与痤疮严重程度相关性研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年03期
页码:
111-113
栏目:
出版日期:
2018-04-10

文章信息/Info

Title:
 The Correlation Study between the Expression of TLR-2, IL-4, IL-8, TNF-α and the Severity of Acne in Acne Patients
文章编号:
1008-6455（2018）03-0111-03
作者:
 刘 波1; 2; 胡友红2
Author(s):
 LIU Bo1; 2; HU You-hong2
关键词:
 ; [关键词]痤疮; TOLL样受体; 白介素-4; 白介素-8; 肿瘤坏死因子-α
Keywords:
 ; Key words: acne vulgaris;  Toll-like receptors;  IL-4;  IL-8;  Tumor necrosis factor-α
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的：检测痤疮患者外周血TLR-2、IL-4、IL-8、TNF-α的水平，并分析这些因素与痤疮严重程度的相关性。方法：
收集本院皮肤科门诊收治的寻常性痤疮患者90例，轻、中、重度患者各30例，另选择30例健康者作为对照组。流式细胞仪检
测外周血CD14+单核细胞TLR-2表达，双抗体夹心酶联免疫吸附法(ELISA)检测血清IL-4、IL-8、TNF-α水平。结果：三组痤
疮患者TLR-2、IL-4、IL-8及TNF-α表达均高于对照组，差异有统计学意义（P＜0.05），且均与痤疮严重程度呈正相关（P
＜0.05）。结论：痤疮患者外周血TLR-2、IL-4、IL-8、TNF-α的检测可指导痤疮严重程度的客观评价和临床治疗。

Abstract:

Abstract: Objective To explore the role of TLR-2, IL-4, IL-8 and TNF-α in the pathogenesis of acne vulgaris, and analyze the
correlation between these factors and the severity of the clinical manifestations of acne. Methods Venous blood was collected
from 30 human controls and 90 patients with acne vulgaris, the patients were divided into three groups, mild, moderate and severe
group. TLR-2 expression of CD14+ monocyte in peripheral blood of flow cytometry and the level of IL-4, IL-8 and TNF-α in
serum by double antibody enzyme linked immunosorbent assay (ELISA). Results The expression of TLR-2, IL-4, IL-8 and
TNF-α in three groups of acne patients were all higher than those of the control group, and the difference were statistically
significant(P ＜0.05). And which was positively correlated with the severity of acne(P ＜0.05). Conclusion The detection
of TLR-2, IL-4, IL-8 and TNF-α in the peripheral blood of acne patients can guide the objective evaluation and clinical
treatment of the severity of acne.

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更新日期/Last Update: 2018-06-07