[1]李 伶,郭中华. 调Q脉冲激光联合甲硝唑凝胶和多西环素治疗轻中度玫瑰痤疮疗效研究[J].中国美容医学,2019,(09):18-20.
　LI Ling,GUO Zhong-hua. Curative Effect of Q-switched Pulsed Laser Radiation Combined with MetronidazoleGel and Doxycycline in the Treatment of Mild to Moderate Rosacea[J].Medical Aesthetics and Beauty,2019,(09):18-20.
点击复制

 调Q脉冲激光联合甲硝唑凝胶和多西环素治疗轻中度玫瑰痤疮疗效研究
()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年09期
页码:
18-20
栏目:
出版日期:
2019-09-05

文章信息/Info

Title:
 Curative Effect of Q-switched Pulsed Laser Radiation Combined with Metronidazole
Gel and Doxycycline in the Treatment of Mild to Moderate Rosacea
文章编号:
1008-6455（2019）09-0018-03
作者:
李 伶; 郭中华
Author(s):
LI Ling; GUO Zhong-hua
关键词:
[关键词]玫瑰痤疮; 调Q脉冲激光; 甲硝唑; 多西环素; 红斑; 疗效
Keywords:
Key words: rosacea;  Q-switched pulsed laser radiation;  metronidazole;  doxycycline;  erythema;  therapeutic effect
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的：探讨调Q脉冲激光联合甲硝唑凝胶与多西环素药物治疗玫瑰痤疮的疗效和安全性。方法：选取2015年7月-2018
年9月笔者医院门诊收治的轻、中度玫瑰痤疮患者80例，采用随机数字法分为对照组（38例）和观察组（42例），其中观察
组采用调Q脉冲激光联合甲硝唑凝胶和多西环素治疗，对照组采用甲硝唑凝胶外用+多西环素口服治疗。观察两组患者治疗6
周后临床疗效与总体评分(investigator’s global assessment，IGA)、炎性丘疹数以及治疗前后症状积分（红斑、丘疹脓
疱、瘙痒）。结果：治疗6周，观察组临床疗效显著优于对照组，组间差异具有统计学意义（P ＜0.05）；治疗6周后，两组
患者IGA评分明显下降，且观察组明显低于对照组，差异具有统计学意义（P ＜0.05）；两组患者治疗前红斑、丘疹脓疱、
瘙痒等症状积分无统计学差异（P ＞0.05），治疗后两组患者红斑、丘疹脓疱、瘙痒等症状积分明显转好，且观察组临床症
状积分低于对照组，差异有统计学意义（P ＜0.05）。结论：采用调Q脉冲激光联合药物治疗玫瑰痤疮，患者临床症状明显改
善，可达到理想的治疗效果。

Abstract:
Abstract: Objective To evaluate the efficacy and safety of Q-switched pulsed laser radiation combined with metronidazole
gel and doxycycline in the treatment of rosacea. Methods 80 patients with mild and moderate rosacea admitted in our
hospital from July 2015 to September 2018 were selected as the subjects and divided into the control group (38 cases) and
the observation group (42 cases) by random number method. The observation group was treated with Q-switched pulsed
laser radiation combined with metronidazole gel and doxycycline, the control group was treated with metronidazole gel for
external use + doxycycline for oral therapy. The clinical efficacy, the investigator’s global assessment (IGA), the number of
inflammatory papules and the score of symptoms (erythema, papule pustules, pruritus) before and after treatment were observed
at six weeks after treatment. Results After 6 weeks of treatment, the clinical efficacy of the observation group was significantly
better than that of the control group, and the difference between the two groups was statistically significant (P ＜0.05); after
6 weeks of treatment, the IGA scores of the two groups were significantly decreased, and the IGA score of the observation
group was significantly lower than that of the observation group, and the difference between the two groups was statistically
significant (P ＜0.05); there was no significant difference in the scores of erythema, papule pustule, pruritus and other symptoms
before treatment between the two groups (P ＞0.05), after treatment, the scores of erythema, papule pustule, pruritus and other
symptoms of the two groups were significantly improved, and the scores of clinical symptoms of the observation group were
lower than those of the control group, and there was a significant difference between the two groups (P ＜0.05). Conclusion
The use of Q-switched pulsed laser radiation combined with drugs on rosacea can significantly improve the clinical symptoms
of patients, and achieve the desired therapeutic effect.

相似文献/References:

[1]陈劲奕,刘海霞,杨 涛,等. 盐酸米诺环素联合复方甘草酸苷序贯强脉冲光治疗Ⅰ型玫瑰痤疮疗效观察[J].中国美容医学,2018,(04):46.
　CHEN Jin-yi,LIU Hai-xia,YANG Tao,et al. Efficacy of Minocycline Hydrochloride Combined with Compound Glycyrrhizin in Sequential Pulsed Light Therapy for Acne Rosacea[J].Medical Aesthetics and Beauty,2018,(09):46.
[2]焦 烨,闵仲生. 基于聚类分析探讨玫瑰痤疮的中医证型分布[J].中国美容医学,2018,(12):131.
　JIAO Ye,MIN Zhong-Sheng. The Research of the Distribution of TCM Syndromes of Rosacea Based on Cluster Analysis[J].Medical Aesthetics and Beauty,2018,(09):131.
[3]陈永国,崔 静,杨 慧. 5-氨基酮戊酸光动力疗法联合常规方法治疗玫瑰痤疮疗效观察[J].中国美容医学,2019,(02):66.
　CHEN Yong-guo,CUI Jing,YANG Hui. Effect of Aminolevulinic Acid Photodynamic Therapy Combined with RoutineTreatment on Rosacea[J].Medical Aesthetics and Beauty,2019,(09):66.
[4]陈永国,崔 静,杨 慧. 5-氨基酮戊酸光动力疗法联合常规方法治疗玫瑰痤疮疗效观察[J].中国美容医学,2019,(02):66.
　CHEN Yong-guo,CUI Jing,YANG Hui. Effect of Aminolevulinic Acid Photodynamic Therapy Combined with RoutineTreatment on Rosacea[J].Medical Aesthetics and Beauty,2019,(09):66.
[5]张嘉文 刘子菁 王小燕 Juliandri刘韵祎 马仁燕 综述,许 阳 审校. 玫瑰痤疮的光电治疗研究进展[J].中国美容医学,2019,(05):159.
　ZHANG Jia-wen,LIU Zi-jing,WANG Xiao-yan,et al. Research Progress of Photoelectric for Rosacea[J].Medical Aesthetics and Beauty,2019,(09):159.
[6]何淑娟,夏 君,胡光蕾,等. 超分子水杨酸联合米诺环素治疗玫瑰痤疮临床疗效分析[J].中国美容医学,2019,(07):14.
　HE Shu-juan,XIA Jun,HU Guang-lei,et al. Clinical Efficacy of Supramolecular Salicylic Acid Combined with Minocycline in the Treatment of Rosacea[J].Medical Aesthetics and Beauty,2019,(09):14.
[7]梁 博,李国东,何明璇,等. 玫瑰痤疮与肠道菌群紊乱的相关性研究[J].中国美容医学,2019,(07):48.
　LIANG Bo,LI Guo-dong,HE Ming-xuan,et al. Clinical Study on the Correlation between Roseacne and Intestinal Flora Disorder[J].Medical Aesthetics and Beauty,2019,(09):48.
[8]王琳洁 综述,康晓静 审校. 玫瑰痤疮各亚型的特征及临床联系的研究进展[J].中国美容医学,2020,(4):60.
　WANG Lin-jie,KANG Xiao-jing. Advancement on the Characteristics and Clinical Relationship of Various Subtypes of Rosacea[J].Medical Aesthetics and Beauty,2020,(09):60.
[9]宋 晗,田庆均. 凉血四物汤联合强脉冲光治疗玫瑰痤疮临床效果评价[J].中国美容医学,2020,(4):141.
　SONG Han,TIAN Qing-jun. Clinical Evaluation of Blood-cooling Four Agents Decoction Combined with IntensePulsed Light in the Treatment of Rose Acne[J].Medical Aesthetics and Beauty,2020,(09):141.
[10] 方 慧,陈 滨. 调Q脉冲激光和两种波段强脉冲光治疗面部痤疮后红斑及色素沉着疗效比较[J].中国美容医学,2021,(5):90.
　 FANG Hui,CHEN Bin. Curative Effect of Q-switched Pulse Laser and Intensive Pulsed Light on Facial AcneErythema ond Pigmentation[J].Medical Aesthetics and Beauty,2021,(09):90.

更新日期/Last Update: 2019-09-24