[1] 刘 可,李静波,高以红. 308nm准分子光联合0.1%他克莫司软膏治疗稳定期白癜风的疗效及安全性分析[J].中国美容医学,2020,(7):39-42.
　 LIU Ke,LI Jing-bo,GAO Yi-hong. Analysis of Effi cacy and Safety of 308nm Excimer Light Combined with 0.1%Tacrolimus Ointment in the Treatment of Stable Vitiligo[J].Medical Aesthetics and Beauty,2020,(7):39-42.
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 308nm准分子光联合0.1%他克莫司软膏治疗稳定期白癜风的疗效及安全性分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年7期
页码:
39-42
栏目:
出版日期:
2020-07-10

文章信息/Info

Title:
 Analysis of Effi cacy and Safety of 308nm Excimer Light Combined with 0.1%
Tacrolimus Ointment in the Treatment of Stable Vitiligo
文章编号:
1008-6455(2020)07-0039-04
作者:
 刘 可; 李静波; 高以红
Author(s):
 LIU Ke; LI Jing-bo; GAO Yi-hong
关键词:
 [关键词]308nm准分子光; 0.1%他克莫司软膏; 稳定期白癜风; 疗效
Keywords:
 Key words: 308 excimer light;  0.1% tacrolimus ointment;  stable vitiligo;  effi cacy
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：分析308nm准分子光联合0.1%他克莫司软膏治疗稳定期白癜风的疗效及安全性。方法：回顾性分析笔者医院收
治的121例稳定期白癜风患者，按治疗方式不同分成两组。单一组：50例，予以308nm准分子光治疗；联合组：71例，予以
308nm准分子光联合0.1%他克莫司软膏治疗，治疗3个月，比较两组临床疗效、皮肤CT情况、Foxp3 mRNA表达水平以及细胞因
子水平，并观察其安全性。结果：治疗3个月，联合组总治愈率为76.06%，显著高于单一组的56.00%(P ＜0.05)；联合组部
分黑素细胞活跃53例（74.65%），单一组部分黑素细胞活跃16例（32.00%），联合组发生率显著高于单一组(P ＜0.05)；两组
Foxp3 mRNA表达水平显著上调(P ＜0.05)，联合组上调幅度大于单一组(P ＜0.05)；两组TNF-α、INF-γ显著降低(P ＜0.05)，
SCF、bFGF显著升高(P ＜0.05)，联合组变化幅度大于单一组(P ＜0.05)；两组血常规、肝肾功能无明显异常，治疗期间不良
反应发生率无显著性差异(P ＞0.05)。结论：308nm准分子光联合0.1%他克莫司软膏治疗稳定期白癜风临床疗效明确，可显著
改善患者皮损症状，上调Foxp3 mRNA表达，调节细胞因子水平，安全有效。

Abstract:
Abstract: Objective To analyze the effi cacy and safety of 308 excimer light combined with 0.1% tacrolimus ointment in the
treatment of stable vitiligo. Methods A retrospective analysis was performed on 121 patients with stable vitiligo in our hospital,
and they were divided into two groups according to different treatment methods. 50 patients in single group were given 308
excimer light therapy while 71 patients in combined group were given 308 excimer light combined with 0.1% tacrolimus
ointment, and they were treated for 3 months. The clinical effi cacy, skin CT, expression level of Foxp3 mRNA and levels of
cytokines were compared between the two groups, and the safety was observed. Results After 3 months of treatment, the total
cure rate in combined group was signifi cantly higher than that in single group (76.06% vs 56.00%) (P ＜0.05). There were 53
cases (74.65%) of some active melanocytes in combined group and 16 cases (32.00%) in single group, and the incidence rate of
some active melanocytes in combined group was signifi cantly higher than that in single group (P ＜0.05).The expression level of
Foxp3 mRNA was signifi cantly up-regulated in the two groups (P ＜0.05), and the up-regulation in combined group was greater
than that in single group (P ＜0.05).The TNF-α and INF-γ were signifi cantly decreased in the two groups (P ＜0.05) while the
SCF and bFGF were signifi cantly increased (P ＜0.05), and the changes in combined group were larger than those in single
group (P ＜0.05). There were no obvious abnormalities in the blood routine and liver and kidney function in the two groups,
and there was no signifi cant difference in the incidence rate of adverse reactions during treatment (P ＞0.05). Conclusion 308
excimer light combined with 0.1% tacrolimus ointment has exact clinical effi cacy in the treatment of stable vitiligo, and it can
signifi cantly improve the symptoms of skin lesions, up-regulate Foxp3 mRNA expression, and regulate cytokines levels, and it
is safe and effective.

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[2]段鳕芸,张忠奎,周 舟,等.强脉冲光联合0.1%他克莫司软膏治疗红斑毛细血管扩张型玫瑰痤疮疗效观察[J].中国美容医学,2023,(1):92.
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更新日期/Last Update: 2020-07-22