[1] 杨正祥,李 航,沈庆冉. 盐酸米诺环素软膏联合替硝唑对慢性根尖周炎患者牙齿颜色和菌斑及疼痛的影响[J].中国美容医学,2020,(9):141-144.
　 YANG Zheng-xiang,LI Hang,SHEN Qing-ran. Effects of Minocycline Hydrochloride Ointment Combined with Tinidazole on ToothColor,Plaque and Pain in Patients with Chronic Apical Periodontitis[J].Medical Aesthetics and Beauty,2020,(9):141-144.
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 盐酸米诺环素软膏联合替硝唑对慢性根尖周炎患者牙齿颜色和菌斑及疼痛的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年9期
页码:
141-144
栏目:
出版日期:
2020-09-10

文章信息/Info

Title:
 Effects of Minocycline Hydrochloride Ointment Combined with Tinidazole on Tooth
Color,Plaque and Pain in Patients with Chronic Apical Periodontitis
文章编号:
1008-6455（2020）09-0141-04
作者:
 杨正祥1; 李 航2; 沈庆冉1
Author(s):
 YANG Zheng-xiang1; LI Hang2; SHEN Qing-ran1
关键词:
 [关键词]慢性根尖周炎; 根管治疗; 替硝唑片; 盐酸米诺环素软膏; 牙周微生态环境; 疼痛程度
Keywords:
 Key words:chronic periapical periodontitis; root canal therapy;  tinidazole tablets; minocycline hydrochlorideointment; periodontal microecological environment;  the degree of pain
分类号:
R781.4+2
文献标志码:
A
摘要:
[摘要]目的：探讨盐酸米诺环素软膏联合替硝唑治疗对慢性根尖周炎患者牙齿颜色、菌斑及疼痛的影响。方法：选取2018年
1月-2020年1月于笔者医院口腔科就诊的127例慢性根尖周炎患者，以随机数字表法分为常规组（64例）和盐酸米诺环素组
（63例）。两组均接受基础治疗及根管治疗，常规组主要以氢氧化钙进行根管消毒，盐酸米诺环素组主要以盐酸米诺环素软
膏进行根管消毒，两组根管治疗后均予以替硝唑片口服，共治疗4周。观察两组治疗4周后的疗效、疼痛程度，治疗前、
治疗4周后的牙周微生态环境、炎症因子水平及治疗期间不良反应发生情况。结果：治疗4周后，盐酸米诺环素组总有效
率92.06%，高于常规组的78.13%（P ＜0.05）；盐酸米诺环素组Ⅰ级疼痛例数较常规组多，NRS疼痛评分则低于常规组
（P ＜0.05）。治疗4周后，两组GI、PLI、MD、PPD均低于治疗前，且盐酸米诺环素组低于常规组（P ＜0.05）；两组牙龈沟
液中IL-6、TNF-α、IL-1β水平均低于治疗前，且盐酸米诺环素组低于常规组（P ＜0.05）。治疗期间，盐酸米诺环素组不
良反应发生率为7.93%，与常规组的9.38%比较无统计学差异（P ＞0.05）。结论：盐酸米诺环素软膏联合替硝唑可抑制慢性
根尖周炎患者牙周炎症、改善牙周微生态环境，进而有效改善牙齿颜色、菌斑及疼痛程度，临床疗效显著，且联合用药不增
加不良反应发生率，值得临床推广应用。

Abstract:
Abstract:Objective To investigate the effect of minocycline hydrochloride ointment combined with tinidazole on tooth color,
plaque and pain in patients with chronic periapical periodontitis. Methods 127 patients with chronic periapical periodontitis who
visited our hospital from January 2018 to January 2020 were selected and randomly divided into the routine group (64 cases)
and the minocycline hydrochloride group (63 cases). Both groups received basic treatment and root canal treatment. The routine
group was mainly treated with calcium hydroxide for root canal disinfection. The minocycline hydrochloride group was mainly
treated with minocycline hydrochloride ointment for root canal disinfection. Tinidazole tablets were taken orally for 4 weeks
after root canal treatment in both groups. The curative effect and pain degree of the two groups after 4 weeks of treatment,
periodontal microecological environment, inflammatory factor level and adverse reactions during treatment before and after 4
weeks of treatment were observed. Results After 4 weeks of treatment, the total effective rate in the minocycline hydrochloride
group was 92.06%, which was higher than 78.13% in the routine group (P ＜0.05). The number of cases with grade I pain of
the minocycline hydrochloride group was higher than that of the routine group, and the NRS pain score is lower than that of the
routine group (P ＜0.05). After 4 weeks of treatment, GI, PLI, MD, PPD of the two groups were lower than before treatment,
and the minocycline hydrochloride group was lower than the routine group (P ＜0.05). The levels of IL-6, TNF-α and IL-1β in
gingival crevicular fluid of the two groups were lower than those before treatment, and the minocycline hydrochloride group
were lower than the routine group (P ＜0.05). During the treatment, the incidence of adverse reactions in the minocycline
hydrochloride group was 7.93%, and there was no statistical difference between the minocycline hydrochloride group and the
routine group (9.38%)(P ＞0.05). Conclusion Minocycline hydrochloride ointment combined with tinidazole can effectively
inhibit periodontitis in patients with chronic periapical periodontitis, improve periodontal microecological environment, and
further effectively improve tooth color, plaque and pain degree. The clinical effect is significant, and the combination does not
increase the incidence of adverse reactions, which is worthy of promotion.

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更新日期/Last Update: 2020-09-28