[1] 杨雪松,付 彧,毛慧玲,等. 稳定期白癜风患者组织液sICAM-1水平与临床特征的相关性分析[J].中国美容医学,2021,(6):83-86.
　 YANG Xue-song,FU Yu,MAO Hui-ling,et al. Correlation Analysis between the sICAM-1 in the Skin Tissue Fluid with Stable Vitiligoand Clinical Characteristics[J].Medical Aesthetics and Beauty,2021,(6):83-86.
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 稳定期白癜风患者组织液sICAM-1水平与临床特征的相关性分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年6期
页码:
83-86
栏目:
出版日期:
2021-06-10

文章信息/Info

Title:
 Correlation Analysis between the sICAM-1 in the Skin Tissue Fluid with Stable Vitiligo
and Clinical Characteristics
文章编号:
1008-6455(2021)06-0083-03
作者:
 杨雪松1; 付 彧2; 毛慧玲3; 颜令义1; 房庆华1; 哈 达1 ; 吕晓红1 ; 刘 灵1 ; 陶 宇1
Author(s):
 YANG Xue-song1; FU Yu2; MAO Hui-ling3; YAN Ling-yi1; FANG Qing-hua1; HA Da1; LV Xiao-hong1; LIULing1; TAO Yu1
关键词:
 [关键词]白癜风; 可溶性细胞间黏附分子-1; 病程; 皮损面积; 年龄
Keywords:
 Key words: vitiligo;  sICAM-1;  course of disease; lesion area; age
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：探究稳定期白癜风患者皮肤组织液sICAM-1水平的表达变化及与临床特征的关联性。方法：选择30例笔者医院
收治确诊的稳定期白癜风患者为研究对象，其中寻常型20例，节段型10例，采用酶联免疫吸附法（ELISA）对白斑处和非白
斑处皮肤组织液中的sICAM-1水平进行对比分析，并由专人记录患者的临床特征。结果：对稳定期白癜风患者的皮肤组织液
sICAM-1水平进行检测：①寻常型白斑处sICAM-1水平明显高于非白斑处（P ＜0.05），且高于节段型（P ＜0.05）；②白斑处
sICAM-1水平与病程呈负相关性（P ＜0.05），寻常型和节段型白斑处sICAM-1水平与病程均呈负相关性（P ＜0.05）；③白斑
处sICAM-1水平与皮损面积呈正相关性（P ＜0.05）；④节段型白斑处sICAM-1水平与年龄呈负相关性（P ＜0.05）；⑤寻常型
皮损面积大于节段型（P ＜0.05）。结论：稳定期白癜风患者白斑处皮肤组织液中sICAM-1水平表达异常，且与患者病程和皮
损面积有关。

Abstract:
Abstract: Objective The correlation analysis between the sICAM-1 in the skin tissue fluid with stable vitiligo and clinical
characteristics were investigated. Methods Selected 30 patients with stable vitiligo, including 20 patients with vitiligo vulgaris
and 10 patients with segmental vitiligo.The levels of sICAM-1 in the skin tissue fluid at white spots and non-white spots were
compared and analyzed by enzyme-linked immunosorbent assay (ELISA).The patient’s clinical characteristics were recorded
by the same person. Results The levels of sICAM-1 in the skin tissue fluid with stable vitiligo were detected: ①The levels of
sICAM-1 in the white spots with vitiligo vulgaris was significantly higher than that in the non-white spots (P ＜0.05), and higher
than that with segmental vitiligo (P ＜0.05). ②There was a negative correlation between the levels of sICAM-1 and course
of disease in white spots (P ＜0.05).There was a negative correlation between the levels of sICAM-1 and course of disease in
white spots with vitiligo vulgaris(P ＜0.05). There was a negative correlation between the levels of sICAM-1 and course of
disease in white spots with segmental vitiligo(P ＜0.05).③There was a positive correlation between the levels of sICAM-1 and
lesion area in white spots(P ＜0.05). ④There was a negative correlation between the levels of sICAM-1 and age in white spots
with segmental vitiligo(P ＜0.05). ⑤The lesion area of vitiligo vulgaris was larger than that of segmental vitiligo (P ＜0.05).
Conclusion The expression of sICAM-1 in the skin tissue fluid with stable vitiligo was abnormal, which was related to the
course of disease and lesion area.

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更新日期/Last Update: 2021-07-13