[1]王嘉厅 综述,吴信峰 审校.先天性巨大黑素痣的发病机制及其靶向治疗的研究进展[J].中国美容医学,2022,(11):189-193.
　WANG Jiating,WU Xinfeng.Research Progress on Pathogenesis and Targeted Therapy of Giant Congenital Melanocytic Nevs[J].Medical Aesthetics and Beauty,2022,(11):189-193.
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先天性巨大黑素痣的发病机制及其靶向治疗的研究进展()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年11期
页码:
189-193
栏目:
出版日期:
2022-11-10

文章信息/Info

Title:
Research Progress on Pathogenesis and Targeted Therapy of Giant Congenital Melanocytic Nevs
文章编号:
1008-6455(2022)11-0189-04
作者:
王嘉厅 综述; 吴信峰 审校
 (中国医学科学院皮肤病医院整形美容外科 江苏 南京 210042)
Author(s):
WANG Jiating; WU Xinfeng
(Department of Plastic Surgery, Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042, Jiangsu, China)
关键词:
先天性巨大黑素痣; 发病机制; 信号通路; 靶向治疗
Keywords:
giant congenital melanocytic nevus;  pathogenesis;  signaling pathway;  targeted therapy
分类号:
R739.5
文献标志码:
A
摘要:
先天性巨大黑素痣（Giant congenital melanocytic nevus,GCMN）是一种神经嵴起源的皮肤黑素细胞良性增生，严 重影响患者的身心健康。目前，对于GCMN的病因及发病机制尚无充分的认识，对GCMN的治疗亦无满意的手段。本文从分子生 物学的角度，总结近年来相关文献，发现多种基因突变及明星信号通路的激活对GCMN的形成和发展有着极其重要的作用。现 拟对GCMN的发病机制及其靶向治疗的研究进展进行综述，来探讨靶向治疗在GCMN治疗中的作用。
Abstract:
Giant congenital melanocytic nevus (GCMN) is a benign proliferation of skin melanocytes derived from neural crest, which seriously aff ects the physical and mental health of patients.At present, there is no suffi cient understanding of the etiology and pathogenesis of GCMN, and there is no satisfactory treatment for GCMN.From the perspective of molecular biology, this paper summarizes relevant literatures in recent years and fi nds that multiple gene mutations and activation of star signaling pathway play an extremely important role in the formation and development of GCMN.This paper reviews the pathogenesis of GCMN and the research progress of targeted therapy to discuss the role of targeted therapy in the treatment of GCMN.

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更新日期/Last Update: 2022-11-24