[1]彭 英,张 逸,王 磊.超脉冲点阵CO2激光联合湿润烧伤膏外用在面颈部烧伤后瘢痕修复中的应用[J].中国美容医学,2022,(7):31-35.
　PENG Ying,ZHANG Yi,WANG Lei.Application of Ultra-pulsed Fractional CO2 Laser Combined with MEBO External Use in the Repair of Scar after Faciocervical Burns[J].Medical Aesthetics and Beauty,2022,(7):31-35.
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超脉冲点阵CO2激光联合湿润烧伤膏外用在面颈部烧伤后瘢痕修复中的应用()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年7期
页码:
31-35
栏目:
出版日期:
2022-07-10

文章信息/Info

Title:
Application of Ultra-pulsed Fractional CO2 Laser Combined with MEBO External Use in the Repair of Scar after Faciocervical Burns
文章编号:
1008-6455（2022）07-0031-04
作者:
彭 英; 张 逸; 王 磊
(南通大学附属医院烧伤整形科 江苏 南通 226001)
Author(s):
PENG Ying; ZHANG Yi; WANG Lei
(Department of Burn and Plastic Surgery,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu,China)
关键词:
湿润烧伤膏; 超脉冲点阵CO2激光; 瘢痕; 烧伤; 面颈部; 美学效果
Keywords:
moist exposed burn ointment (MEBO);  ultra-pulsed fractional CO2 laser;  scar;  burn;  faciocervical;  aesthetic effect
分类号:
R619+ .6
文献标志码:
A
摘要:
目的：探讨超脉冲点阵CO2激光联合湿润烧伤膏（Moist exposed burn ointment，MEBO）外用在面颈部烧伤后瘢痕修复中的应用效果。方法：选取2019年1月-2021年1月在笔者医院确诊的82例面颈部烧伤后瘢痕患者为研究对象，采用简单随机分组将患者分为观察组和对照组，每组41例。对照组超脉冲点阵CO2激光治疗后应用红霉素眼膏涂抹，观察组激光治疗后应用MEBO。观察并记录疼痛时间、脱痂时间和创面愈合时间；采用温哥华瘢痕量表（Vancouver scar scale，VSS）评估治疗前和治疗3个月后瘢痕情况；采用视觉模拟评分法（Visual analogue scale，VAS）评估激光治疗后1 h和24 h的疼痛程度；使用皮肤病生活质量指数量表（Dermatology life quality index，DLQI）评估患者生活质量；免疫组化法检测角蛋白19（CK19）和核蛋白p63阳性表达；记录两组患者治疗期间不良反应发生情况。结果：观察组治疗总有效率为95.12%，高于对照组的80.49%，差异有统计学意义（P＜0.05）。观察组疼痛时间、脱痂时间、创面愈合时间、VSS评分、VAS评分和DLQI评分均明显低于对照组，差异有统计学意义（P＜0.05）。治疗3 d后，观察组CK19和p63强阳性率高于对照组，但组间比较差异无统计学意义（P＞0.05）；治疗7 d后，观察组CK19和p63强阳性率显著高于对照组，差异有统计学意义（P＜0.05）。治疗3个月后，观察组不良反应发生率为17.07%，低于对照组的31.71%，但组间比较差异无统计学意义（P＞0.05）。结论： 超脉冲点阵CO2激光联合MEBO外用治疗面颈部烧伤后瘢痕美学效果显著，能够加速创面愈合。
Abstract:
Objective To explore the application of ultra-pulsed fractional CO 2 laser combined with MEBO external use in the repair of scar after faciocervical burns. Methods A total of 82 patients with scars after faciocervical burns confirmed in the hospital were enrolled between January 2019 and January 2021. According to simple random grouping method, they?span style="color: rgb(35, 31, 32); font-family: "Times New Roman"; font-size: 9.5pt;">were divided into the observation group and the control group, 41 cases in each group. In the control group, erythromycin eye?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">ointment was applied after ultra-pulsed fractional CO2 laser treatment, while the observation group was treated with MEBO?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">after ultra-pulsed fractional CO2 laser treatment. The pain time, decrustation time and wound healing time were observed and?span style="color: rgb(35, 31, 32); font-family: "Times New Roman"; font-size: 9.5pt;">recorded. The scar conditions before treatment and after 3 months of treatment were assessed by VSS. The pain level was?span style="color: rgb(35, 31, 32); font-family: "Times New Roman"; font-size: 9.5pt;">evaluated by VAS at 1 h and 24 h after laser treatment. The quality of life was evaluated by DLQI. The positive expressions of?span style="color: rgb(35, 31, 32); font-family: "Times New Roman"; font-size: 9.5pt;">CK19 and p63 were detected by immunohistochemistry. The occurrence of adverse reactions during treatment in both groups?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">was recorded. Results The response rate of treatment in the observation group was higher than that in the control group?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">(95.12% vs 80.49%), the difference was statistically signififi cant (P＜0.05). After treatment, the pain time, decrustation time,wound healing time, VSS score, VAS score and DLQI score in the observation group were significantly lower than those in the?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">control group (P＜0.05). After 3 d of treatment, strong positive rates of CK19 and p63 in the observation group were higher?span style="font-size: 9.5pt; font-family: "Times New Roman"; color: rgb(35, 31, 32);">than those in control group, but there were no signififi cant difference between the two groups (P＞0.05). After 7 d of?span style="color: rgb(35, 31, 32); font-family: "Times New Roman"; font-size: 9.5pt;">treatment, strong positive rates of CK19 and p63 in the observation group were significantly higher than those?/span>in the control group (P＜0.05). After 3 months of treatment, incidence of adverse reactions in the observation group was?/span>lower than that in the control group (17.07% vs 31.71%), but there was no significant difference between the?/span>two groups (P＞0.05). Conclusion Ultra-pulsed fractional CO2 laser combined with MEBO external use has a signififi cant?/span>aesthetic effect in the treatment of scar after faciocervical burns, and can accelerate wound healing.

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备注/Memo

备注/Memo:
基金项目：2020年度南通市市级科技计划（指导性）项目（编号：MSZ20121）；2020年度市级临床医学中心项目（编号：HS2020006）
更新日期/Last Update: 2022-07-22