[1]杜 芳,杨亚利,张 杰,等.A型肉毒毒素对内眦赘皮矫正术后瘢痕新生血管的影响[J].中国美容医学,2022,(10):73-78.
　DU Fang,YANG Yali,ZHANG Jie,et al.Effects of Botulinum Toxin Type A on Neovascularization after Epicanthoplasty[J].Medical Aesthetics and Beauty,2022,(10):73-78.
点击复制

A型肉毒毒素对内眦赘皮矫正术后瘢痕新生血管的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年10期
页码:
73-78
栏目:
出版日期:
2022-10-10

文章信息/Info

Title:
Effects of Botulinum Toxin Type A on Neovascularization after Epicanthoplasty
文章编号:
1008-6455（2022）10-0073-05 Effects of Bo
作者:
杜 芳1 ; 杨亚利2 ; 张 杰3 ; 朱 凤1
(鄂州爱尔眼科医院 1.眼睑眼眶科;2.青光眼科;3.屈光科 湖北 鄂州 436000)
Author(s):
DU Fang1 ; YANG Yali2 ; ZHANG Jie3 ; ZHU Feng1
(1.Department of Eyelid and Orbit; 2.Department of Glaucoma; 3.Department of Refraction,Ezhou Aier Eye Hospital,Ezhou 436000,Hubei,China)
关键词:
A型肉毒毒素; 内眦赘皮矫正术; 新生血管; 瘢痕; 重复测量
Keywords:
botulinum toxin type A;  epicanthoplasty;  neovascularization;  scar;  repeated measures
分类号:
R587.1
文献标志码:
A
摘要:
目的：探讨A型肉毒毒素对内眦赘皮矫正术后瘢痕新生血管增殖的临床效果。方法：选取笔者所在医院整形科2016年7 月-2019年6月接受“Z”法内眦赘皮矫正术的50例女性就医者作为研究对象，随机分成观察组和对照组。观察组于术后1周拆 线时内眦区注入A型肉毒毒素，对照组术后未予注射。评估两组就医者术后2周、3周、1个月、2个月、3个月及6个月时内眦 瘢痕区新生血管增殖和瘢痕增生的情况。结果：两组新生血管计数、新生血管等级评分及瘢痕增生评分比较，差异有统计学 意义；观察组新生血管计数、新生血管评分及瘢痕增生评分均低于对照组（血管计数Wald χ2 =76.949，P＜0.05；血管评分 Wald χ2 =598.831，P＜0.05；瘢痕评分Wald χ2 =50.572，P＜0.05），重复测量时间比较结果显示新生血管计数及评分值均 在术后3周时最高，而瘢痕增生随着时间发展评分逐渐降低。结论：A型肉毒毒素可以抑制内眦赘皮矫正术后瘢痕新生血管的 增殖，从而抑制瘢痕的增生，术后早期作用效果显著。
Abstract:
Objective The aim of this research was to investigate the clinical effects of botulinum toxin type A on neovascularization after epicanthoplasty. Methods 50 female patients who underwent double blepharoplasty combined with "Z" method of endocanthal epidermis correction from July 2016 to June 2019 in the plastic surgery department of the hospital were selected as the research objects,who were randomly divided into observation group and control group. In the observation group, botulinum toxin type A was injected into the inner canthus region when the stitches was removed at one week after operation. Patients in control group were not injected with botulinum toxin type A after operation. The neovascularization and scar hyperplasia of all patients were evaluated at 2 weeks, 3 weeks, 1 month, 2 months, 3 months and 6 months after surgery,respectively. Results There were significant differences in the neovascularization number, neovascularization grade score and scar hyperplasia score between the two groups. The three data of the observation group, neovascularization number, neovascularization score and scar hyperplasia score, were lower than those of the control group (neovascularization number Wald χ2 =76.949, P＜0.05, neovascularization grade score Wald χ2 =598.831, P＜0.05, scar hyperplasia score Wald χ2 =50.572, P＜0.05). The comparison of repeated measurement time showed that the neovascularization count and score were the highest at 3 weeks after operation, while the scar hyperplasia score gradually decreased with time. Conclusion Botulinum toxin type A can inhibit the proliferation of scar neovascularization after epicanthoplasty, thus inhibiting the hyperplasia of scar.

相似文献/References:

[1]徐 娜,李 谆,岳 荣,等. 一点一针式重睑成形及内眦赘皮矫正术的临床应用[J].中国美容医学,2018,(03):41.
　XU Na,LI Zhun,YUE Rong,et al. Blepharoplasty and Canthus Correction Operation with a “One Point One Stitch Suture” Technique[J].Medical Aesthetics and Beauty,2018,(10):41.
[2]肖 洋,陈石海,陈从柏. 连续Y-V成形术联合糖皮质激素及A型肉毒毒素注射治疗瘢痕挛缩畸形[J].中国美容医学,2018,(08):51.
　XIAO Yang,CHEN Shi-hai,CHEN Cong-bo. Application of Continuous Y-V Plasty Combined with Glucocorticoid and Botulinum Toxin Type A in the Treatment of Scar Contracture[J].Medical Aesthetics and Beauty,2018,(10):51.
[3]卢 可,葛红梅,李平松. CO2点阵激光联合A型肉毒毒素透皮给药技术治疗面部痤疮瘢痕临床观察[J].中国美容医学,2018,(08):112.
　LU Ke,GE Hong-mei,LI Ping-song. Clinical Effect and Safety Observation of Fractional Ultra-Pulsed CO2 Laser Combined with Transdermal Delivery of Botulinum Toxin A in the Treatment of Acne Scars[J].Medical Aesthetics and Beauty,2018,(10):112.
[4]姚翠英,陈 芳. 眼周年轻化术后A型肉毒毒素联合透明质酸注射对眼周皱纹改善的效果评价[J].中国美容医学,2019,(02):100.
　YAO Cui-ying,CHEN Fang. Improved Effects Evaluation of Botulinum Toxin Type A Combined with HyaluronicAcid Injection on Periocular Wrinkle after Periocular Rejuvenation Surgery[J].Medical Aesthetics and Beauty,2019,(10):100.
[5]龚卫华,王 楷,周志春. 光纤溶脂联合A型肉毒毒素注射在下面部轮廓整形中的应用[J].中国美容医学,2019,(12):26.
　GONG Wei-hua,WANG Kai,ZHOU Zhi-chun. Application of Faber De-fatting Combined with Botulinum Toxin Type A Injection inthe Cosmetic Treatment of the Lower Contour[J].Medical Aesthetics and Beauty,2019,(10):26.
[6] 尚念胜,牛燕英. A型肉毒毒素对瘢痕疙瘩成纤维细胞TGF-/Smad通路和ERK通路表达的影响[J].中国美容医学,2020,(5):104.
　 SHANG Nian-sheng,NIU Yan-ying. Effects of Botulinum Toxin Type A on the Expression of TGF-β/Smad and ERKPathways in Keloid Fibroblasts[J].Medical Aesthetics and Beauty,2020,(10):104.
[7] 管晓玉 纪 覃 吴 灿 综述,白 南 审校. C02点阵激光治疗皮肤创伤性瘢痕的临床应用及研究进展[J].中国美容医学,2020,(7):169.
　 GUAN Xiao-yu,JI Tan,WU Can,et al. Clinical Application and Research Progress of CO2 Fractional Laser in the Treatmentof Traumatic Skin Scar:A Systematic Review of Literature[J].Medical Aesthetics and Beauty,2020,(10):169.
[8] 王露萍. 点阵CO2激光联合A型肉毒毒素治疗面颈部增生性瘢痕的效果研究[J].中国美容医学,2020,(8):81.
　 WANG Lu-ping. Study on the Cosmetic Effect of Dot Matrix CO2 Laser Combined with Botulinum ToxinType A of Facial and Neck Hypertrophic Scar[J].Medical Aesthetics and Beauty,2020,(10):81.
[9] 张林林,刁永力,徐 建,等. A型肉毒毒素联合氟尿嘧啶注射治疗烧伤瘢痕效果评估[J].中国美容医学,2020,(9):67.
　 ZHANG Lin-lin,DIAO Yong-li,XU Jian,et al. Effects of Botulinum Toxin Type A Combined with Fluorouracil on Burn Scar[J].Medical Aesthetics and Beauty,2020,(10):67.
[10] 高明菊,杨 名,吴炳为,等. A型肉毒毒素联合透明质酸治疗眉间纹效果探讨[J].中国美容医学,2020,(11):51.
　 GAO Ming-ju,YANG Ming,WU Bing-wei,et al. Effect of Botulinum Toxin Type A Combined with Hyaluronic Acid Injection in theTreatment of Glabellar Lines[J].Medical Aesthetics and Beauty,2020,(10):51.

更新日期/Last Update: 2022-10-20