[1]孔淑贞,王亮琪,张 静,等.光动力疗法治疗日光角化病的临床疗效及其影响因素分析[J].中国美容医学,2023,(7):114-118.[doi:10.15909/j.cnki.cn61-1347/r.005764]
　KONG Shuzhen,WANG LiangqiZHANG Jing,ZENG Weihui,et al.Assessment of the Clinical Effi cacy and Infl uencing Factors of Photodynamic Therapy in the Treatment of Actinic Keratosis[J].Medical Aesthetics and Beauty,2023,(7):114-118.[doi:10.15909/j.cnki.cn61-1347/r.005764]
点击复制

光动力疗法治疗日光角化病的临床疗效及其影响因素分析()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年7期
页码:
114-118
栏目:
出版日期:
2023-07-10

文章信息/Info

Title:
Assessment of the Clinical Effi cacy and Infl uencing Factors of Photodynamic Therapy in the Treatment of Actinic Keratosis
文章编号:
1008-6455（2023）07-0114-04
作者:
孔淑贞; 王亮琪; 张 静; 曾维惠; 耿松梅
(西安交通大学第二附属医院皮肤病院 陕西 西安 710004 )
Author(s):
KONG Shuzhen; WANG LiangqiZHANG Jing; ZENG Weihui; GENG Songmei
(Department of Dermatology,the Second Affi liated Hospital of Xian Jiaotong University,Xian 710004,Shaanxi,China)
关键词:
光动力疗法; 日光角化病; 临床疗效; 影响因素
Keywords:
photodynamic therapy;  actinic keratoses;  effi cacy;  infl uence factor
分类号:
R739.5
DOI:
10.15909/j.cnki.cn61-1347/r.005764
文献标志码:
A
摘要:
目的：评价光动力治疗日光角化病（Actinic keratosis，AK）的临床疗效，并探讨影响疗效的相关因素。方法：回 顾性分析2017年6月-2022年3月笔者医院采用光动力治疗AK的患者临床资料，并随访其临床疗效，进行单因素分析筛选后使 用有序多分类Logistic回归分析探讨影响疗效的主要因素。结果：共纳入116例AK患者，其中49例（42.24%）完全缓解，35 例（30.17%）部分缓解，32例无效（27.59%），总有效率72.41%；治疗次数3次及以上的AK患者治疗有效率为90.54%。有序多 分类Logistic回归分析结果显示治疗次数，皮损分级、皮损数量是影响治疗疗效的主要因素；治疗1～2次者疗效比治疗3次及 以上者差（OR=0.036，P＜0.05）；皮损分级低者（Olsen 1～2级）疗效优于皮损分级（3级）高者（OR=3.848，P＜0.05）； 皮损数量少者疗效较皮损多发者（≥3个）疗效更佳（OR=17.167，P＜0.05）。治疗期间AK患者均未发生严重的不良反应。 结论：单发、皮损厚度偏薄的日光角化病患者进行光动力治疗效果更佳，且治疗次数以3次以上为宜。性别、年龄、皮肤类 型、皮损直径等均不影响疗效。
Abstract:
Objective To assess the clinical effi cacy of photodynamic therapy in the treatment of actinic keratosis(AK), and explore its main infl uencing factors. Methods The AK patients treated by photodynamic therapy in the investigator’s hospital from June 2017 to March 2022 were retrospectively analyzed and followed up. The main aff ecting factors on the treatment effi cacy were done by univariate analysis and ordered multivariate logistic regression analysis. Results A total of 116 AK patients were included in the study. Of these, 49 patients (42.24%) achieved complete remission, 35 patients (30.17%) achieved partial remission, 32 patients were ineff ective (27.59%), and the total eff ective rate was 72.41%. Through ordered multivariate logistic regression analysis, the eff ective rate was 90.54% for patients with 3 or more times treatments; The results showed that the number of treatment times, the classifi cation and the number of skin lesions were the main factors aff ecting the therapeutic effi cacy. The patients who received 1-2 times had inferior effi cacy to those who had 3 or more times of treatment(OR=0.036 ， P ＜0.05); The effi cacy of patients with low-grade skin lesions (Olsen Grade 1-2) was better than those with high- grade skin lesions(Grade 3)（OR=3.848，P＜0.05); less number of lesions predicted better outcome than those with multiple lesions (≥ 3 lesions) (OR=17.167, P＜0.05). No patients had serious adverse reactions during treatment. Conclusion AK Patients who had fewer, thinner skin lesions would have better therapeutic effi cacy, and the times of treatment should be 3 or more. Sex, age, skin type, and lesion size did not aff ect the therapeutic effi cacy.

相似文献/References:

[1]耿文军,赵建华. 康复新液联合光动力疗法治疗玫瑰痤疮疗效研究[J].中国美容医学,2019,(08):66.
　GENG Wen-jun,ZHAO Jian-hua. Clinical Study of Kangfuxin Solution Combined with Photodynamic Therapy in theTreatment of Rosacea[J].Medical Aesthetics and Beauty,2019,(7):66.
[2] 胡中柱,张 萌. 光动力疗法联合加味附子理中汤治疗中重度寻常性痤疮的有效性和安全性研究[J].中国美容医学,2020,(6):106.
　 HU Zhong-zhu,ZHANG Meng. Study on the Efficacy and Safety of Photodynamic Therapy Combined with JiaweiFuzi Lizhong Decoction in the Treatment of Moderate and Severe Acne Vulgaris[J].Medical Aesthetics and Beauty,2020,(7):106.
[3] 高 妮,高 琳. 针刺配合光动力治疗颜面播散性粟粒性狼疮[J].中国美容医学,2020,(7):49.
　 GAO Ni,GAO Lin. Treatment of Lupus Miliaris Disseminatus Faciei with Needling Combined WithPhotodynamic Therapy[J].Medical Aesthetics and Beauty,2020,(7):49.
[4] 王 奕,胡利萍,廖程琦,等. Mohs手术与光动力疗法单独或联合应用治疗乳房外Paget病疗效观察[J].中国美容医学,2020,(10):61.
　 WANG Yi,HU Li-ping,LIAO Cheng-qi,et al. Efficacy of Mohs Surgery and PDT Alone or Combination in the Treatment ofExtramammary Paget’s Disease[J].Medical Aesthetics and Beauty,2020,(7):61.
[5] 刘玉东,史玉玲,李秀丽. 中西药联合5-氨基酮戊酸光动力疗法治疗囊肿型痤疮疗效观察[J].中国美容医学,2020,(12):16.
　 LIU Yu-dong,SHI Yu-ling,LI Xiu-li. Observation of Effect of Chinese and Western Medicine Combined with5-aminolevulinic Acid Photodynamic Therapy on Cystic Acne[J].Medical Aesthetics and Beauty,2020,(7):16.
[6] 夏 卉,赵 莉. 口服异维A酸联合光动力治疗重度痤疮疗效分析[J].中国美容医学,2021,(5):86.
　 XIA Hui,ZHAO Li. Analysis of Clinical Effect of Oral Isotretinoin Combined with Photodynamic Therapyon Severe Acne Patients[J].Medical Aesthetics and Beauty,2021,(7):86.
[7]郭 欣,喻书琛,李美文,等.吲哚菁绿介导的光动力疗法对牙周炎疗效的Meta分析[J].中国美容医学,2022,(1):111.
　GUO Xin,YU Shushen,LI Meiwen,et al.The Effect of Indocyanine Green-mediated Photodynamic Therapy in Treating Periodontitis: A Meta-analysis[J].Medical Aesthetics and Beauty,2022,(7):111.
[8]冉金凤,潘 鸿,何泽举,等.自拟清热消痤方联合光动力疗法治疗中重度痤疮疗效分析[J].中国美容医学,2022,(3):107.
　RAN Jinfeng,PAN Hong,HE Zeju,et al.Analysis of the Effect of Self-made Qingre Xiaocuo Prescription Combined with Photodynamic Therapy in Patients with Moderate to Severe Acne[J].Medical Aesthetics and Beauty,2022,(7):107.
[9]李颖慧,郭 芳,樊娟丽,等.光动力疗法治疗须疮疗效观察[J].中国美容医学,2023,(2):105.
　LI Yinghui,GUO Fang,FAN Juanli,et al.LI Yinghui,GUO Fang,FAN Juanli,NIU Jie[J].Medical Aesthetics and Beauty,2023,(7):105.
[10]袁黎黎,郑小勇.光动力疗法联合口服异维A酸治疗中重度痤疮的临床疗效及安全性分析[J].中国美容医学,2024,(1):82.[doi:10.15909/j.cnki.cn61-1347/r.006091]
　YUAN Lili,ZHENG Xiaoyong.Clinical Effi cacy and Safety Analysis of Photodynamic Therapy Combined with Oral Isotretinoin in the Treatment of Moderate to Severe Acne[J].Medical Aesthetics and Beauty,2024,(7):82.[doi:10.15909/j.cnki.cn61-1347/r.006091]

更新日期/Last Update: 2023-08-08