[1]肖洁银,陈 诚.脉冲染料激光与海姆泊芬光动力疗法治疗微静脉畸形的疗效对比分析[J].中国美容医学,2023,(9):107-111.[doi:10.15909/j.cnki.cn61-1347/r.005896]
　XIAO Jieyin,CHEN Cheng.Comparative Analysis of Effi cacy of Pulsed Dye Laser and Hemporfi n Photodynamic Therapy in the Treatment of Port-wine Stains[J].Medical Aesthetics and Beauty,2023,(9):107-111.[doi:10.15909/j.cnki.cn61-1347/r.005896]
点击复制

脉冲染料激光与海姆泊芬光动力疗法治疗微静脉畸形的疗效对比分析()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年9期
页码:
107-111
栏目:
出版日期:
2023-09-10

文章信息/Info

Title:
Comparative Analysis of Effi cacy of Pulsed Dye Laser and Hemporfi n Photodynamic Therapy in the Treatment of Port-wine Stains
文章编号:
1008-6455（2023）09-0107-04
作者:
肖洁银; 陈 诚
(武汉市第一医院皮肤科 湖北 武汉 430000 )
Author(s):
XIAO Jieyin; CHEN Cheng
(Department of Dermatology,Wuhan First Hospital,Wuhan 430000,Hubei,China)
关键词:
脉冲染料激光; 海姆泊芬光动力; 微静脉畸形; 临床疗效; 不良反应
Keywords:
pulsed dye laser;  Hemporfi n photodynamics;  port-wine stains;  clinical effi cacy;  adverse reactions
分类号:
R616.4
DOI:
10.15909/j.cnki.cn61-1347/r.005896
文献标志码:
A
摘要:
目的：分析595 nm脉冲染料激光（Pulsed dye laser，PDL）与海姆泊芬光动力疗法（Hemoporfin Photodynamic therapy ，HMME-PDT）治疗微静脉畸形的疗效差异。方法：回顾性分析2020年1月-2021年2月于笔者医院就诊的206例微静脉 畸形患者的临床资料，根据治疗方法分为观察组和对照组，各103例。观察组接受HMME-PDT治疗，对照组接受595 nm PDL治 疗。治疗后评估两组治疗有效率，比较两组患者面部不同分区的微静脉畸形治疗效果及治疗期间不良反应发生率。结果：治 疗后3个月时，观察组治疗有效率为70.87%，对照组为62.14%，组间比较差异无统计学意义（P＞0.05）；两组患者的性别、 年龄、颈部皮损、紫红型皮损及增厚型皮损的治疗有效率比较差异无统计学意义（P＞0.05），但观察组的面部皮损、四肢 躯干皮损及粉红型皮损的治疗有效率显著高于对照组（P＜0.05）；两组面部额鼻区、眶区及上颌区皮损的治疗有效率比较 差异无统计学意义（P＞0.05），但观察组面部下颌区皮损的治疗有效率显著高于对照组（P＜0.05）；治疗期间观察组的色 素沉着发生率显著高于对照组（P＜0.05）。结论：595 nm PDL、HMME-PDT疗法均可有效治疗微静脉畸形，但HMME-PDT疗法 在面部下颌区皮损、四肢躯干皮损及粉红型皮损中应用效果更佳，但易引发色素沉着，故临床应根据患者实际情况，灵活选 择治疗方式。
Abstract:
Objective Analyze the diff erences in the effi cacy of 595 nm pulsed dye laser (PDL) and hemporfi n photodynamic therapy (HMME-PDT) in the treatment of port-wine stains. Methods The clinical data of 206 patients with port-wine stains who were treated in the hospital were retrospectively analyzed between January 2020 and February 2021. According to the treatment methods, the patients were divided into the observation group and the control group with 103 cases in each group. The observation group received HMME-PDT treatment, while the control group was given 595 nm PDL treatment. The eff ective rate of treatment was evaluated in the two groups. The treatment eff ects of port-wine stains in diff erent areas of the face were compared between the two groups. The incidence rates of adverse reactions during treatment were recorded in the two groups. Results At 3 months after treatment, the eff ective rate of treatment was 70.87% in the observation group and 62.14% in the control group (P ＞0.05). There was no statistical diff erence in the eff ective rate of treatment between the two groups from the aspects of gender, age, neck lesions, purple-red skin lesions and thickened skin lesions (P＞0.05), but the eff ective rates of treatment of facial skin lesions, limb trunk skin lesions and pink-type skin lesions in the observation group were signifi cant higher than those in the control group (P ＜0.05). There were no statistical diff erences in the eff ective rates of treatment of lesions in facial frontal-nasal area, orbital area and maxillary area between the two groups (P ＞0.05), but the eff ective rate of treatment of facial mandibular area lesions in the observation group was signifi cantly higher than that in the control group (P ＜0.05). The incidence rate of hyperpigmentation in the observation group during treatment was signifi cantly higher than that in the control group (P ＜0.05). Conclusion 595 nm PDL and HMME-PDT can eff ectively treat port-wine stains. The latter one is more eff ective in facial mandibular area skin lesions, limb trunk skin lesions and pink-type skin lesions, but it is easy to cause hyperpigmentation, so it is necessary to fl exibly choose the treatment methods in clinical practice according to the actual situation of patients.

相似文献/References:

[1]张兰芳,雷 英,张兴安.532nm钾钛磷酸盐激光与595nm脉冲染料激光治疗面部痤疮后红斑疗效比较研究[J].中国美容医学,2018,(08):115.
　ZHANG Lan-fang,LEI Ying,ZHANG Xing-an. Clinical Study of 532nm Potassium Titanium Phosphate Laser and 595nm Pulsed Dye Laser in Treatment of Facial Acne-induced Erythema[J].Medical Aesthetics and Beauty,2018,(9):115.
[2]张嘉文 刘子菁 王小燕 Juliandri刘韵祎 马仁燕 综述,许 阳 审校. 玫瑰痤疮的光电治疗研究进展[J].中国美容医学,2019,(05):159.
　ZHANG Jia-wen,LIU Zi-jing,WANG Xiao-yan,et al. Research Progress of Photoelectric for Rosacea[J].Medical Aesthetics and Beauty,2019,(9):159.
[3] 骆 婧,宁金斌,赵红维,等. 脉冲染料激光联合CO2点阵激光治疗烧伤后增生性瘢痕疗效评价[J].中国美容医学,2020,(12):43.
　 LUO Jing,NING Jin-bin,ZHAO Hong-wei,et al. Evaluation on Curative Effect of Pulsed Dye Laser Combined with CO2 FractionalLaser on Hypertrophic Scar after Burn[J].Medical Aesthetics and Beauty,2020,(9):43.
[4] 徐晓静,朱元杰. 不同剂量异维A酸联合脉冲染料激光治疗酒渣鼻的疗效及安全性分析[J].中国美容医学,2021,(1):73.
　XU Xiao-jing,ZHU Yuan-jie. Efficacy and Safety of Different Doses of Isotretinoin Combined with Pulsed Dye Laserin the Treatment of Rosacea[J].Medical Aesthetics and Beauty,2021,(9):73.
[5] 任 盼 综述,马富鑫 喇雨萌 郑加伟 余 震审校. 激光治疗在增生性瘢痕不同病理阶段应用的研究进展[J].中国美容医学,2021,(1):180.
　 REN Pan,MA Fu-xin,LA Yu-meng,et al. Research Progress of Laser Treatment in Different Pathological Stagesof Hypertrophic Scars[J].Medical Aesthetics and Beauty,2021,(9):180.
[6] 王东岺. 点阵CO2激光联合PDL激光治疗瘢痕疙瘩的疗效及不良反应分析[J].中国美容医学,2021,(9):89.
　 WANG Dong-ling. Efficacy and Adverse Reactions of Fractional CO2 Laser combined with PDL Laser inthe Treatment of Keloid[J].Medical Aesthetics and Beauty,2021,(9):89.
[7]赖永平.IPL联合595 nm脉冲染料激光治疗玫瑰痤疮的疗效及安全性分析赖永平[J].中国美容医学,2022,(1):76.
　LAI Yongping.Efficacy and Safety of IPL Combined with 595 nm Pulsed Dye Laser in the Treatment of Acne Rosacea[J].Medical Aesthetics and Beauty,2022,(9):76.
[8]吴 灿 赵春苗 王士强 李 梁 综述,白 南 审校.点阵CO2激光治疗烧伤后瘢痕挛缩的临床应用及研究进展[J].中国美容医学,2022,(5):181.
[9]宫昕晨,陈明懿.不同脉宽595 nm染料激光联合5-FU治疗增生性瘢痕的疗效以及对瘢痕血 流灌注的影响[J].中国美容医学,2022,(12):87.
　GONG Xinchen,CHEN Mingyi.Effect of 595 nm Dye Laser Different Pulse Width Laser Combined with 5-FU on Hypertrophic Scar and Its Infl uence on Blood Perfusion[J].Medical Aesthetics and Beauty,2022,(9):87.
[10]陶 娅,陆 玲,盛敏兰,等.不同间隔时间脉冲染料激光治疗痤疮瘢痕的疗效观察[J].中国美容医学,2023,(2):85.
　TAO Ya,LU Ling,SHENG Minlan,et al.Curative Effect of Pulsed Dye Laser with Different Intervals on Acne Scars[J].Medical Aesthetics and Beauty,2023,(9):85.

更新日期/Last Update: 2023-09-26