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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2023年10期

页码:

109-112

栏目:

出版日期:

2023-10-10

文章信息/Info

Title:

Effi cacy and Safety Evaluation of Photodynamic Therapy Combined with Glycolic Acid in the Treatment of Papulopustular Rosacea

文章编号:

1008-6455（2023）10-0109-04

作者:

朱丽姣¹ ; 史可俊² ; 涂红琴² ; 冯秋元¹ ; 徐莲莲¹ ; 李宁溪¹

(宜兴市人民医院 1. 医疗美容科;2.皮肤科 江苏 无锡 214200 )

Author(s):

ZHU Lijiao¹ ; SHI Kejun² ; TU Hongqin² ; FENG Qiuyuan¹ ; XU Lianlian¹ ; LI Ningxi¹

(1.Department of Medical Beauty; 2.Department of Dermatology,Yixing People’s Hospital,Wuxi 214200, Jiangsu,China)

关键词:

玫瑰痤疮; 丘疹脓疱型; 光电协同技术; 果酸; 经皮水分流失量; 面部红斑

Keywords:

rosacea;  papulopustular subtype;  photodynamic therapy;  glycolic acid;  transepidermal water loss;  erythema

分类号:

R758.73+ 4

DOI:

10.15909/j.cnki.cn61-1347/r.005927

文献标志码:

A

摘要:

目的：探究光电协同技术联合果酸治疗丘疹脓疱型玫瑰痤疮的疗效及安全性。方法：选择宜兴市人民医院2021年4 月-2022年1月收治的92例丘疹脓疱型玫瑰痤疮患者作为研究对象。采用随机数字表法分为研究组46例和对照组46例，对照 组光电协同技术治疗，研究组采用光电协同技术联合果酸治疗。治疗16周后评估两组患者临床疗效、炎性皮损和非炎性皮 损减少率、面部红斑量、经皮水分流失量、焦虑情绪及治疗期间药物安全性。结果：两组治疗8周炎性皮损和非炎性皮损减 少率比较差异无统计学意义（P＞0.05）；治疗16周后，两组炎性皮损和非炎性皮损减少率均高于治疗8周后，且研究组炎 性皮损和非炎性皮损减少率均高于对照组（P＜0.05）。研究组治疗后临床有效率高于对照组（P＜0.05）。治疗后，两组 面部红斑量及经皮水分流失量均低于治疗前，研究组均低于对照组（P＜0.05）。两组治疗后汉密尔顿焦虑量表（Hamilton anxiety scale，HAMA）、汉密顿抑郁量表（Hamilton depression scale，HAMD）评分较治疗前均降低，研究组低于对照组 （P＜0.05）。两组不良反应发生率比较差异无统计学意义（P＞0.05）。结论：光电协同技术联合果酸治疗丘疹脓疱型玫瑰痤 疮，可有效促进患者皮损恢复、减少面部红斑量、降低经皮水分流失、改善患者焦虑情绪，临床疗效优越且安全性良好。

Abstract:

Objective Investigation of the efficacy and safety of photodynamic therapy combined with glycolic acid in the treatment of papulopustular rosacea. Methods Ninety-two patients with papulopustular rosacea admitted to Yixing People’s Hospital from April 2021 to January 2022 were enrolled as study subjects. They were randomly divided into a study group of 46 cases treated with photodynamic therapy combined with glycolic acid and a control group of 46 cases treated with photodynamic therapy alone, using a random number table. Clinical efficacy, reduction rates of inflammatory and noninfl ammatory skin lesions, facial erythema score, transepidermal water loss, anxiety, and medication safety during the treatment period were evaluated in both groups after 16 weeks of treatment. Results There was no statistically signifi cant diff erence in the reduction rates of infl ammatory and non- infl ammatory skin lesions between the two groups after 8 weeks of treatment (P ＞0.05). However, after 16 weeks of treatment, the reduction rates of infl ammatory and non- infl ammatory skin lesions were higher in both groups compared to those after 8 weeks of treatment, with the study group showing higher reduction rates than the control group (P ＜0.05). The clinical effi cacy rate in the study group was signifi cantly higher than that in the control group (P ＜0.05). After treatment, both groups showed a decrease in facial erythema score and transepidermal water loss compared to before treatment, with the study group showing lower values than the control group (P ＜0.05). The scores on the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were signifi cantly reduced in both groups after treatment compared to before treatment, with the study group having lower scores than the control group (P ＜0.05). There was no statistically signifi cant diff erence in the incidence of adverse reactions between the two groups (P ＞0.05). Conclusion The combination of photodynamic therapy with glycolic acid in the treatment of papulopustular rosacea has been shown to eff ectively promote skin lesion recovery, reduce facial erythema, decrease transepidermal water loss, and improve anxiety. It demonstrates superior clinical effi cacy and good safety profi le.

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更新日期/Last Update: 2023-11-03