[1]吴海东,刘 丹,黄 瑛,等.PRP凝胶联合莫匹罗星对小面积Ⅲ度烧伤患者肉芽组织中TIMP-1水平的影响[J].中国美容医学,2022,(4):56-58.
　WU Haidong,LIU Dan,HUANG Ying,et al.Effect of PRP Gel Combined with Mupirocin on TIMP-1 Level in Granulation Tissue of Patients with Small Area of Third Degree Burn[J].Medical Aesthetics and Beauty,2022,(4):56-58.
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PRP凝胶联合莫匹罗星对小面积Ⅲ度烧伤患者肉芽组织中TIMP-1水平的影响()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年4期
页码:
56-58
栏目:
出版日期:
2022-04-10

文章信息/Info

Title:
Effect of PRP Gel Combined with Mupirocin on TIMP-1 Level in Granulation Tissue of Patients with Small Area of Third Degree Burn
文章编号:
1008-6455（2022）04-0056-03
作者:
吴海东1; 刘 丹2; 黄 瑛1; 贺 胜1; 张 炜1; 章 强1
(1.鄂州市中心医院烧伤美容整形科 湖北 鄂州 436000 ;2.黄冈市疾病预防控制中心健康管理中心 湖北 黄冈 438000 )
Author(s):
WU Haidong1; LIU Dan2; HUANG Ying1; HE Sheng1; ZHANG Wei1; ZHANG Qiang1
(1.Department of Burn Cosmetology and Orthopaedics,Central Hospital of Ezhou City,Ezhou 436000,Hubei,China;2.Health Management Center,Huanggang Center for Disease Control and Prevention,Huanggang 438000,Hubei,China)
关键词:
富血小板血浆; 莫匹罗星; 烧伤; Ⅲ度; 小面积; 基质金属蛋白酶抑制剂-1; 临床疗效; 安全性
Keywords:
platelet rich plasma(PRP);  mupirocin;  burn;  third degree;  small area;  Tissue inhibitor of metallopmteinase-1(TIMP- 1);  clinical efficacy;  security
分类号:
R644
文献标志码:
A
摘要:
目的：探讨富血小板血浆（Platelet-rich plasma, PRP）凝胶联合莫匹罗星对小面积Ⅲ度烧伤患者肉芽组织中TIMP-1水平的影响。方法：选择2019年1月-2020年5月笔者医院收治的155例烧伤患者，根据入院顺序单号为对照组（莫匹罗星软膏治疗）78例，双号为观察组（PRP+莫匹罗星软膏治疗）77例，记录两组换药次数、愈合后皮肤质量、换药舒适度、敷料覆盖舒适度；比较两组7d、14d、21d创面愈合情况及肉芽组织中基质金属蛋白酶抑制剂-1(Tissue inhibitor of metallopmteinase-1，TIMP-1)水平；统计两组治疗过程中不良反应情况。结果：对照组换药次数多于观察组，观察组换药舒适度、敷料覆盖舒适度及愈合后皮肤质量优于对照组，差异有统计学意义（P＜0.05）。观察组治疗后各时间点创面愈合率均高于对照组，创面愈合时间少于对照组，差异有统计学意义（P＜0.05）。治疗后7d、14d对照组肉芽组织中TIMP-1水平均低于观察组，差异有统计学意义（P＜0.05）。对照组不良反应发生率12.82%高于观察组的3.90%，差异有统计学意义（P＜0.05）。结论：PRP凝胶联合莫匹罗星治疗能改善小面积Ⅲ度烧伤患者肉芽组织中TIMP-1水平，加快创面愈合，且安全性良好。
Abstract:
Objective To investigate the effect of platelet-rich plasma (PRP) gel combined with mupirocin on the level of TIMP-1 in granulation tissue of patients with small-area third-degree burns. Methods A total of 155 burn patients admitted to our hospital from January 2019 to May 2020 were selected. According to the order of admission, there were 78 cases in the control group (treated with mupirocin ointment) and 77 cases in the observation group (treated with PRP + mupirocin ointment). The number of dressing change, skin quality after dressing, dressing comfort and excipient comfort were recorded in two groups. The healing rate of 7 d, 14 d and 21 d in two groups was compared. And the level of tissue inhibitor of metalloproteinase-1 (TIMP-1) in granulation tissue. The adverse reactions during the treatment of the two groups were counted. Results The dressing change times in the control group were more than those in the observation group (P ＜0.05). The dressing change comfort, dressing coverage comfort and skin quality after healing in the observation group were better than those in the control group (P＜0.05). The wound healing rate of the observation group at 7 d and 14 d after treatment were higher than those of the control group, and the wound healing time was less than that of the control group (P＜0.05). After treatment, the level of TIMP-1 in granulation tissue in the control group was lower than those in the observation group at each time, and the differences were statistically significant (P＜0.05). The incidence of adverse reactions in the control group was 12.82%, higher than that in the observation group (3.90%, P＜0.05). Conclusion PRP gel combined with mupirocin can improve the level of TIMP-1 in granulation tissue and accelerate wound healing in patients with small area of third degree burn.

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更新日期/Last Update: 2022-05-05