[1]刘晓雪,聂梦茜,云小君.超脉冲点阵CO2激光联合外用表皮生长因子治疗面部痤疮凹陷性瘢痕的疗效及对炎症反应的影响[J].中国美容医学,2022,(10):43-47.
　LIU Xiaoxue,NIE Mengqian,YUN Xiaojun.Efficacy of Ultra-pulse Fractional CO2 Laser Combined with Epidermal Growth Factor for External Use in the Treatment of Depressed Facial Acne Scars and Its Influence on Inflammatory Response[J].Medical Aesthetics and Beauty,2022,(10):43-47.
点击复制

超脉冲点阵CO2激光联合外用表皮生长因子治疗面部痤疮凹陷性瘢痕的疗效及对炎症反应的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年10期
页码:
43-47
栏目:
出版日期:
2022-10-10

文章信息/Info

Title:
Efficacy of Ultra-pulse Fractional CO2 Laser Combined with Epidermal Growth Factor for External Use in the Treatment of Depressed Facial Acne Scars and Its Influence on Inflammatory Response
文章编号:
1008-6455（2022）10-0043-04
作者:
刘晓雪; 聂梦茜; 云小君
(湖北省襄州区人民医院皮肤科 湖北 襄阳 441000)
Author(s):
LIU Xiaoxue; NIE Mengqian; YUN Xiaojun
(Department of Dermatology,Xiangzhou District Peoples Hospital,Xiangyang 441000,Hubei,China)
关键词:
超脉冲点阵CO2激光; 外用表皮生长因子; 面部痤疮凹陷性瘢痕; 疗效; 炎症反应
Keywords:
ultra-pulse fractional CO2 laser;  epidermal growth factor for external use;  depressed facial acne scars;  efficacy;  inflammatory response
分类号:
R619+ .6
文献标志码:
A
摘要:
目的：研究超脉冲点阵CO2激光联合外用表皮生长因子治疗面部痤疮凹陷性瘢痕的疗效及对炎症反应的影响。方法： 选取2017年3月-2020年5月笔者医院116例面部痤疮凹陷性瘢痕的患者。按抽签法分为研究组及对照组，每组58例。对照 组给予超脉冲点阵CO2激光治疗，研究组在对照组治疗基础上外用表皮生长因子。观察两组患者疗效、炎症反应、不 良反应、症状改善情况、权重评分、皮肤定量分析及瘢痕改善情况。结果：研究组总有效率（96.55%）高于对照组 （84.48%，P＜0.05）；治疗后研究组疼痛持续时间、红斑持续时间、结痂时间及痂皮完全脱落时间均低于对照组（P＜0.05）；治疗 后两组斑点、红质、毛孔及皱纹评分均有所上升，且研究组高于对照组（P＜0.05）；治疗后ECCA、VSS评分有所下降，且研 究组低于对照组（P＜0.05）；治疗后IL-2、IL-6水平均有所下降，但研究组低于对照组；治疗后研究组炎症反应评分低于 对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：超脉冲点阵CO2激光联合外用表皮 生长因子可明显改善患者临床症状，缩短痂皮脱落时间，有效降低机体炎症反应，提高治疗效果。
Abstract:
Objective To study the efficacy of ultra-pulse fractional CO2 laser combined with epidermal growth factor for external use in treating depressed facial acne scars and its influence on inflammatory response. Methods A total of 116 patients with depressed facial acne scars in our hospital were selected between March 2017 and May 2020, and they were divided into study group and control group according to the lottery method, with 58 cases in each group. Control group was given ultrapulse fractional CO2 laser treatment, and study group was additionally treated with epidermal growth factor for external use on the basis of control group. The efficacy, inflammatory response, adverse reactions, symptom improvement, weight score, quantitative analysis of skin and scar improvement were observed in the two groups of patients. Results The total effective rate of study group was higher than that of control group (96.55% vs 84.48%, P＜0.05). After treatment, the duration of pain, erythema duration, crusting time and complete scab shedding time of study group were shorter than those of control group (P ＜0.05). After treatment, the scores of fleck, red cutin, pores and wrinkles were increased in the two groups, and the scores of study group were higher than those of control group (P＜0.05). After treatment, the scores of ECCA and VSS were decreased, and the scores were lower in study group than in control group (P＜0.05). The levels of IL-2 and IL-6 after treatment were decreased, but the levels of study group were lower than those of control group. After treatment, the score of inflammatory response of study group was lower than that of control group (P＜0.05). The differences between the two groups were not significant in terms of incidence rates of adverse reactions (P＞0.05). Conclusion Ultra-pulse fractional CO2 laser combined with epidermal growth factor for external use can significantly improve the clinical symptoms, shorten the scab shedding time, effectively reduce the body’s inflammatory response and enhance the treatment effect.

相似文献/References:

[1]林 琳,宋俊红,陈立荣.透明质酸敷料联合超脉冲点阵CO2激光对面部痤疮凹陷性瘢痕患者瘢痕 修复情况及疼痛程度的影响[J].中国美容医学,2021,(11):48.
　LIN Lin,SONG Jun-hong,CHEN Li-rong.Effects of Hyaluronic Acid Dressing Combined with Ultra-pulse CO2 Fractional Laser on Scar Repair and Pain Degree in Patients with Depressed Facial Acne Scar[J].Medical Aesthetics and Beauty,2021,(10):48.
[2]杨 帅,蒋小姣,马海燕.超脉冲点阵CO2激光联合窄谱强脉冲光治疗创伤后早期增生性瘢痕效果分析[J].中国美容医学,2022,(2):58.
　YANG Shuai,JIANG Xiaojiao,MA Haiyan.Effect Analysis of Early Treatment of Post-traumatic Hypertrophic Scar with Ultra-pulsed Fractional CO2 Laser Combined with Dye Pulse Light[J].Medical Aesthetics and Beauty,2022,(10):58.
[3]范林明,马 飞,李 晟,等.超脉冲点阵CO2激光联合强脉冲光在皮肤年轻化治疗中的效果及安全性分析[J].中国美容医学,2022,(3):29.
　FAN Linming,MA Fei,LI Sheng,et al.Application Effect and Safety of Ultra-pulse Fractional CO2 Laser Combined with Intense Pulsed Light in Skin Rejuvenation[J].Medical Aesthetics and Beauty,2022,(10):29.
[4]徐圣经,张 敏,徐文静,等.超脉冲点阵CO2激光联合rh-bFGF治疗凹陷性痤疮瘢痕的疗效及对ECCA评分的影响[J].中国美容医学,2022,(11):42.
　XU Shengjing,ZHANG Min,XU Wenjing,et al.Efficacy of Ultra-pulsed Fractional CO2 Laser Combined with Epidermal Growth Factor rh-bFGF in the Treatment of Depressed Acne Scars and Its Impact on ECCA Score[J].Medical Aesthetics and Beauty,2022,(10):42.
[5]谷明娟,郭果香,胡春敏,等.重组人表皮生长因子外用联合超脉冲点阵CO2激光治疗面部痤疮凹陷性瘢痕疗效分析[J].中国美容医学,2023,(2):89.
　GU Mingjuan,GUO Guoxiang,HU Chunmin,et al.Curative Effect of Recombinant Human Epidermal Growth Factor for External Application Combined with Ultra-pulse CO2 fractional Laser on Facial Depressed Acne Scars[J].Medical Aesthetics and Beauty,2023,(10):89.
[6]潘廷猛,陈雪路,施 雯.超脉冲点阵CO2激光联合皮下分离术治疗萎缩性痤疮瘢痕临床观察[J].中国美容医学,2023,(6):82.
　PAN Tingmeng,CHEN Xuelu,SHI Wen.Clinical Observation of Ultrapulse Fractional CO2 Laser Combined with Subcision in the Treatment of Atrophic Acne Scars[J].Medical Aesthetics and Beauty,2023,(10):82.
[7]杨 松,余 晴,陈丽娜,等.超脉冲点阵CO2激光及舒敏保湿特护霜联合小针刀皮下剥离术治疗痤疮凹陷性瘢痕[J].中国美容医学,2023,(9):100.[doi:10.15909/j.cnki.cn61-1347/r.005884]
　YANG Song,YU Qing,CHEN Lina,et al.Ultra-pulse Fractional CO2 Laser Combined with Soothing Moisturizing Repairing Cream and Micro-Needling Subcision on the Treatment of Acne Atrophic Scars[J].Medical Aesthetics and Beauty,2023,(10):100.[doi:10.15909/j.cnki.cn61-1347/r.005884]
[8]徐亚楠,杜宝林,康格格.超脉冲点阵CO2激光联合5%米诺地尔酊治疗斑秃疗效分析[J].中国美容医学,2024,(9):83.
　XU Yanan,DU Baolin,KANG Gege.Effect of Sultra-pulsed Fractional Carbon Dioxide Laser Combined with 5% Minoxidil Tincture in the Treatment of Alopecia Areata[J].Medical Aesthetics and Beauty,2024,(10):83.

更新日期/Last Update: 2022-10-18