[1]杨瑞海,王云鹏.中药浸泡联合ALA-PDT治疗跖疣的疗效及对患者调节性T细胞、 TGF-β 、IFN-γ的影响[J].中国美容医学,2023,(4):111-114.
　YANG Ruihai,WANG Yunpeng.Effects of Traditional Chinese Medicine Soaking Combined with ALA-PDT on Plantar Warts and Its Effects on Regulatory T Cells,TGF- and IFN-γ[J].Medical Aesthetics and Beauty,2023,(4):111-114.
点击复制

中药浸泡联合ALA-PDT治疗跖疣的疗效及对患者调节性T细胞、 TGF-β 、IFN-γ的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年4期
页码:
111-114
栏目:
出版日期:
2023-04-10

文章信息/Info

Title:
Effects of Traditional Chinese Medicine Soaking Combined with ALA-PDT on Plantar Warts and Its Effects on Regulatory T Cells,TGF- and IFN-γ
文章编号:
1008-6455（2023）04-0111-03
作者:
杨瑞海; 王云鹏
(日照市皮肤病防治所皮肤科 山东 日照 276800 )
Author(s):
YANG Ruihai; WANG Yunpeng
(Department of Dermatology,Rizhao Institute of Dermatology,Rizhao 276800,Shandong,China)
关键词:
跖疣; 5-氨基酮戊酸光动力疗法; 中药浸泡; 调节性T细胞; 转化生长因子-β; 干扰素-γ
Keywords:
plantar warts;  5-aminolevulinic acid photodynamic therapy;  traditional chinese medicine soaking;  regulatory T cells;  transforming growth factor-;  interferon 102;  102);  font-family: Arial;  Verdana;  sans-serif;  font-size: 12px;  background-color: rgb(255;  255;  255); ">- 102;  102);  font-family: Arial;  Verdana;  sans-serif;  font-size: 12px; ">γ
分类号:
R275.9
文献标志码:
A
摘要:
目的：探讨中药浸泡联合5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)治疗 跖疣的疗效及其对调节性T细胞、转化生长因子-β(Transforming growth factor-β,TGF-β)、γ-干扰素(Interferonγ,IFN-γ)的影响。方法：按照随机数字表法将2019年1月-2020年12月笔者医院收治的160例跖疣患者分为对照组和观 察组，每组80例。对照组使用ALA-PDT(每隔20天1次，共3次)，观察组使用中药浸泡(每天1次)联合ALA-PDT。比较两组的 临床疗效、疣体评分、外周血CD4+ CD25+ CD127dim/-Treg水平、血清TGF-β、IFN-γ水平，不良反应及复发率。结果：观察 组总有效率92.50%，明显高于对照组80.00%，差异有统计学意义(P＜0.05)。治疗后，观察组的疣体评分[(0.39±0.0.4) 分 vs (1.05±0.16) 分]、外周血CD4+ CD25+ CD127dim/-Treg水平[(6.90±1.04)×105 个 vs (8.72±2.58)×105 个]及血清 TGF-β[(0.75±0.16)ng/ml vs (1.02±0.21)ng/ml] 明显低于对照组，血清IFN-γ水平[(5.63±1.14)ng/L vs (4.09±1.02)ng/L]明 显高于对照组，差异均有统计学意义(P＜0.05)。观察组的复发率（5.00%）明显低于对照组（18.75%），差异有统计学意义 (P ＜0.05)。两组不良反应发生情况比较，差异无统计学意义(P＞0.05)。结论：中药浸泡联合ALA-PDT治疗跖疣疗效显著， 安全性好，能有效调节免疫-炎症反应，降低复发率。
Abstract:
Objective To investigate the eff ects of Traditional Chinese Medicine(TCM) soaking combined with 5-aminolevulinic acid photodynamic therapy(ALA-PDT) on plantar warts and its effects on regulatory T cells, transforming growth factorβ(TGF-β) and interferon-γ(IFN-γ). Methods According to random number table method, a total of 160 patients with plantar warts who were divided into control group and observation group in the author’s hospital from January 2019 to December 2020, with 80 patients in each group. The control group was given ALA-PDT(once every 20 days, three times in total), and the observation group was given TCM soaking(once a day) combined with ALA-PDT. The clinical effi cacy, warts score, peripheral blood levels of CD4+ CD25+ CD127dim/-Treg , serum levels of TGF-βand IFN-γ, adverse reactions and recurrence rates were compared between two groups. Results The total eff ective rates(92.50% vs 80.00%) in the observation group was signifi cantly higher than that in the control group(P ＜0.05). The warts score[(0.39±0.0.4)points vs (1.05±0.16)points], peripheral blood levels of CD4+ CD25+ CD127dim/-Treg [(6.90±1.04)×105 vs (8.72±2.58)×105 ],the serum TGF-β [(0.75±0.16)ng/ml vs (1.02±0.21) ng/ml] was signifi cantly lower than that of the control group.The serum levels of IFN-γ[(5.63±1.14)ng/L vs (4.09±1.02) ng/L] in the observation group was significantly higher than that in the control group(P ＜0.05). The recurrence rates (5.00% vs 18.75%)in the observation group was signifi cantly lower than that in the control group(P ＜0.05). There was no signifi cant diff erence in adverse reactions between the two groups(P ＞0.05). Conclusion TCM soaking combined with ALAPDT had signifi cant eff ect and good safety on plantar warts. It could eff ectively regulate the immune- infl ammatory response and reduce the recurrence rates.

相似文献/References:

[1] 熊斯颖,杨 艳,邵 蕾,等. 浅表切削联合光动力疗法治疗面部鳞状细胞癌的疗效与安全性探析[J].中国美容医学,2020,(8):59.
　 XIONG Si-ying,YANG Yan,SHAO Lei,et al. Clinical Effect and Safety of Superfi cial Resection Combined with PhotodynamicTherapy for Facial Squamous Cell Carcinoma[J].Medical Aesthetics and Beauty,2020,(4):59.
[2] 潘继升,张杨梅,张 玲,等. 三联综合疗法与二氧化碳激光治疗跖疣疗效比较[J].中国美容医学,2020,(9):26.
　 PAN Ji-sheng,ZHANG Yang-mei,ZHANG Ling,et al. Comparison of Curative Effect of Triad Combined Therapy and Carbon Dioxide LaserTreatment on Plantar Wart[J].Medical Aesthetics and Beauty,2020,(4):26.
[3]谢其美,张彩云,张乐其.5-氨基酮戊酸光动力疗法联合小剂量米诺环素治疗玫瑰痤疮疗效分析[J].中国美容医学,2022,(2):54.
　XIE Qimei,ZHANG Caiyun,ZHANG Leqi.Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy Combined with Small Dose Minocycline in the Treatment of Rosacea[J].Medical Aesthetics and Beauty,2022,(4):54.
[4]黄 玲,胡伟才.温热疗法治疗跖疣的皮肤镜下疗效及对CD3+ 、CD4+ 、CD4+ /CD8+ 水平的影响研究[J].中国美容医学,2023,(2):78.
　HUANG Ling,HU Weicai.Study on the Therapeutic Effect of Thermotherapy on Plantar Warts under Dermoscopy and Its Effects on Levels of CD3+ ,CD4+ ,and CD4+ /CD8+[J].Medical Aesthetics and Beauty,2023,(4):78.
[5]彭晓艳,李双琴,胡 霞,等.5-氨基酮戊酸光动力疗法对中重度痤疮炎症性皮损和炎症后红斑的影响[J].中国美容医学,2023,(11):103.[doi:10.15909/j.cnki.cn61-1347/r.005977]
　PENG Xiaoyan,LI Shuangqin,HU Xia,et al.Effects of Photodynamic Therapy with 5-aminolevulinic Acid on Infl ammatory Skin Lesions and Post-infl ammatory Erythema in Moderate and Severe Acne[J].Medical Aesthetics and Beauty,2023,(4):103.[doi:10.15909/j.cnki.cn61-1347/r.005977]
[6]邓仁远,吴思蓝,欧阳俏玲,等.ALA-PDT红蓝光交替照射联合30%超分子水杨酸治疗寻常痤疮疗效观察[J].中国美容医学,2024,(10):41.
　DENG Renyuan,WU Silan,OUYANG Qiaoling,et al.Effi cacy of ALA-PDT Alternating Red and Blue Light Irradiation Combined with 30%[J].Medical Aesthetics and Beauty,2024,(4):41.

更新日期/Last Update: 2023-05-15