[1]彭 亮,牟双梦,杨凤超.复方甘草酸苷片联合重组牛碱性成纤维细胞生长因子治疗糖皮质激素依赖性皮炎疗效评价[J].中国美容医学,2022,(1):72-75.
　PENG Liang,MOU Shuangmeng,YANG Fengchao.Evaluation of the Cosmetic Effect of Compound Glycyrrhizin Tablets Combined with Recombinant Bovine Basic Fibroblast Growth Factor in Patients with Glucocorticoid-dependent Dermatitis[J].Medical Aesthetics and Beauty,2022,(1):72-75.
点击复制

复方甘草酸苷片联合重组牛碱性成纤维细胞生长因子治疗糖皮质激素依赖性皮炎疗效评价()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年1期
页码:
72-75
栏目:
出版日期:
2022-01-10

文章信息/Info

Title:
Evaluation of the Cosmetic Effect of Compound Glycyrrhizin Tablets Combined with Recombinant Bovine Basic Fibroblast Growth Factor in Patients with Glucocorticoid-dependent Dermatitis
文章编号:
1008-6455（2022）01-0072-04
作者:
彭 亮1; 牟双梦2; 杨凤超1
(雅安职业技术学院附属医院 1. 药剂科;2.皮肤科 四川 雅安 625000 )
Author(s):
PENG Liang1; MOU Shuangmeng2; YANG Fengchao1
(1.Department of Pharmacy; 2.Department of Dermatology,Affiliated Hospital of Ya’an Vocational and Technical College, Ya’an 625000,Sichuan,China)
关键词:
糖皮质激素依赖性皮炎; 复方甘草酸苷片; 重组牛碱性成纤维细胞生长因子; 氯雷他定片
Keywords:
glucocorticoid-dependent dermatitis;  compound glycyrrhizin tablets;  recombinant bovine basic fibroblast growth factor;  desloratadine citrate tablets
分类号:
R758.22
文献标志码:
A
摘要:
目的：探讨复方甘草酸苷片联合重组牛碱性成纤维细胞生长因子治疗糖皮质激素依赖性皮炎的美容效果。方法：选择2019年2月-2020年2月笔者医院收治的80例糖皮质激素依赖性皮炎患者，按随机数字表法分为试验组和对照组，每组40例。对照组给予氯雷他定片进行治疗，试验组在对照组的基础上给予复方甘草酸苷片联合重组牛碱性成纤维细胞生长因子凝胶进行治疗，两组均持续治疗2个月。比较两组治疗期间的临床指标及不良反应，治疗前后的症状积分及皮肤指标。结果：治疗期间，试验组起效、自觉症状消失、客观体征消失及痊愈时间均短于对照组，差异有统计学意义（P＜0.05）。与治疗前比较，治疗后两组自觉症状、客观体征评分、症状总积分及经皮水分丢失量均降低，试验组低于对照组，差异有统计学意义（P＜0.05）；而表皮皮脂含量、皮肤角质层含水量均升高，试验组高于对照组，差异有统计学意义（P＜0.05）。试验组治疗期间的不良反应发生率（12.50%）与对照组（20.00%）比较,差异无统计学意义（P＞0.05）。结论：复方甘草酸苷片联合重组牛碱性成纤维细胞生长因子可促进糖皮质激素依赖性皮炎患者皮肤屏障修复，进而有助于改善患者临床症状及体征，且安全性好。
Abstract:
Objective To investigate the cosmetic effect of compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor in patients with glucocorticoid-dependent dermatitis. Methods 80 patients with glucocorticoid-dependent dermatitis admitted to our hospital between February 2019 and February 2020, and divided into the test group and the control group by the random number table method,with 40 cases in each group. The control group was treated with desloratadine citrate tablets,and the test group was treated with compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel on the basis of the control group. Both groups continued treatment for 2 months. The clinical indicators,adverse reactions during treatment, the symptom scores and skin indicators before and after treatment were compared between the two groups. Results During treatment,the onset of effect,disappearance of conscious symptoms, disappearance of objective signs and recovery time in the test group were shorter than the control group (P ＜0.05). Compared with before treatment, after treatment, the scores of subjective symptoms, objective signs and total symptom, and the amount of transcutaneous water loss in the two groups decreaseed, the test group was lower than the control group (P＜0.05), while the sebum content and skin stratum corneum water content in the two groups increased, the test group was higher than the control group (P＜0.05). The incidence of adverse reactions during treatment in the test group (12.50%) and the control group (20.00%) were not obviously different (P＞0.05). Conclusion Compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor could significantly promote skin barrier repair in patients with glucocorticoid-dependent dermatitis,thereby helping to improve the clinical symptoms and signs of patients with high safety

相似文献/References:

[1]齐显龙 综述,杨宪伟 审校. 敏感皮肤的整合治疗[J].中国美容医学,2018,(10):21.
　QI Xian-long,YANG Xian-wei. Integrated Treatment of Sensitive Skin[J].Medical Aesthetics and Beauty,2018,(1):21.
[2]文丽萍,周书帆,邓 映,等. 短波理疗联合强脉冲光治疗面部糖皮质激素依赖性皮炎临床观察[J].中国美容医学,2018,(11):36.
　WEN Li-ping,ZHOU Shu-fan,DENG Ying,et al. Clinical Observation of Desensitization Apparatus Combined with Intense PulsedLight in the Treatment of Facial Glucocorticosteroid-dependent Dermatitis[J].Medical Aesthetics and Beauty,2018,(1):36.
[3] 吉 津,章若画,严 炯,等. 他克莫司联合复方甘草酸苷片对白癜风稳定期患者血清Th1/Th2型细胞因子水平的影响[J].中国美容医学,2020,(5):48.
　 JI Jin,ZHANG Ruo-hua,YAN Jiong,et al. The Effect of Tacrolimus Combined with Glycyrrhizic Acid Tablet on the Level of Th1/Th2 Cytokines in Patients with Stable Vitiligo[J].Medical Aesthetics and Beauty,2020,(1):48.
[4] 童海涛,吴桥芳,Shehzad Gopee,等. 1%吡美莫司乳膏联合多磺粘多糖乳膏治疗面部糖皮质激素依赖性皮炎疗效观察[J].中国美容医学,2020,(12):30.
　 TONG Hai-tao,WU Qiao-fang,Shehzad Gopee,et al. Clinical Efficacy of Topical Pimelimus Cream Combined with MucopolysaccharidePolysulfate Cream in Treating Corticosteroid Dependent Facial Dermatitis[J].Medical Aesthetics and Beauty,2020,(1):30.
[5] 黄飞飞. 阿维A胶囊联合复方甘草酸苷片治疗中重度痤疮疗效及对性激素与血清炎症因子的影响[J].中国美容医学,2021,(9):99.
　 HUANG Fei-fei. Efficacy of Avitamin A Capsule Combined with Compound Glycyrrhizin Tablet in theTreatment of Moderate and Severe Acne and Its Effects on Sex Hormones, SerumInflammatory Factors[J].Medical Aesthetics and Beauty,2021,(1):99.
[6]祁兴岩,来学民,张 晶.氦氖激光联合复方甘草酸苷片治疗面部寻常痤疮疗效观察[J].中国美容医学,2021,(12):89.
　QI Xing-yan,LAI Xue-min,ZHANG Jing.Curative Effect of He-Ne Laser Combined with Compound Glycyrrhizin Tablets on Facial Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(1):89.
[7]冯 琴,梁 琼,魏林林,等.重组牛碱性成纤维细胞生长因子联合强脉冲光对糖皮质激素依赖性皮炎患者皮肤屏障功能的影响[J].中国美容医学,2022,(10):59.
　FENG Qin,LIANG Qiong,WEI Linlin,et al.Effects of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Intense Pulse Light on Skin Barrier Function in Patients with Glucocorticoiddependent Dermatitis[J].Medical Aesthetics and Beauty,2022,(1):59.
[8]陈春秀,吴楚琪,梁 露,等.基于三焦理论分期论治糖皮质激素依赖性皮炎[J].中国美容医学,2023,(5):124.
　CHEN Chunxiu,WU Chuqi,LIANG Lu,et al.Treatment of Hormone Dependence Dermatitis based on Sanjiao theory[J].Medical Aesthetics and Beauty,2023,(1):124.
[9]何 慧,桂季滔,汪 俊,等.超高频超声在糖皮质激素依赖性皮炎患者皮肤屏障功能评价中的应用[J].中国美容医学,2023,(11):91.[doi:10.15909/j.cnki.cn61-1347/r.005998]
　HE Hui,GUI Jitao,WANG Jun,et al.Application of Ultra-high Frequency Ultrasound in the Evaluation of Skin Barrier Function in Patients with Facial Corticosteroid Addictive Dermatitis[J].Medical Aesthetics and Beauty,2023,(1):91.[doi:10.15909/j.cnki.cn61-1347/r.005998]
[10]杨学军,黄淑琼,杨定彬,等.复方甘草酸苷片联合舒缓保湿修护霜在面部敏感性皮肤治疗中的应用[J].中国美容医学,2023,(11):107.[doi:10.15909/j.cnki.cn61-1347/r.005984]
　YANG Xuejun,HUANG Shuqiong,YANG Dingbin,et al.Application of Compound Glycyrrhizin Tablets Combined with Anti-sensitive Repairing Cream on Sensitive Skin[J].Medical Aesthetics and Beauty,2023,(1):107.[doi:10.15909/j.cnki.cn61-1347/r.005984]

更新日期/Last Update: 2022-02-07