[1]杨晓敏,徐婷婷,段迎晓.不同负压创面治疗技术对糖尿病足的修复效果比较[J].中国美容医学,2023,(1):38-41.
　YANG Xiaomin,XU Tingting,DUAN Yingxiao.Comparison of Different Negative Pressure Wound Therapyin the Repair of Diabetes Foot[J].Medical Aesthetics and Beauty,2023,(1):38-41.
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不同负压创面治疗技术对糖尿病足的修复效果比较()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年1期
页码:
38-41
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Comparison of Different Negative Pressure Wound Therapyin the Repair of Diabetes Foot
文章编号:
1008-6455（2023）01-0038-04
作者:
杨晓敏1; 徐婷婷1; 段迎晓2
(文昌市人民医院 1.内分泌科;2.呼吸内科 海南 文昌 571300)
Author(s):
YANG Xiaomin1; XU Tingting1; DUAN Yingxiao2
(1.Department of Gastroenterology and Endocrinology; 2.Department of Respiratory Medicine,Wenchang Peoples Hospital,Wenchang 571300,Hainan,China)
关键词:
糖尿病足; 负压创面治疗; 负压封闭引流; 负压辅助闭合; 血管内皮生长因子
Keywords:
diabetic foot;  negative pressure wound therapy;  vacuum sealing drainage;  vacuum-assisted closure;  vascular endothelial growth factor
分类号:
R622
文献标志码:
A
摘要:
目的：分析比较负压辅助闭合（Vacuum-assisted closure，VAC）、负压封闭引流（Vacuum sealing drainage，VSD）两种负压创面治疗（Negative pressure wound therapy，NPWT）对糖尿病足（Diabetic foot，DF）的修复效果。方法：纳入2018年1月-2020年7月收治的80例DF患者作为研究对象，采用随机数表法进行简单随机抽样，将患者分为VAC组和VSD组，每组40例。两组均对创面进行NPWT，VAC组采用VAC法，VSD组采用VSD法。比较两组患者疗效，评估患者恢复情况，比较两组治疗前、治疗2周后血清细胞因子水平[内皮素-1（Endothelin-1，ET-1）、血管内皮生长因子（Vascular endothelial growth factor，VEGF）、肿瘤坏死因子α（Tumor necrosis factor α，TNF-α）]、氧化应激标志物[超氧化物歧化酶（Superoxide dismutase，SOD）、一氧化氮（Nitric oxide，NO）、脂质过氧化物丙二醛（Lipid peroxide malondialdehyde，MDA）]，随访记录患者预后情况。结果：两组临床疗效比较，差异无统计学意义（P＞0.05）。VAC组创基准备时间、创面治愈时间和住院时间均短于VSD组（P＜0.05）。治疗2周后，两组ET-1、TNF-α、MDA水平均低于治疗前，VEGF、SOD、NO水平均高于治疗前，差异有统计学意义（P＜0.05）；且VAC组ET-1、MDA、VEGF、SOD、NO变化幅度大于VSD组，差异有统计学意义（P＜0.05）。两组复发率比较，差异无统计学意义（P＞0.05）。结论：VAC、VSD治疗DF均能促进创面修复，但VAC较VSD在缩短恢复时间上更有优势。
Abstract:
Objective To analyze and compare the repair eff ects of two negative pressure wound treatment therapy (NPWT) of vacuum-assisted closure (VAC) and vacuum sealing drainage (VSD) on diabetic foot (DF). Methods A total of 80 patients with DF who were admitted between January 2018 and July 2020 were included as the research subjects. The patients were divided into the VAC group and the VSD group by simple random sampling of the random number table method, with 40 cases in each group. The two groups underwent NPWT for wound, and VAC group was treated with VAC method, and VSD group was treated with VSD method. The effi cacy was compared between the two groups, and the recovery status of patients were evaluated. The levels of serum cytokines (ET-1,VEGF and TNF-α) and oxidative stress markers (SOD, NO and MDA) were compared between the two groups before treatment and after 2 weeks of treatment, and the prognosis was followed up and recorded. Results There was no statistical signifi cance in clinical effi cacy between the two groups (P＞0.05). The preparation time of wound base, wound healing time and hospital stay in the VAC group were shorter than those in the VSD group, the diff erences were statistically signifi cant (P＜0.05). After 2 weeks of treatment, the levels of ET-1, TNF-α and MDA in the two groups were lower than those before treatment, while the levels of VEGF, SOD and NO were higher than those before treatment (P＜0.05). And the changes of ET-1、MDA、VEGF、SOD and NO in the VAC group were greater than those in the VSD group (P＜0.05). There was no statistical difference in the recurrence rate between the two groups (P＞0.05). Conclusion Both VAC and VSD in the treatment of DF can promote wound repair, but VAC has an advantage over VSD in shortening the recovery time

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更新日期/Last Update: 2023-01-29