[1]叶维奇,王 浩,黄书润,等.活性因子敷料结合负压封闭引流对深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形的影响[J].中国美容医学,2023,(3):38-41.
　YE Weiqi,WANG Hao,HUANG Shurun,et al.Effects of Active Factor Dressing Combined with Wound Vacuum Sealing Drainage on Scar Contracture Deformity After Wound Healing in Deep Degree- Burn[J].Medical Aesthetics and Beauty,2023,(3):38-41.
点击复制

活性因子敷料结合负压封闭引流对深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年3期
页码:
38-41
栏目:
出版日期:
2023-03-10

文章信息/Info

Title:
Effects of Active Factor Dressing Combined with Wound Vacuum Sealing Drainage on Scar Contracture Deformity After Wound Healing in Deep Degree- Burn
文章编号:
1008-6455(2023)03-0038-04
作者:
叶维奇; 王 浩; 黄书润; 郭少榕
(中国人民解放军联勤保障部队第910医院烧伤整形科 福建 泉州 362000 )
Author(s):
YE Weiqi; WANG Hao; HUANG Shurun; GUO Shaorong
(Department of Burns and Plastic Surgery,the 910th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,Quanzhou 362000,Fujian,China)
关键词:
活性因子敷料; 负压封闭引流; 深Ⅱ度烧伤; 瘢痕挛缩畸形; 温哥华瘢痕量表
Keywords:
active factor dressing;  vacuum sealing drainage;  deep degree- burn;  scar contracture deformity;  vancouver scar scale
分类号:
R622
文献标志码:
A
摘要:
目的：探讨活性因子敷料结合负压封闭引流（Vacuum sealing drainage,VSD）对深Ⅱ度烧伤创面愈合后瘢痕挛缩 畸形的影响。方法：选取2018年6月-2021年3月收治的120例深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形患者为研究对象，采用 随机数字表法分为观察组60例和对照组60例。对照组采用常规方法并VSD治疗，观察组在对照组治疗基础上联合外用活性 因子敷料，两组均持续治疗14 d。治疗结束后，评估两组治疗效果，采用酶联免疫法检测血清白介素-10（Interleukin6,IL-10）和细胞间黏附分子（Intercellular adhesion molecule 1,ICAM-1）水平，采用放射免疫法检测血清表皮生长 因子（Epidermalgrowth factor,EGF）水平；比较两组治疗后1、3、6个月的瘢痕厚度。采用温哥华瘢痕量表（Vancouver scar scale,VSS）评估两组治疗前及治疗1、3、6个月烧伤部位瘢痕修复情况。结果：观察组治疗有效率为91.67%，高于对照 组的78.33%（P＜0.05）；观察组患者治疗后1、3、6个月的瘢痕厚度均低于对照组（P＜0.05）；治疗后，观察组IL-10和EGF水平高 于对照组，ICAM-1低于对照组，差异均有统计学意义（P＜0.05）；治疗后1、3、6个月，观察组VSS评分均低于对照组（P＜0.05）。 结论：活性因子敷料结合VSD可提高深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形疗效和瘢痕瘢痕挛缩畸形改善效果，安全性高。
Abstract:
Objective To explore the effects of active factor dressing combined with wound vacuum sealing drainage (VSD) on scar contracture deformity after wound healing in deep degree-II burn. Methods A total of 120 patients with scar contracture deformity after wound healing and deep degree-Ⅱ burn admitted to the hospital were enrolled as the research objects between June 2018 and March 2021.According to random number table method,they were divided into observation group (60 cases) and control group (60 cases).The control group was given routine treatment and VSD,while observation group was given active factor dressings on basis of control group.All were continuously treated for 14 d.After treatment,curative effect in both groups was evaluated.The levels of serum interleukin-10 (IL-10) and intercellular adhesion molecule 1 (ICAM-1) were detected by enzyme-linked immunosorbent assay.The level of serum epidermal growth factor (EGF) was detected by radioimmunoassay. At1,3 and 6 months after treatment,scar thickness was compared between the two groups. All were followed up for 6 months after treatment. The scar repair at burn sites in both groups was evaluated by Vancouver Scar Scale (VSS) before treatment,at 1,3 and 6 months after treatment. Results The response rate of treatment in observation group was higher than that in control group (91.67% vs 78.33%) (P ＜0.05).At 1 month,3 months and 6 months after treatment,scar thickness in observation group was thinner than that in control group (P ＜0.05). After treatment,levels of IL-10 and EGF in observation group were higher than those in control group,while ICAM-1 was lower than that in control group (P ＜0.05).At 1 month,3 months and 6 months after treatment, VSS score in observation group was lower than that in control group (P＜0.05). Conclusion Active factor dressing combined with VSD can improve curative eff ect and improvement effect of scar contracture deformity after wound healing in deep degree- Ⅱ burn,with high safety.

相似文献/References:

[1]黄祖根,吴杉英,雷 忱. 清创术联合负压封闭引流技术治疗糖尿病足创面的临床观察[J].中国美容医学,2018,(12):36.
　HUANG Zu-gen,WU Shan-ying,LEI Chen. Observation of Debridement Combined with Vacuum Sealing Drainage in Treating Diabetic Foot Wounds[J].Medical Aesthetics and Beauty,2018,(3):36.
[2]白燕玲,冯艳玲,邓小芬. 结构化管理模式在小腿皮肤软组织撕脱伤VSD干预中的应用[J].中国美容医学,2019,(05):154.
　BAI Yan-ling,FENG Yan-ling,DENG Xiao-fen. Application of Structured Management Model in VSD Intervention for Skin and Soft Tissue Avulsion Injury of Leg[J].Medical Aesthetics and Beauty,2019,(3):154.
[3] 米增法. 下腹部带蒂超薄皮瓣修复术联合负压封闭引流治疗手部热压伤[J].中国美容医学,2020,(9):74.
　 MI Zeng-fa. Observation on the Curative Effect of Pedicled Ultra-thin Flap Repair of the LowerAbdomen Combined with Vacumm Sealing Drainage Technique in the Treatment ofHot Pressure Injury of Hand[J].Medical Aesthetics and Beauty,2020,(3):74.
[4] 梁 云,张国安. 亲水性纤维含银敷料联合负压封闭引流对深Ⅱ度烧伤创面愈合及VEGF的影响[J].中国美容医学,2020,(11):38.
　 LIANG Yun,ZHANG Guo-an. Effect of Hydrophilic Fiber Silver Dressing Combined with Vacuum Sealing Drainageon Wound Healing and VEGF in Patients with Deep Second Degree Burn[J].Medical Aesthetics and Beauty,2020,(3):38.
[5] 王洁瑜,杨 阳,陆兰云. 综合护理干预在负压封闭引流治疗撕裂伤创面中的应用[J].中国美容医学,2021,(2):163.
　 WANG Jie-yu,YANG Yang,LU Lan-yun. Application of Comprehensive Nursing Intervention in the Treatment of LaceratedWound with Vacuum Sealing Drainage[J].Medical Aesthetics and Beauty,2021,(3):163.
[6] 李 晴,于文君,刘鹏程,等. 自体皮肤回植联合负压封闭引流修复皮肤撕脱伤的疗效及影响因素分析[J].中国美容医学,2021,(9):41.
　 LI Qing,YU Wen-jun,LIU Peng-cheng,et al. Analysis of Curative Effect and Influencing Factors of Autologous Skin ReplantationCombined with Vacuum Sealing Drainage to Repair Skin Avulsion Injury[J].Medical Aesthetics and Beauty,2021,(3):41.
[7]徐 敏,郭忠梁,罗长生.局部氧疗联合负压封闭引流治疗皮肤深Ⅱ度损伤的疗效探讨[J].中国美容医学,2022,(5):53.
　XU Min,GUO Zhongliang,LUO Changsheng.Effect of Topical Oxygen Therapy Combined with Vacuum Sealing Drainage in the Treatment of Deep Second-degree Skin Injury[J].Medical Aesthetics and Beauty,2022,(3):53.
[8]颉黄峰,陈 骅,戴如冰,等.削痂植皮术联合负压封闭引流治疗中度烧伤创面的临床效果观察[J].中国美容医学,2022,(6):70.
　JIE Huangfeng,CHEN Hua,DAI Rubing,et al.Clinical Effects of Tangential Excision and Skin Grafting Combined with Vacuum Sealing Drainage in the Treatment of Moderate Burn Wounds[J].Medical Aesthetics and Beauty,2022,(3):70.
[9]李明霞.VAC联合植皮修复儿童下肢大面积皮肤缺损[J].中国美容医学,2022,(6):74.
　LI Mingxia.Clinical Effect of VAC Combined with Skin Grafting in Repairing Large Skin Defects of Lower Limbs in Children[J].Medical Aesthetics and Beauty,2022,(3):74.
[10]孙 诚,张茂红,孙丰华.人工真皮联合VSD及自体刃厚皮片移植治疗烧伤后瘢痕增生的疗效及影响因素分析[J].中国美容医学,2022,(8):52.
　SUN Cheng,ZHANG Maohong,SUN Fenghua.Effect and Influencing Factors of Artificial Dermis Combined with VSD and Autologous Blade Thickness Skin Grafting in the Treatment of Scar Hyperplasia after Burn[J].Medical Aesthetics and Beauty,2022,(3):52.

更新日期/Last Update: 2023-04-04