[1]赵光耀,章祥洲,吴军军.优化脉冲光、点阵CO2激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕[J].中国美容医学,2023,(8):58-62.[doi:10.15909/j.cnki.cn61-1347/r.005834]
　ZHAO Guangyao,ZHANG Xiangzhou,WU Junjun.Optimized Pulsed Technology with Fractional CO2 Laser Combined and Compound Heparin Sodium and Allantoin Gel Transdermal Delivery in the Treatment of Hypertrophic Scar After Burns in Children[J].Medical Aesthetics and Beauty,2023,(8):58-62.[doi:10.15909/j.cnki.cn61-1347/r.005834]
点击复制

优化脉冲光、点阵CO2激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年8期
页码:
58-62
栏目:
出版日期:
2023-08-10

文章信息/Info

Title:
Optimized Pulsed Technology with Fractional CO2 Laser Combined and Compound Heparin Sodium and Allantoin Gel Transdermal Delivery in the Treatment of Hypertrophic Scar After Burns in Children
文章编号:
1008-6455(2023)08-0058-04
作者:
赵光耀1 ; 章祥洲2 ; 吴军军2
(1.中国人民解放军联勤保障部队第901医院显微骨科 安徽 合肥 230031 ;2.蚌埠医学院附属蚌埠市第三人民医院烧伤整形 科 安徽 蚌埠 233099 )
Author(s):
ZHAO Guangyao1 ; ZHANG Xiangzhou2 ; WU Junjun2
(1.Department of Microscopic Orthopedics,the 901 Hospital of the PLA Joint Logistic Support Force,Hefei 230031,Anhui,China; 2.Department of Burn and Plastic Surgery,the Third People’s Hospital of Bengbu Affi liated with Bengbu Medical College,Bengbu 233099,Anhui,China)
关键词:
增生性瘢痕; 点阵CO2激光; 优化脉冲光; 复方肝素钠尿囊素凝胶; 临床疗效
Keywords:
hypertrophic scar;  fractional CO2 laser;  optimized pulsed technology;  compound heparin sodium and allantoin gel;  clinical effi cacy
分类号:
R622
DOI:
10.15909/j.cnki.cn61-1347/r.005834
文献标志码:
A
摘要:
目的：探索优化脉冲光、点阵CO2激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕的临床疗效。 方法：选择2020年1月-2021年6月在蚌埠市第三人民医院接受治疗的50例烧伤后增生性瘢痕患儿，按随机数字表法分为试 验组（n =25）和对照组（n =25）。对照组采取优化脉冲光与点阵CO2激光治疗，试验组采用优化脉冲光、点阵CO2激光联 合复方肝素钠尿囊素凝胶透皮给药治疗。两组各治疗3次，每次治疗间隔2个月，在治疗的不同阶段比较温哥华瘢痕量表 （Vancouver scar scale，VSS）评分变化，不良反应发生率及患者满意度。结果：随治疗时间推移，所有患者VSS评分呈逐 渐下降趋势。第3次治疗前及第3次治疗后3个月，试验组VSS评分均低于对照组（P＜0.05）；试验组不良反应发生率及患者 满意度与对照组比较，差异均无统计学意义（P＞0.05）。结论：优化脉冲光、点阵CO2激光联合复方肝素钠尿囊素凝胶透皮 给药治疗儿童烧伤后增生性瘢痕疗效确切，不良反应发生率较低，患者满意度较高。
Abstract:
Objective To explore the clinical efficacy of optimized pulsed technology with fractional CO2 laser combined compound heparin sodium and allantoin gel transdermal delivery in the treatment of hypertrophic scar after burns in children. Methods 50 cases of children patients with hypertrophic scar after burns in Bengbu Third People’s Hospital,between January 2020 and June 2021were selected and divided into experimental group (n=25) and control group (n=25) according to the random number table method.The control group was given optimized pulsed technology combined with fractional CO2 laser,and the test group was treated with the combination of optimized pulsed technology ,fractional CO2 laser and compound heparin sodium and allantoin gel transdermal delivery.The two groups were treated 3 times each,and the interval of each treatment was 2 months.The changes of vancouver scar scale(VSS) were compared at diff erent stages of treatment,incidence of adverse reactions and patients satisfaction were compared between the two groups. Results The VSS scores of all patients showed a gradual downward trend with the treatment time. Before the third treatment and 3 months after the third treatment, the VSS scores of the experimental group were lower than those of the control group (P ＜0.05). There was no signifi cant diff erence in the incidence of adverse reactions and patient satisfaction between the experimental group and the control group (P ＞0.05). Conclusion The effi cacy of optimized pulsed technology with fractional CO2 laser combined compound heparin sodium and allantoin gel transdermal delivery in the treatment of hypertrophic scar after burns in children is defi nite.The treatment can achieve a lower incidence of adverse reactions and a higher patients satisfaction.

相似文献/References:

[1]陈 方. 咪喹莫特调节Th1、Th2细胞相关趋化因子对兔耳增生性瘢痕创面愈合和瘢痕增生的影响[J].中国美容医学,2018,(03):100.
　CHEN Fang. Effect of Imiquimod Regulating Th1 and Th2 Cell-associated Chemokines on Wound Healing and Scar Proliferation in Rabbits[J].Medical Aesthetics and Beauty,2018,(8):100.
[2]黄显翔,张 伟,叶光荣,等. CO2点阵激光治疗增生性瘢痕的临床疗效及对TGF-β1表达的影响[J].中国美容医学,2018,(08):108.
　HUANG Xian-xiang,ZHANG Wei,YE Guang-rong,et al.Analysis of the Clinical Effects and Influence on Expression of TGF-β1 of CO2 Lattice Laser in the Treatment of Hypertrophic Scar[J].Medical Aesthetics and Beauty,2018,(8):108.
[3]谢 彬. 深度烧伤患者弹力绷带压力治疗对增生性瘢痕恢复情况的影响[J].中国美容医学,2018,(10):62.
　XIE Bin. Effect of Pressure Treatment with Elastic Bandage on Recovery of Hypertrophic Scar in Patients with Deep Burn[J].Medical Aesthetics and Beauty,2018,(8):62.
[4]俞 舜. 微等离子体射频联合曲安奈德超声导入治疗增生性瘢痕疗效分析[J].中国美容医学,2019,(02):63.
　YU Shun. Clinical Study on Microplasma Radiofrequency Combined with Ultrasonic ImportingTriamcinolone Acetonide in the Treatment of Hypertrophic Scar[J].Medical Aesthetics and Beauty,2019,(8):63.
[5]史 敏,李 娜,郭晓波,等.miR-21调控PTEN/PI3K/Akt通路抑制增生性瘢痕形成的机制研究[J].中国美容医学,2019,(03):92.
　SHI Min,LI Na,GUO Xiao-bo,et al. Mechanism of miR-21 Inhibiting Human Hypertrophic Scar Formation by RegulatingPTEN/PI3K/Akt Pathway[J].Medical Aesthetics and Beauty,2019,(8):92.
[6]李 丽,王 林. 正常皮肤与病理性瘢痕组织中HIF-1α和促炎细胞因子水平比较及两者相关性研究[J].中国美容医学,2019,(04):71.
　LI Li,WANG Lin. Levels of HIF-1α and Proinflammatory Cytokines in Normal Skin and PathologicalScar Tissue and Their Correlation[J].Medical Aesthetics and Beauty,2019,(8):71.
[7]史 敏 李 娜 陈 雷 刘兆旺 魏超鹏综述,封兴华审校. 自噬、miRNA与增生性瘢痕的研究进展[J].中国美容医学,2019,(04):160.
　SHI Min,LI Na,CHEN Lei,et al. Advance in Research on Autophagy, miRNA and Hypertrophic Scar[J].Medical Aesthetics and Beauty,2019,(8):160.
[8]吴志贤,李 响,莫自增,等. 异泽兰黄素通过PDGFβ/ERK信号通路抑制增生性瘢痕生长的机制探讨[J].中国美容医学,2019,(07):44.
　WU Zhi-xian,LI Xiang,MO Zi-zeng,et al.Eupatilin Inhibits Hypertrophic Scar Proliferation Via the PDGFβ/ERK Signaling Pathway[J].Medical Aesthetics and Beauty,2019,(8):44.
[9]伍星蓉,周平华,吴志强,等. 皮损内注射曲安奈德联合CO2点阵激光治疗增生性瘢痕[J].中国美容医学,2019,(09):32.
　WU Xing-rong,ZHOU Ping-hua,WU Zhi-qiang,et al. Intradermic Injection Triamcinolone Acetonide Combined with CO2 Dot Array Laserin the Treatment of Hypertrophic Scar[J].Medical Aesthetics and Beauty,2019,(8):32.
[10]李山林,陈小君,杨海微,等. 曲安奈德辅助激光治疗增生性瘢痕的疗效及对TGF-β1的影响[J].中国美容医学,2019,(12):66.
　LI Shan-lin,CHEN Xiao-jun,YANG Hai-wei,et al. Therapeutic Effect and the Effect of TGF-β1 of Patients with Hypertrophic Scar UsingTriamcinolone Acetonide-assisted Laser Therapy[J].Medical Aesthetics and Beauty,2019,(8):66.

更新日期/Last Update: 2023-08-30