[1]王莉文,方 静,王 静,等.1 565 nm非剥脱点阵激光联合A型肉毒毒素注射治疗眶周皱纹疗效分析[J].中国美容医学,2024,(9):87-91.
　WANG Liwen,FANG Jing,WANG Jing,et al.Efficacy of 1 565 nm Non-ablative Fractional Laser Combined with Type A Botulinum Toxin Injection in Periorbital Wrinkles[J].Medical Aesthetics and Beauty,2024,(9):87-91.
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1 565 nm非剥脱点阵激光联合A型肉毒毒素注射治疗眶周皱纹疗效分析()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年9期
页码:
87-91
栏目:
出版日期:
2024-08-26

文章信息/Info

Title:
Efficacy of 1 565 nm Non-ablative Fractional Laser Combined with Type A Botulinum Toxin Injection in Periorbital Wrinkles
文章编号:
1008-6455（2024）09-0087-04
作者:
王莉文1 ; 方 静1 ; 王 静1 ; 甘智慧1 ; 王 娟1; 2
[ 1.蚌埠医科大学研究生院 安徽 蚌埠 233030 ;2.中国科学技术大学附属第一医院(安徽省立医院)
Author(s):
WANG Liwen1 ;  FANG Jing1 ;  WANG Jing1 ;  GAN Zhihui1 ;  WANG Juan1; 2
( 1. Graduate School of Bengbu Medial College, Bengbu 233030, Anhui, China; 2. Department of Dermatology, the First Affi liated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China )
关键词:
非剥脱点阵激光; A型肉毒毒素; 眶周皱纹; VISIA面部检测
Keywords:
non-ablative fractional laser;  type A botulinum toxin;  periorbital wrinkles;  VISIA facial detection
分类号:
R730.57
文献标志码:
A
摘要:
目的：探究1 565 nm非剥脱点阵激光联合A型肉毒毒素注射治疗眶周皱纹的疗效。方法：纳入2022年10月-2023年8 月笔者科室诊治的108例眶周皱纹就医者为研究对象，按照随机数表法分为肉毒毒素组（A型肉毒毒素注射组）、激光组 （1 565 nm非剥脱点阵激光治疗组）和联合治疗组（1 565 nm非剥脱点阵激光联合A型肉毒毒素注射组），每组就医者均为36 例。在治疗后第4周、12周、24周时随访三组就医者，采用VISIA皮肤分析仪皱纹评分、Fitzpatrick面部皱纹分级评 分、整体美学改善量表（Global aesthetic improvement scale，GAIS）评分，评价三组就医者治疗效果并记录不良 反应。结果：在治疗后第4、12、24周随访，三组就医者VISIA皱纹评分和Fitzpatrick皱纹评分较治疗前均有不同程度的下降；在治疗后第4周和12周时，联合组及肉毒毒素组VISIA皱纹评分和Fitzpatrick皱纹评分均低于激光组（P＜0.05）， 联合组与肉毒毒素组两组间差异无统计学意义（P＞0.05）；在治疗后第24周时，肉毒毒素组就医者眶周VISIA皱纹评分和 Fitzpatrick 皱纹评分上升，均为联合组＜激光组＜肉毒毒素组（P＜0.05）。联合组在治疗后4周、12周、24周时GAIS评分 总有效率均高于激光组和肉毒毒素组（P＜0.05）。结论：1 565 nm非剥脱点阵激光联合A型肉毒毒素治疗改善眶周疗效显著 持久，安全性好，美学效果更佳。
Abstract:
Objective To investigate the effi cacy of 1 565 nm non-ablative fractional laser combined with type A botulinum toxin injection in the treatment of periorbital wrinkles. Methods A total of 108 patients with periorbital wrinkles treated in the author’s department from October 2022 to August 2023 were enrolled in this study. They were randomly divided into three groups: the botulinum toxin group (type A botulinum toxin injection group), the laser group (1 565 nm non-ablative fractional laser treatment group), and the combination therapy group (1 565 nm non-ablative fractional laser combined with type A botulinum toxin injection group), with 36 patients in each group. The patients were followed up at 4 weeks, 12 weeks, and 24 weeks after treatment. Wrinkle scores were evaluated using the VISIA skin analysis system, Fitzpatrick facial wrinkle grading scale, and the Global Aesthetic Improvement Scale (GAIS) to assess the treatment eff ects of the three groups and record adverse reactions. Results At the 4th, 12th, and 24th weeks after the initial treatment, the VISIA scores and Fitzpatrick scores of the three groups showed varying degrees of improvement compared to before treatment. At the 4th and 12th weeks after the initial treatment, the VISIA scores and Fitzpatrick scores in the combination therapy group and the botulinum toxin group were lower than those in the laser group (P ＜0.05), with no significant statistical difference between the two groups(P＞0.05). However, at the 24th week after the initial treatment, the periorbital wrinkle scores of the botulinum toxin group increased, with the VISIA scores and Fitzpatrick scores in the order of combination therapy group ＜ laser group ＜ botulinum toxin group (P ＜0.05). The combination therapy group had a signifi cantly higher total eff ective rate of GAIS scores than the laser group and the botulinum toxin group at 4 weeks, 12 weeks, and 24 weeks after the initial treatment (P ＜0.05). Conclusion 1 565 nm non-ablative fractional laser combined with Type A botulinum toxin treatment signifi cantly improves periorbital therapy outcomes, demonstrating excellent safety and enhanced aesthetic results.

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更新日期/Last Update: 2024-08-28