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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2019年03期

页码:

76-79

栏目:

出版日期:

2019-03-11

文章信息/Info

Title:

 Short-term and Long-term Effects of Triamcinolone Acetonide, Dot Laser and Cream
in the Treatment of Scar Hyperplasia

文章编号:

1008-6455(2019)03-0076-04

作者:

刘 艳¹; 马晓蕾²

Author(s):

LIU Yan1;  MA Xiao-lei2

关键词:

[关键词]增生性瘢痕; 乳膏; 点阵激光; 曲安奈德; 序贯治疗

Keywords:

Key words: hypertrophic scar;  cream;  fractional laser;  triamcinolone acetonide;  sequential therapy

分类号:

R619+.6

文献标志码:

A

摘要:

[摘要]目的：探讨曲安奈德联合点阵激光及乳膏外涂序贯治疗增生性瘢痕近远期的治疗效果。方法：选取笔者医院2014年5
月-2017年5月收治的90例增生性瘢痕患者，根据随机数字表法分成A组、B组、C组，每组30例。A组：采用曲安奈德序贯点阵
激光治疗；B组：采用点阵激光联合乳膏外涂治疗；C组：采用曲安奈德联合点阵激光及乳膏外涂序贯治疗。比较三组治疗
后3、6个月的临床疗效，分别在患者治疗前及治疗后3、6个月测定瘢痕体积与血红素、黑色素含量，并取瘢痕组织检测转
录因子63（Protein63，P63）、角蛋白19（Cytokeratin19，CK19）在其中的强阳性表达率。结果：C组治疗后3个月的总有
效率为93.33%，高于A、B组的73.33%，差异有统计学意义（P ＜0.05），A、B、C组治疗后6个月的总有效率分别为93.33%、
96.67%、100.00%，组间比较无统计学意义（P ＞0.05）。三组治疗后3、6个月，瘢痕体积及血红素、黑色素含量均低于治疗
前，且C组治疗后3个月的瘢痕体积、黑色素含量低于A、B组，差异有统计学意义（P ＜0.05）。三组治疗后3、6个月的P63、
CK19强阳性表达率高于治疗前，且C组治疗后3个月两者强阳性表达率高于A、B组，差异有统计学意义（P ＜0.05）。A、B组
患者均未出现不良反应，C组不良反应发生率为6.67%，三组不良反应发生率比较无统计学意义（P ＞0.05）。结论：曲安奈
德联合点阵激光与乳膏外涂序贯治疗能促进增生性瘢痕患者病情的改善，近远期效果均比较理想，不良反应少，安全性高。

Abstract:

Abstract: Objective To investigate the short-term and long-term effects of triamcinolone acetonide, dot laser and cream on
sequential treatment of scar hyperplasia. Methods 90 cases of scar hyperplasia admitted to our hospital from May 2014 to May
2017 were selected and divided into A group, B group and C group according to random number table.30 cases in each group.In
group A, Cu Ann Ned sequential laser therapy was used.In group A, Cu Ann Ned sequential dot matrix laser was used, group B
was treated with dot matrix laser combined with cream, and group C was treated with Cu Ann Ned, dot matrix laser and cream.
The clinical efficacy of three groups was compared between 3 and 6 months after treatment.Scar volume and hemoglobin and
melanin content were measured before and 3 and 6 months after treatment respectively.The scar tissue was used to detect the
strong positive expression rate of Protein63 (P63) and Cytokeratin19 (CK19). Results The total effective rate of group C in 3
months after treatment was 93.33%, higher than 73.33% of group A and B.The difference was statistically significant (P ＜0.05).
The total effective rates in group A, B and C 6 months after treatment were 93.33%, 96.67% and 100%, respectively, and there
was no significant difference between the two groups (P ＞0.05).The volume of scar and hemoglobin and melanin in the three
groups were lower than those before treatment for 3 and 6 months, and the volume of scar and melanin in group C were lower
than that of group A and B after 3 months of treatment (P ＜0.05).The strong positive expression rates of P63 and CK19 in the
three groups were higher than those before treatment in 3 and 6 months after treatment, and the positive expression rate of two
in group C was higher than that in group A and B at 3 months after treatment.The difference was statistically significant (P ＜0.05).
No adverse reactions were found in group A and B. The incidence of adverse reactions in group C was 6.67%, and there was
no significant difference in the incidence of adverse reactions between the three groups (P ＞0.05). Conclusion The sequential
therapy of triamcinolone acetonide,dot matrix laser and cream can promote the improvement of the condition of patients with
hypertrophic scar. In the near and long term, the effect is ideal,less adverse reaction and high safety.

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更新日期/Last Update: 2019-04-01