[1] 潘廷猛,陈雪路,施 雯,等. 羟氯喹联合多西环素序贯光电协同治疗I型及Ⅱ型玫瑰痤疮临床观察[J].中国美容医学,2020,(9):22-26.
　 PAN Ting-meng,CHEN Xue-lu,SHI Wen,et al. Clinical Observation on the Sequential Photoelectric Treatment of Rosacea Type Iand Type II with Hydroxychloroquine and Doxycycline[J].Medical Aesthetics and Beauty,2020,(9):22-26.
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 羟氯喹联合多西环素序贯光电协同治疗I型及Ⅱ型玫瑰痤疮临床观察
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年9期
页码:
22-26
栏目:
出版日期:
2020-09-10

文章信息/Info

Title:
 Clinical Observation on the Sequential Photoelectric Treatment of Rosacea Type I
and Type II with Hydroxychloroquine and Doxycycline
文章编号:
1008-6455(2020)09-0022-05
作者:
 潘廷猛1; 陈雪路1; 施 雯1; 荣光辉2; 何彩凤3
Author(s):
 PAN Ting-meng1;  CHEN Xue-lu1; SHI Wen1; RONG Guang-hui2; HE Cai-feng3
关键词:
 [关键词]玫瑰痤疮; 光电协同; 羟氯喹; 多西环素; 疗效
Keywords:
 Key words:rosacea;  electro-optical synergy; hydroxychloroquine;  doxycycline; efficacy
分类号:
R758.73+4
文献标志码:
A
摘要:
[摘要]目的：观察羟氯喹联合多西环素序贯光电协同技术(Electro-optical synergy，ELOS)治疗I型、Ⅱ型玫瑰痤疮的有效
性及安全性。方法：将78例I型及Ⅱ型玫瑰痤疮患者随机分为对照组和观察组，每组39例。对照组：给予口服羟氯喹200mg，
2次/d；口服多西环素片0.1g，1次/d，共8周；观察组：给予羟氯喹联合多西环素口服8周，方法同对照组，停药后开始ELOS
光电协同治疗，每4周治疗1次，连续治疗4次。治疗结束前、后对患者的皮损及症状评分并记录治疗不良反应。结果：疗程
结束时，观察组治疗有效率为89.74%，显著高于对照组的66.67%，差异有统计学意义（P ＜0.05）。治疗后观察组患者红
斑、毛细血管扩张、丘疹、脓疱4项症状评分均明显低于对照组，差异均有统计学意义（P ＜0.05）。两组患者治疗后瘙痒症
状评分无统计学差异（P ＞0.05）。结论：羟氯喹联合多西环素序贯光电协同治疗I型、Ⅱ型玫瑰痤疮安全有效，尤其对毛细
血管扩张、红斑、丘疹及脓疱效果明显，为治疗I型、Ⅱ型玫瑰痤疮提供了更优化的方案。

Abstract:
Abstract:Objective To observe the efficacy and safety of hydroxychloroquine combined with docycline sequential
photoelectric synergy (ELOS) in the treatment of rosacea type Ⅰ and type Ⅱ. Methods 78 patients with rosacea type Ⅰ and
type Ⅱ were randomly divided into observation group (39 cases) and control group (39 cases). The control group was given
hydroxychloroquine 200mg orally twice a day, doxycycline 0.1g orally once a day for 8 weeks. The observation group was
given hydroxychloroquine and doxycycline orally for 8 weeks. The method was the same as that of the control group. After
stopping the drug, ELOS photoelectric synergistic treatment was started, once every 4 weeks, four times in a row. Before and
after treatment, the patients’ skin lesions and symptoms were scored and adverse reactions were recorded. Results At the end of
the course of treatment, The effective rate of the observation group was 89.74%, which was surely higher than that of the control
group (66.67%). The difference was statistically significant (P ＜0.05). After treatment, the scores of erythema, telangiectasia,
papules and pustules in the observation group were clearly lower than those in the control group, and the difference was
statistically significant (P ＜0.05). While the difference in the symptoms of pruritus between the two groups (P ＞0.05) after their
treatment had no statistical significance. Conclusion Hydroxychloroquine combined with doxycycline sequential photoelectric
treatment is safe and effective for rosacea type Ⅰ and type Ⅱ, especially for telangiectasia, erythema, pimples and pustules,
which provides a more optimized scheme for rosacea typeⅠand type Ⅱ.

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更新日期/Last Update: 2020-09-25