[1] 陆 敏,孙淑娟,李向花. 重组牛碱性成纤维细胞生长因子凝胶对玫瑰痤疮皮肤损伤的修复作用及安全性临床分析[J].中国美容医学,2021,(7):71-74.
　 LU Min,SUN Shu-juan,LI Xiang-hua. Study and Analysis of the Effectiveness and Safety of Recombinant Bovine BasicFibroblast Growth Factor Gel in Repairing Rosacea Skin Damage[J].Medical Aesthetics and Beauty,2021,(7):71-74.
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 重组牛碱性成纤维细胞生长因子凝胶对玫瑰痤疮皮肤损伤的修复作用及安
全性临床分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年7期
页码:
71-74
栏目:
出版日期:
2021-07-10

文章信息/Info

Title:
 Study and Analysis of the Effectiveness and Safety of Recombinant Bovine Basic
Fibroblast Growth Factor Gel in Repairing Rosacea Skin Damage
文章编号:
1008-6455（2021）07-0071-04
作者:
 陆 敏1; 孙淑娟2 ; 李向花3
Author(s):
 LU Min1;  SUN Shu-juan2;  LI Xiang-hua3
关键词:
 [关键词]玫瑰痤疮; 重组牛碱性成纤维细胞生长因子; 临床疗效; 修复作用; 安全性
Keywords:
 Key words: rosacea;  recombinant bovine basic fibroblast growth factor;  clinical efficacy;  repair effect;  security
分类号:
R758.73+4
文献标志码:
A
摘要:
凝胶对玫瑰痤疮皮肤损伤的修复作用及安全性分析。方法：本研究为随机、单盲、安慰剂对照研究，一共纳入了128例玫瑰痤
疮患者，随机分为治疗组（n=65）和对照组（n=63）。两组患者均接受硫酸羟氯喹（HCQ）治疗，0.2克/次，2 次/天。治疗组
在此基础上局部应用rbFGF凝胶治疗（300IU/cm2），8周为1个疗程；对照组采用凝胶载体。分别在治疗前和治疗4周、8周、
停药4周时对红斑、毛细血管扩张、丘疹、脓疱等客观体征及潮红、干燥、灼热、瘙痒等主观症状进行评分，并且测定治疗
前后的经皮水分丢失值、角质层含水量及表皮皮脂含量。结果：治疗组，治疗4周、8周及停药4周时的客观体征和主观症状
评分分别为2.06±0.51,1.35±0.55和1.00±0.45,较对照组的2.43±0.57,2.17±0.53和1.93±0.45明显降低；与对照组相
比，治疗组经治疗后的表皮皮脂含量及皮肤角质层含水量升高，经皮水分丢失降低，差异均有统计学意义（P ＜0.05）；治
疗4周、8周及停药4周时，治疗组患者的总有效率明显高于对照组（分别为56.63%vs.28.84%，85.11% vs.40.81%，96.56%
vs.55.82%），两组均未出现不良反应。结论：rbFGF凝胶对于玫瑰痤疮皮肤损伤的修复有确切的治疗效果，且安全性较高，
值得临床推广。

Abstract:
Abstract: Objective To investigate the repair effect and safety analysis of recombinant bovine basic fibroblast growth factor
(rb-bFGF) gel on rosacea skin damage. Methods This study is a randomized, single-blind, placebo-controlled study. A total
of 128 patients with rosacea were enrolled and randomly divided into treatment group (n =65) and control group (n=63).
Both groups of patients received hydroxychloroquine sulfate (HCQ), 0.2g/time, 2 times/d. On this basis, the treatment group
used topical rbFGF gel treatment (300IU/cm2), 8 weeks as a course of treatment; the control group used gel carrier. Score the
objective signs of erythema, telangiectasia, papules, pustules, and subjective symptoms such as flushing, dryness, burning, and
itching before treatment, 4 weeks, 8 weeks, and 4 weeks after treatment. Transdermal water loss value, stratum corneum water
content, epidermal sebum content. Results The objective signs and subjective symptom scores of the treatment group were
2.06±0.51, 1.35±0.55, and 1.00±0.45 at 4 weeks, 8 weeks of treatment, and 4 weeks of discontinuation, respectively, compared
with 2.43±0.57, 2.17±0.53 and 2.17±0.53 of the control group 1.93±0.45 is significantly reduced. Compared with the control
group, the epidermal sebum content and stratum corneum water content of the treatment group increased after treatment, and the
transdermal water loss decreased, and the difference was statistically significant (P ＜0.05). At 4 weeks, 8 weeks and 4 weeks of
treatment, the total effective rate of patients in the treatment group was significantly higher than that of the control group (56.63%
vs. 28.84%, 85.11% vs.40.81%, 96.56% vs. 55.82%). There were no adverse reactions in the two groups. Conclusion rbFGF
gel has a definite therapeutic effect on the repair of rosacea skin damage, and it is safe and worthy of promotion.

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更新日期/Last Update: 2021-08-03