[1] 韩 炎,王俊华,周丽芝. 牙周基础治疗对2型糖尿病合并慢性牙周炎患者糖脂代谢及炎症反应的影响[J].中国美容医学,2021,(6):136-139.
　 HAN Yan,WANG Jun-hua,ZHOU Li-zhi. Effects of Periodental Non-surgical Treatment on Glycolipid Metabolism andInflammatory Response in Patients with Type 2 Diabetes Mellitus Complicated withChronic Periodontitis[J].Medical Aesthetics and Beauty,2021,(6):136-139.
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 牙周基础治疗对2型糖尿病合并慢性牙周炎患者糖脂代谢及炎症反应的
影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年6期
页码:
136-139
栏目:
出版日期:
2021-06-10

文章信息/Info

Title:
 Effects of Periodental Non-surgical Treatment on Glycolipid Metabolism and
Inflammatory Response in Patients with Type 2 Diabetes Mellitus Complicated with
Chronic Periodontitis
文章编号:
1008-6455(2021)06-0136-03
作者:
 韩 炎1; 王俊华1; 周丽芝2
Author(s):
 HAN Yan1; WANG Jun-hua1; ZHOU Li-zhi2
关键词:
 [关键词]2型糖尿病; 慢性牙周炎; 牙周基础治疗; 糖脂代谢; 炎症反应
Keywords:
 Key words:Type 2 diabetes mellitus;  chronic periodontitis;  periodental non-surgical treatment;  glycolipid metabolism; inflammatory response
分类号:
R781.4+2
文献标志码:
A
摘要:
[摘要]目的：探讨牙周基础治疗对2型糖尿病(Type 2 diabetes mellitus，T2DM)合并慢性牙周炎患者糖脂代谢及炎症反应
的影响。方法：按照随机数字表法将2019年1月-2019年12月笔者医院收治的150例T2DM合并慢性牙周炎患者分为对照组与观
察组，每组75例。对照组患者进行糖尿病常规治疗，观察组患者在糖尿病常规治疗的基础上进行牙周基础治疗，均连续治疗
3个月。比较两组糖代谢指标[空腹血糖(Fasting blood-glucose，FBG)、餐后2h血糖(2h postprandial blood glucose，
2hPG)、糖化血红蛋白(Glycosylated hemoglobin，HbA1c)]，脂代谢指标[总胆固醇(Total cholesterol，TC)、甘油三
酯(Triglyceride，TG)、低密度脂蛋白(Low density lipoprotein，LDL)、高密度脂蛋白(High density lipoprotein，
HDL)]及炎症因子[肿瘤坏死因子-α(Tumor necrosis factor-α，TNF-α)、白细胞介素-1β(Interleukin-1β，
IL-1β)、IL-6、IL-10]的变化。结果：治疗后，观察组的FBG[(5.99±0.40)mmol/L vs(6.87±0.80)mmol/L]、
2hPG[(7.41±0.46)mmol/L vs (8.93±0.90)mmol/L]、HbA1c[(6.45±0.58)%vs(7.84±0.66)%]水平均明显低于对照
组(P ＜0.05)；观察组的TG[(0.98±0.22)mmol/L vs(2.20±0.79)mmol/L]水平明显低于对照组(P ＜0.05)；观察组的
TNF-α[(1.15±0.32)pg/ml vs(2.87±0.65)pg/ml]、IL-1β[(0.40±0.15)pg/ml vs(3.71±0.94)pg/ml]水平明显低于对
照组(P ＜0.05)，IL-10[(11.25±1.44)pg/ml vs(7.82±1.90)pg/ml]水平明显高于对照组(P ＜0.05)。 结论：牙周基础治疗
对T2DM合并慢性牙周炎患者的糖脂代谢及炎症反应具有明显的改善作用。

Abstract:
Abstract:Objective To discuss the effects of periodental non-surgical treatment on glycolipid metabolism and inflammatory
response in patients with type 2 diabetes mellitus(T2DM) complicated with chronic periodontitis. Methods According to
the random number method, 150 patients with T2DM complicated with chronic periodontitis who were divided into control
group and observation group in our hospital from January to December 2019, with 75 cases in each group. All patients were
treated continuously for 3 months.The glucose metabolism indicators[fasting blood glucose (FBG), 2 h postprandial blood
glucose(2 HPG), glycosylated hemoglobin(HbA1c)],lipid metabolism indicators[total cholesterol(TC), triglyceride(TG),
low density lipoprotein (LDL), high density lipoprotein (HDL)] and inflammatory factors[tumor necrosis factor-α(TNF-α),
interleukin-1β(IL-1β), IL-6, IL-10]. Results After treatment,the level of FBG[(5.99±0.40)mmol/L vs (6.87±0.80)mmol/
L], 2hPG[(7.41±0.46)mmol/L vs (8.93±0.90)mmol/L], HbA1c[(6.45±0.58)% vs (7.84±0.66)%] in observation group was
significantly lower than that in control group(P <0.05). The level of TG[(0.98±0.22)mmol/L vs (2.20±0.79)mmol/L] in
observation group was significantly lower than that in control group(P ＜0.05). The level of TNF-α[(1.15±0.32)pg/ml vs
(2.87±0.65)pg/ml], IL-1β[(0.40±0.15)pg/ml vs (3.71±0.94)pg/ml] in observation group was significantly lower than that in
control group and the level of IL-10[(11.25±1.44)pg/ml vs (7.82±1.90)pg/ml] in observation group was significantly higher
than that in control group(P ＜0.05). Conclusion Periodental non-surgical treatment could significantly improve the glycolipid
metabolism and inflammatory response in patients with glycolipid metabolism and inflammatory response in patients with
T2DM complicated with chronic periodontitis.

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更新日期/Last Update: 2021-07-13