[1]孙 恒,倪志福,屈振繁.两种给药方式治疗婴幼儿血管瘤疗效对比研究[J].中国美容医学,2021,(12):86-89.
　SUN Heng,NI Zhi-fu,QU Zhen-fan.Clinical Comparative Study of Two Drug Administration Methods for Treatment of Infantile Hemangiomas[J].Medical Aesthetics and Beauty,2021,(12):86-89.
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两种给药方式治疗婴幼儿血管瘤疗效对比研究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年12期
页码:
86-89
栏目:
出版日期:
2021-12-10

文章信息/Info

Title:
Clinical Comparative Study of Two Drug Administration Methods for Treatment of Infantile Hemangiomas
文章编号:
1008-6455（2021）12-0086-04
作者:
孙 恒; 倪志福; 屈振繁
［湖北医药学院附属太和医院 (十堰市太和医院)
Author(s):
SUN Heng; NI Zhi-fu; QU Zhen-fan
[Department of Pediatric Surgery,Taihe Hospital Affiliated to Hubei University of Medicine( Shiyan Taihe Hospital), Shiyan 442000,Hubei,China]
关键词:
婴幼儿血管瘤; 普萘洛尔; 马来酸噻吗洛尔; 口服; 局部治疗
Keywords:
infantile hemangioma;  propranolol;  timolol maleate;  oral administration; topical therapy;  curative effect
分类号:
R732.2
文献标志码:
A
摘要:
目的：对比口服普萘洛尔同时联合局部涂抹0.5%马来酸噻吗洛尔滴眼液与单纯口服普萘洛尔治疗婴幼儿血管瘤的效果。方法：选择2016年9月-2018年10月笔者医院收治的符合纳入标准的增生期婴幼儿血管瘤144例，通过随机数字表法分成A、B两组，A组仅口服普萘洛尔,共70例；B组口服普萘洛尔并局部涂抹0.5%马来酸噻吗洛尔滴眼液,共74例。治疗持续时间均6个月，比较两组的治疗效果、不良反应的差异及治愈停药3个月后复发率。结果：A组有效率为85.7%，不良反应发生率为12.9%，停药3个月复发率为12.9%；B组有效率为86.5%，不良反应发生率为10.8%，停药3个月复发率为9.5%。两组有效率比较，差异无统计学意义（χ2＝0.018，P＞0.05）；不良反应发生率比较，差异无统计学意义（χ2＝0.145，P＞0.05）；停药3个月复发率比较，差异无统计学意义（χ2＝0.420，P＞0.05）。结论：口服普萘洛尔治疗婴幼儿血管瘤联合局部外用0.5%马来酸噻吗洛尔滴眼液并不会提高近期疗效。
Abstract:
Objective To compare the effect of oral propranolol combined with topical application of 0.5% timolol maleate eye drops and oral propranolol alone in the treatment of infantile hemangioma(IH) and provide reference basis for clinical treatment. Methods A total of 144 cases of proliferative IH admitted from September 2016 to October 2018 . The patients were assigned two groups, according to randomized and controlled principle. The group A (n=70), oral propranolol alone, the group B (n=74), oral propranolol and topical application of 0.5% timolol maleate eye drops. The duration of treatment was 6 months. The differences in efficacy, adverse reactions between the two groups were compared and the recurrence rate after 3 months of drug withdrawal. Results The effective rate of group A was 85.7% , the incidence of adverse reactions was 12.9% , the recurrence rate after 3 months of drug withdrawal was 12.9% . The effective rate of group B was 86.5%, the incidence of adverse reactions was 10.8% , the recurrence rate after 3 months of drug withdrawal was 9.5% . There was no significant difference in effective rate between the two groups( χ2=0.018, P＞0.05). There was no statistically significant difference in the incidence of adverse reactions(χ2=0.145, P＞0.05). There was no significant difference in the recurrence rate after 3 months of drug withdrawal (χ2=0.420, P＞0.05). Conclusion Oral propranolol combined with topical application of 0.5% timolol maleate eye drops in the treatment of IH did not improve the short-term efficacy.

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更新日期/Last Update: 2022-01-18